| Literature DB >> 24343839 |
Sunil K Mishra1, Shashi Tiwari, Atul Shrivastava, Shishir Srivastava, Goutam K Boudh, Shivendra K Chourasia, Upma Chaturvedi, Snober S Mir, Anil K Saxena, Gitika Bhatia, Vijai Lakshmi.
Abstract
The aim of the present study was to evaluate the antidyslipidemic effect of ethanolic extract of Rheum emodi rhizomes and its constituents in Triton-WR-1339 and high-fat diet (HFD)-induced dyslipidemic rats. In preliminary screening, the ethanolic extract showed significant activity in Triton-treated rats. Bioassay-guided fractionation of the ethanolic extract resulted in the identification of four anthraquinone derivatives, viz. chrysophanol, emodin, chrysophanol 8-O-β-D-glucopyranoside and emodin 8-O-β-D-glucopyranoside as active constituents. All these compounds significantly reduced plasma lipid levels. The most active compound emodin showed significant lipid-lowering activity in the HFD-fed model. In addition, these compounds showed significant antioxidant activity. The effect of emodin on enzymes modulating lipid metabolism confirms and supports the efficiency of emodin as a potent antidyslipidemic agent.Entities:
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Year: 2013 PMID： 24343839 DOI： 10.1007/s11418-013-0810-z
Source DB: PubMed Journal: J Nat Med ISSN： 1340-3443 Impact factor: 2.343