Literature DB >> 24341358

Ruthmycin, a new tetracyclic polyketide from Streptomyces sp. RM-4-15.

Xiachang Wang1, Sherif I Elshahawi, Khaled A Shaaban, Lei Fang, Larissa V Ponomareva, Yinan Zhang, Gregory C Copley, James C Hower, Chang-Guo Zhan, Madan K Kharel, Jon S Thorson.   

Abstract

The isolation and structural elucidation of a new tetracyclic polyketide (ruthmycin) from Streptomyces sp. RM-4-15, a bacteria isolated near thermal vents from the Ruth Mullins underground coal mine fire in eastern Kentucky, is reported. In comparison to the well-established frenolicin core scaffold, ruthmycin possesses an unprecedented signature C3 bridge and a corresponding fused six member ring. Preliminary in vitro antibacterial, anticancer, and antifungal assays revealed ruthmycin to display moderate antifungal activity.

Entities:  

Mesh：

Substances：

Year:  2013        PMID： 24341358      PMCID： PMC3964319          DOI： 10.1021/ol4033418

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  17 in total

Review 1.  Antifungal drug resistance in Aspergillus.

Authors:  C B Moore; N Sayers; J Mosquera; J Slaven; D W Denning
Journal:  J Infect       Date:  2000-11       Impact factor: 6.072

2.  UCF76 compounds, new inhibitors of farnesyltransferase produced by Streptomyces.

Authors:  M Hara; S Soga; K Shono; J Eishima; T Mizukami
Journal:  J Antibiot (Tokyo)       Date:  2001-02       Impact factor: 2.649

Review 3.  Pyranonaphthoquinone antibiotics--isolation, structure and biological activity.

Authors:  M A Brimble; L J Duncalf; M R Nairn
Journal:  Nat Prod Rep       Date:  1999-06       Impact factor: 13.423

4.  cclib: a library for package-independent computational chemistry algorithms.

Authors:  Noel M O'Boyle; Adam L Tenderholt; Karol M Langner
Journal:  J Comput Chem       Date:  2008-04-15       Impact factor: 3.376

5.  The structure of frenolicin.

Authors:  G A Ellestad; M P Kunstmann; H A Whaley; E L Patterson
Journal:  J Am Chem Soc       Date:  1968-02-28       Impact factor: 15.419

6.  Herbarone, a rearranged heptaketide derivative from the sea hare associated fungus Torula herbarum.

Authors:  Wan-Li Geng; Xian-You Wang; Tibor Kurtán; Attila Mándi; Hua Tang; Barbara Schulz; Peng Sun; Wen Zhang
Journal:  J Nat Prod       Date:  2012-10-08       Impact factor: 4.050

7.  Production of deoxyfrenolicin and a new antibiotic, frenolicin B by Streptomyces roseofulvus strain AM-3867.

Authors:  Y Iwai; A Kora; Y Takahashi; T Hayashi; J Awaya; R Masuma; R Oiwa; S Omura
Journal:  J Antibiot (Tokyo)       Date:  1978-10       Impact factor: 2.649

8.  Pyranonaphthoquinone lactones: a new class of AKT selective kinase inhibitors alkylate a regulatory loop cysteine.

Authors:  Edward J Salaski; Girija Krishnamurthy; Wei-Dong Ding; Ker Yu; Shabana S Insaf; Clark Eid; Jaechul Shim; Jeremy I Levin; Keiko Tabei; Lourdes Toral-Barza; Wei-Guo Zhang; Leonard A McDonald; Erick Honores; Cilien Hanna; Ayako Yamashita; Bernard Johnson; Zhong Li; Leif Laakso; Dennis Powell; Tarek S Mansour
Journal:  J Med Chem       Date:  2009-04-23       Impact factor: 7.446

9.  Engineered biosynthesis of the antiparasitic agent frenolicin B and rationally designed analogs in a heterologous host.

Authors:  Jay T Fitzgerald; Christian P Ridley; Chaitan Khosla
Journal:  J Antibiot (Tokyo)       Date:  2011-09-21       Impact factor: 2.649

10.  Venturicidin C, a new 20-membered macrolide produced by Streptomyces sp. TS-2-2.

Authors:  Khaled A Shaaban; Shanteri Singh; Sherif I Elshahawi; Xiachang Wang; Larissa V Ponomareva; Manjula Sunkara; Gregory C Copley; James C Hower; Andrew J Morris; Madan K Kharel; Jon S Thorson
Journal:  J Antibiot (Tokyo)       Date:  2013-11-13       Impact factor: 2.649
View more
  14 in total

Review 1.  Leveraging ecological theory to guide natural product discovery.

Authors:  Michael J Smanski; Daniel C Schlatter; Linda L Kinkel
Journal:  J Ind Microbiol Biotechnol       Date:  2015-10-05       Impact factor: 3.346

2.  Mccrearamycins A-D, Geldanamycin-Derived Cyclopentenone Macrolactams from an Eastern Kentucky Abandoned Coal Mine Microbe.

