Cong-Sheng Li1, Bi-Rong Guo2, Zeng Guo3, Jing Yang4, Hou-Feng Zheng5, Ai-Ling Wang6. 1. Department of Cardiology, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China; Department of Emergency, Third Affiliated Hospital of Anhui Medical University and First People's Hospital of Hefei, Hefei, Anhui 230061, China. 2. Department of Dermatology, Department of Emergency, Third Affiliated Hospital of Anhui Medical University and First People's Hospital of Hefei, Hefei, Anhui 230061, China. 3. Department of Cardiology, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China. 4. Department of Emergency, Third Affiliated Hospital of Anhui Medical University and First People's Hospital of Hefei, Hefei, Anhui 230061, China. 5. Department of Medicine, Human Genetics, Epidemiology and Biostatistics, Lady Davis Institute, Jewish General Hospital, McGill University, Montreal, Quebec H3T 1E2, Canada. Email: hou.zheng@mail.mcgill.ca. 6. Department of Cardiology, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China. Email: wal@ah.edu.cn.
Abstract
BACKGROUND: C-reactive protein (CRP) gene +1059 G/C polymorphism has been reported to be associated with coronary heart disease (CHD) risk, but the results remain inconclusive. This meta-analysis was therefore conducted to clarify these controversies. METHODS: A comprehensive search was conducted to identify all case control studies on the association between CRP gene +1059 G/C polymorphism and CHD risk. All the related studies were further strictly selected according to the inclusion criteria. Meta-analysis was performed with STATA 10.1 (StataCorp, USA). The association was assessed by odds ratio (OR) and 95% confidence interval (CI); both Begg's funnel plot and Egger's regression test were used to assess the publication bias. RESULTS: This meta-analysis on a total of 13 studies comprising 6316 CHD cases and 4467 controls showed no significant association between CRP gene +1059 G/C polymorphism and CHD risk in the overall study (for C/C+C/G vs. G/G: OR = 1.01, 95% CI = 0.81-1.25, P = 0.96; for C/C vs. C/G+G/G: OR = 1.17, 95% CI = 0.77-1.77, P = 0.47; for C/C vs. G/G: OR = 1.17, 95% CI = 0.77-1.77, P = 0.47; for C allele vs. G allele: OR = 1.01, 95% CI = 0.81-1.24, P = 0.96). However, in the subgroup analysis by ethnicity, the results showed significant association between CRP gene +1059 G/C polymorphism and CHD risk among Caucasians (for C/C vs. G/G: OR = 2.54, 95% CI = 1.13-5.72, P = 0.02; C/C vs. C/G+G/G: OR = 2.45, 95% CI = 1.09-5.51, P = 0.03), but not among Asians and Africans (P > 0.05). CONCLUSION: CRP gene +1059 G/C polymorphism may be associated with increased CHD risk among Caucasians and more evidences need to validate the conclusion.
BACKGROUND:C-reactive protein (CRP) gene +1059 G/C polymorphism has been reported to be associated with coronary heart disease (CHD) risk, but the results remain inconclusive. This meta-analysis was therefore conducted to clarify these controversies. METHODS: A comprehensive search was conducted to identify all case control studies on the association between CRP gene +1059 G/C polymorphism and CHD risk. All the related studies were further strictly selected according to the inclusion criteria. Meta-analysis was performed with STATA 10.1 (StataCorp, USA). The association was assessed by odds ratio (OR) and 95% confidence interval (CI); both Begg's funnel plot and Egger's regression test were used to assess the publication bias. RESULTS: This meta-analysis on a total of 13 studies comprising 6316 CHD cases and 4467 controls showed no significant association between CRP gene +1059 G/C polymorphism and CHD risk in the overall study (for C/C+C/G vs. G/G: OR = 1.01, 95% CI = 0.81-1.25, P = 0.96; for C/C vs. C/G+G/G: OR = 1.17, 95% CI = 0.77-1.77, P = 0.47; for C/C vs. G/G: OR = 1.17, 95% CI = 0.77-1.77, P = 0.47; for C allele vs. G allele: OR = 1.01, 95% CI = 0.81-1.24, P = 0.96). However, in the subgroup analysis by ethnicity, the results showed significant association between CRP gene +1059 G/C polymorphism and CHD risk among Caucasians (for C/C vs. G/G: OR = 2.54, 95% CI = 1.13-5.72, P = 0.02; C/C vs. C/G+G/G: OR = 2.45, 95% CI = 1.09-5.51, P = 0.03), but not among Asians and Africans (P > 0.05). CONCLUSION:CRP gene +1059 G/C polymorphism may be associated with increased CHD risk among Caucasians and more evidences need to validate the conclusion.
Authors: Yazmín Hernández-Díaz; Carlos Alfonso Tovilla-Zárate; Isela Juárez-Rojop; Manuel Alfonso Baños-González; Manuel Eduardo Torres-Hernández; María Lilia López-Narváez; Teresa Guadalupe Yañez-Rivera; Thelma Beatriz González-Castro Journal: Int J Clin Exp Med Date: 2015-08-15
Authors: Yazmín Hernández-Díaz; Carlos Alfonso Tovilla-Zárate; Isela Juárez-Rojop; María Lilia López-Narváez; José Francisco Álvarez-Cámara; Thelma Beatriz González-Castro Journal: Int J Environ Res Public Health Date: 2016-01-06 Impact factor: 3.390