Olivier Bouillanne1, Nathalie Neveux2, Ioannis Nicolis3, Emmanuel Curis3, Luc Cynober2, Christian Aussel4. 1. Service de Gérontologie 2, Hôpital Émile-Roux, AP-HP, Limeil-Brévannes, France; Laboratoire de Biologie de la Nutrition, Université Paris Descartes, Paris, France. Electronic address: Olivier.bouillanne@erx.aphp.fr. 2. Laboratoire de Biologie de la Nutrition, Université Paris Descartes, Paris, France; Service Interhospitalier de Biochimie, AP-HP, Hôpitaux Cochin et Hôtel-Dieu, Paris, France. 3. Laboratoire de Biomathématiques, Université Paris Descartes, Faculté de Pharmacie, Paris, France. 4. Laboratoire de Biologie de la Nutrition, Université Paris Descartes, Paris, France; Unité de Nutrition, PUI, AP-HP, Hôpital Henri-Mondor, Créteil, France.
Abstract
OBJECTIVE: Aging is associated with a blunted anabolic response to dietary intake, possibly related to a decrease in systemically available amino acids (AAs), which in turn may stem from increased splanchnic AA metabolism. Splanchnic sequestration can be saturated by pulse feeding (80% of daily protein intake in a single meal), enabling increased protein synthesis. The aim of this study was to explore whether protein pulse feeding increased postprandial AA concentrations, and if so whether this increase persisted after 6 wk of dietary treatment. METHODS: This prospective randomized study enrolled 66 elderly malnourished or at-risk patients in an inpatient rehabilitation unit. All were given a controlled diet for 6 wk. In a spread diet (SD) group (n = 36), dietary protein was spread over the four daily meals. In a pulse diet (PD) group (n = 30), 72% of dietary protein (averaging 1.31 g/kg body weight daily) was consumed in one meal at noon. The patients were evaluated on day 1 and at 6 wk for plasma postprandial (five times from 0 to +180 min) AA concentrations (expressed as area under the curve above baseline). RESULTS:Protein pulse feeding was more efficient than protein spread feeding at increasing plasma postprandial AA concentrations, notably of essential AAs. This increased postprandial AA bioavailability was maintained after 6 wk. CONCLUSIONS: This study demonstrates that increased postprandial AA bioavailability induced by protein pulse feeding persists after 6 wk (i.e., that there is no metabolic adaptation blunting AA bioavailability).
RCT Entities:
OBJECTIVE: Aging is associated with a blunted anabolic response to dietary intake, possibly related to a decrease in systemically available amino acids (AAs), which in turn may stem from increased splanchnic AA metabolism. Splanchnic sequestration can be saturated by pulse feeding (80% of daily protein intake in a single meal), enabling increased protein synthesis. The aim of this study was to explore whether protein pulse feeding increased postprandial AA concentrations, and if so whether this increase persisted after 6 wk of dietary treatment. METHODS: This prospective randomized study enrolled 66 elderly malnourished or at-risk patients in an inpatient rehabilitation unit. All were given a controlled diet for 6 wk. In a spread diet (SD) group (n = 36), dietary protein was spread over the four daily meals. In a pulse diet (PD) group (n = 30), 72% of dietary protein (averaging 1.31 g/kg body weight daily) was consumed in one meal at noon. The patients were evaluated on day 1 and at 6 wk for plasma postprandial (five times from 0 to +180 min) AA concentrations (expressed as area under the curve above baseline). RESULTS: Protein pulse feeding was more efficient than protein spread feeding at increasing plasma postprandial AA concentrations, notably of essential AAs. This increased postprandial AA bioavailability was maintained after 6 wk. CONCLUSIONS: This study demonstrates that increased postprandial AA bioavailability induced by protein pulse feeding persists after 6 wk (i.e., that there is no metabolic adaptation blunting AA bioavailability).
Authors: Daniel R Crabtree; Adrian Holliday; William Buosi; Claire L Fyfe; Graham W Horgan; Alexandra M Johnstone Journal: Geriatrics (Basel) Date: 2022-01-30
Authors: Marta Lonnie; Emma Hooker; Jeffrey M Brunstrom; Bernard M Corfe; Mark A Green; Anthony W Watson; Elizabeth A Williams; Emma J Stevenson; Simon Penson; Alexandra M Johnstone Journal: Nutrients Date: 2018-03-16 Impact factor: 5.717