Authors:  Xiachang Wang; Yinan Zhang; Larissa V Ponomareva; Qingchao Qiu; Ryan Woodcock; Sherif I Elshahawi; Xiabin Chen; Ziyuan Zhou; Bruce E Hatcher; James C Hower; Chang-Guo Zhan; Sean Parkin; Madan K Kharel; S Randal Voss; Khaled A Shaaban; Jon S Thorson
Journal:  Angew Chem Int Ed Engl       Date:  2017-01-31       Impact factor: 15.336

3.  Baraphenazines A-G, Divergent Fused Phenazine-Based Metabolites from a Himalayan Streptomyces.

Authors:  Xiachang Wang; Muhammad Abbas; Yinan Zhang; Sherif I Elshahawi; Larissa V Ponomareva; Zheng Cui; Steven G Van Lanen; Imran Sajid; S Randal Voss; Khaled A Shaaban; Jon S Thorson
Journal:  J Nat Prod       Date:  2019-05-22       Impact factor: 4.050

4.  Puromycins B-E, Naturally Occurring Amino-Nucleosides Produced by the Himalayan Isolate Streptomyces sp. PU-14G.

Authors:  Muhammad Abbas; Sherif I Elshahawi; Xiachang Wang; Larissa V Ponomareva; Imran Sajid; Khaled A Shaaban; Jon S Thorson
Journal:  J Nat Prod       Date:  2018-11-12       Impact factor: 4.050

5.  Terfestatins B and C, New p-Terphenyl Glycosides Produced by Streptomyces sp. RM-5-8.

Authors:  Xiachang Wang; Anna R Reynolds; Sherif I Elshahawi; Khaled A Shaaban; Larissa V Ponomareva; Meredith A Saunders; Ibrahim S Elgumati; Yinan Zhang; Gregory C Copley; James C Hower; Manjula Sunkara; Andrew J Morris; Madan K Kharel; Steven G Van Lanen; Mark A Prendergast; Jon S Thorson
Journal:  Org Lett       Date:  2015-05-11       Impact factor: 6.005

6.  Bi- and Tetracyclic Spirotetronates from the Coal Mine Fire Isolate Streptomyces sp. LC-6-2.

Authors:  Xiachang Wang; Sherif I Elshahawi; Wenlong Cai; Yinan Zhang; Larissa V Ponomareva; Xiabin Chen; Gregory C Copley; James C Hower; Chang-Guo Zhan; Sean Parkin; Jürgen Rohr; Steven G Van Lanen; Khaled A Shaaban; Jon S Thorson
Journal:  J Nat Prod       Date:  2017-03-30       Impact factor: 4.050

7.  Spoxazomicin D and Oxachelin C, Potent Neuroprotective Carboxamides from the Appalachian Coal Fire-Associated Isolate Streptomyces sp. RM-14-6.

Authors:  Khaled A Shaaban; Meredith A Saunders; Yinan Zhang; Tuan Tran; Sherif I Elshahawi; Larissa V Ponomareva; Xiachang Wang; Jianjun Zhang; Gregory C Copley; Manjula Sunkara; Madan K Kharel; Andrew J Morris; James C Hower; Matthew S Tremblay; Mark A Prendergast; Jon S Thorson
Journal:  J Nat Prod       Date:  2016-12-28       Impact factor: 4.050

8.  A divergent enantioselective strategy for the synthesis of griseusins.

Authors:  Yinan Zhang; Qing Ye; Xiachang Wang; Qing-Bai She; Jon S Thorson
Journal:  Angew Chem Int Ed Engl       Date:  2015-07-31       Impact factor: 15.336

9.  Structure Determination, Functional Characterization, and Biosynthetic Implications of Nybomycin Metabolites from a Mining Reclamation Site-Associated Streptomyces.

Authors:  Xiachang Wang; Sherif I Elshahawi; Larissa V Ponomareva; Qing Ye; Yang Liu; Gregory C Copley; James C Hower; Bruce E Hatcher; Madan K Kharel; Steven G Van Lanen; Qing-Bai She; S Randal Voss; Jon S Thorson; Khaled A Shaaban
Journal:  J Nat Prod       Date:  2019-12-13       Impact factor: 4.050

10.  Frenolicin B Targets Peroxiredoxin 1 and Glutaredoxin 3 to Trigger ROS/4E-BP1-Mediated Antitumor Effects.

Authors:  Qing Ye; Yinan Zhang; Yanan Cao; Xiachang Wang; Yubin Guo; Jing Chen; Jamie Horn; Larissa V Ponomareva; Luksana Chaiswing; Khaled A Shaaban; Qiou Wei; Bradley D Anderson; Daret K St Clair; Haining Zhu; Markos Leggas; Jon S Thorson; Qing-Bai She
Journal:  Cell Chem Biol       Date:  2019-01-17       Impact factor: 8.116
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.