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Literature DB >> 24348523

The perinucleolar compartment associates with malignancy.

Abstract

The perinucleolar compartment (PNC) is a unique nuclear substructure, forming predominantly in cancer cells both in vitro and in vivo. PNC prevalence (percentage of cells containing at least one PNC) has been found to positively correlate with disease progression in several cancers (breast, ovarian, and colon). While there is a clear association between PNCs and cancer, the molecular function of the PNC remains unclear. Here we summarize the current understanding of the association of PNCs with cancer and its possible functions in cancer cells.

Entities: CellLine Chemical Disease Gene Species

Keywords: PNC; cancer; gene expression regulation; nuclear substructure; structure and function

Year: 2013 PMID： 24348523 PMCID： PMC3862354 DOI： 10.1007/s11515-013-1265-z

Source DB: PubMed Journal: Front Biol (Beijing) ISSN： 1674-7984

65 in total

Review 1. Turning on a fuel switch of cancer: hnRNP proteins regulate alternative splicing of pyruvate kinase mRNA.

Authors: Mo Chen; Jian Zhang; James L Manley
Journal: Cancer Res Date: 2010-10-26 Impact factor: 12.701

Review 2. Of proteins and RNA: the RNase P/MRP family.

Authors: Olga Esakova; Andrey S Krasilnikov
Journal: RNA Date: 2010-07-13 Impact factor: 4.942

3. hnRNP I, the polypyrimidine tract-binding protein: distinct nuclear localization and association with hnRNAs.

Authors: A Ghetti; S Piñol-Roma; W M Michael; C Morandi; G Dreyfuss
Journal: Nucleic Acids Res Date: 1992-07-25 Impact factor: 16.971

4. Mutation of PTB binding sites causes misregulation of alternative 3' splice site selection in vivo.

Authors: I Pérez; C H Lin; J G McAfee; J G Patton
Journal: RNA Date: 1997-07 Impact factor: 4.942

5. Aberrant regulation of insulin receptor alternative splicing is associated with insulin resistance in myotonic dystrophy.

Authors: R S Savkur; A V Philips; T A Cooper
Journal: Nat Genet Date: 2001-09 Impact factor: 38.330

6. A 62,000 molecular weight spliceosome protein crosslinks to the intron polypyrimidine tract.

Authors: J Wang; T Pederson
Journal: Nucleic Acids Res Date: 1990-10-25 Impact factor: 16.971

7. Methoxyethylamino-numonafide is an efficacious and minimally toxic amonafide derivative in murine models of human cancer.

Authors: Yanning Liu; John T Norton; Mark A Witschi; Qun Xu; Guohua Lou; Chen Wang; Daniel H Appella; Zhi Chen; Sui Huang
Journal: Neoplasia Date: 2011-05 Impact factor: 5.715

8. Differentiation-induced colocalization of the KH-type splicing regulatory protein with polypyrimidine tract binding protein and the c-src pre-mRNA.

Authors: Megan P Hall; Sui Huang; Douglas L Black
Journal: Mol Biol Cell Date: 2003-12-02 Impact factor: 4.138

Review 4. Nucleolus and chromatin.

Authors: Christian Schöfer; Klara Weipoltshammer
Journal: Histochem Cell Biol Date: 2018-07-25 Impact factor: 4.304

4 in total

The perinucleolar compartment associates with malignancy.

Review 1. Turning on a fuel switch of cancer: hnRNP proteins regulate alternative splicing of pyruvate kinase mRNA.

Review 2. Of proteins and RNA: the RNase P/MRP family.

3. hnRNP I, the polypyrimidine tract-binding protein: distinct nuclear localization and association with hnRNAs.

4. Mutation of PTB binding sites causes misregulation of alternative 3' splice site selection in vivo.

5. Aberrant regulation of insulin receptor alternative splicing is associated with insulin resistance in myotonic dystrophy.

6. A 62,000 molecular weight spliceosome protein crosslinks to the intron polypyrimidine tract.

7. Methoxyethylamino-numonafide is an efficacious and minimally toxic amonafide derivative in murine models of human cancer.

8. Differentiation-induced colocalization of the KH-type splicing regulatory protein with polypyrimidine tract binding protein and the c-src pre-mRNA.

9. Polypyrimidine tract-binding protein positively regulates inclusion of an alternative 3'-terminal exon.

10. The dynamic organization of the perinucleolar compartment in the cell nucleus.

1. Demethylated HSATII DNA and HSATII RNA Foci Sequester PRC1 and MeCP2 into Cancer-Specific Nuclear Bodies.

Review 2. Nucleolus-derived mediators in oncogenic stress response and activation of p53-dependent pathways.

3. A small molecule inhibitor of the perinucleolar compartment, ML246, attenuates growth and spread of ovarian cancer.

Review 4. Nucleolus and chromatin.