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Literature DB >> 2434324

Alpha 2-macroglobulin gene expression during rat development studied by in situ hybridization.

V Kodelja, M Heisig, W Northemann, P C Heinrich, W Zimmermann.

Abstract

The sites of alpha 2-macroglobulin mRNA synthesis during rat development have been localized by in situ hybridization using a rat alpha 2-macroglobulin cDNA probe. Fetal liver was found to be the major site of alpha 2-macroglobulin mRNA synthesis. In addition, alpha 2-macroglobulin mRNA was detected in brain, spinal cord and eye. Alpha 2-Macroglobulin mRNA was quantitated by use of a sensitive RNAse protection assay. Maximal levels of alpha 2-macroglobulin mRNA were found in fetal livers shortly before birth. A rapid decline of alpha 2-macroglobulin mRNA occurred within 1 day after parturition. A similar time course, although at an approximately 20-fold lower level, was observed for alpha 2-macroglobulin mRNA in livers of pregnant rats. Alpha 2-Macroglobulin mRNA could also be detected in placenta. The levels were comparable to those found in maternal livers.

Entities: Chemical

Mesh：

Substances：

Year: 1986 PMID： 2434324 PMCID： PMC1167305 DOI： 10.1002/j.1460-2075.1986.tb04622.x

Source DB: PubMed Journal: EMBO J ISSN： 0261-4189 Impact factor: 11.598

28 in total

1. Immunochemical identity of "decidualization-associated protein' and alpha 2 acute-phase macroglobulin in the pregnant rate.

Authors: S C Bell
Journal: J Reprod Immunol Date: 1979-10 Impact factor: 4.054

2. Isolation, characterization and radioimmunoassay of rat alpha macrofetoprotein (acute phase A2 macroglobulin).

Authors: D Hudig; S Sell
Journal: Mol Immunol Date: 1979-08 Impact factor: 4.407

Review 3. The phenomenon of the acute phase response.

Authors: I Kushner
Journal: Ann N Y Acad Sci Date: 1982 Impact factor: 5.691

4. Isolation, cloning and sequence analysis of the cDNA for the alpha-subunit of human chorionic gonadotropin.

Authors: J C Fiddes; H M Goodman
Journal: Nature Date: 1979-10-04 Impact factor: 49.962

5. Studies on human pregnancy-associated plasma protein A. Purification by affinity chromatography and structural comparisons with alpha 2-macroglobulin.

Authors: R G Sutcliffe; B M Kukulska-Langlands; J R Coggins; J B Hunter; C H Gore
Journal: Biochem J Date: 1980-12-01 Impact factor: 3.857

Alpha 2-macroglobulin gene expression during rat development studied by in situ hybridization.

1. Immunochemical identity of "decidualization-associated protein' and alpha 2 acute-phase macroglobulin in the pregnant rate.

2. Isolation, characterization and radioimmunoassay of rat alpha macrofetoprotein (acute phase A2 macroglobulin).

Review 3. The phenomenon of the acute phase response.

4. Isolation, cloning and sequence analysis of the cDNA for the alpha-subunit of human chorionic gonadotropin.

5. Studies on human pregnancy-associated plasma protein A. Purification by affinity chromatography and structural comparisons with alpha 2-macroglobulin.

6. Purification and immunological determination of alpha 2-macroglobulin in serum from injured rats.

7. Subunit structure of the rat alpha-macroglobulin proteinase inhibitors.

8. The alpha macroglobulins of rat serum.

9. Ribonuclease inhibitor from human placenta: rapid purification and assay.

10. Cultured human monocytes synthesize and secrete alpha2-macroglobulin.

1. Expression of Panza, an alpha2-macroglobulin, in a restricted dorsal domain of the primitive gut in Xenopus laevis.