Literature DB >> 24338877

Activation and retention: a magnetic resonance probe for the detection of acute thrombosis.

Galen S Loving1, Peter Caravan.   

Abstract

Blood-clot formation that results in the complete occlusion of a blood vessel (thrombosis) often leads to serious life-threatening events, such as strokes and heart attacks. As the composition of a thrombus changes as it matures, new imaging methods that are capable of distinguishing new clots from old clots may yield important diagnostic and prognostic information. To address this need, an activatable magnetic resonance (MR) probe that is responsive to a key biochemical process associated with recently formed clots has been developed.
Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  disulfide bonds; enzymatic activation; fibrin; imaging agents; magnetic resonance imaging

Mesh：

Substances：

Year:  2013        PMID： 24338877      PMCID： PMC4041297          DOI： 10.1002/anie.201308607

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  19 in total

1.  In vivo visualization of gene expression using magnetic resonance imaging.

Authors:  A Y Louie; M M Hüber; E T Ahrens; U Rothbächer; R Moats; R E Jacobs; S E Fraser; T J Meade
Journal:  Nat Biotechnol       Date:  2000-03       Impact factor: 54.908

2.  Enzyme-Activated Gd(3+) Magnetic Resonance Imaging Contrast Agents with a Prominent Receptor-Induced Magnetization Enhancement We thank Dr. Shrikumar Nair for helpful discussions.

Authors:  Alexander L. Nivorozhkin; Andrew F. Kolodziej; Peter Caravan; Matthew T. Greenfield; Randall B. Lauffer; Thomas J. McMurry
Journal:  Angew Chem Int Ed Engl       Date:  2001-08-03       Impact factor: 15.336

Review 3.  Platelets and wound healing.

Authors:  Alan T Nurden; Paquita Nurden; Mikel Sanchez; Isabel Andia; Eduardo Anitua
Journal:  Front Biosci       Date:  2008-05-01

4.  Molecular MRI of intracranial thrombus in a rat ischemic stroke model.

Authors:  Ritika Uppal; Ilknur Ay; Guangping Dai; Young Ro Kim; A Gregory Sorensen; Peter Caravan
Journal:  Stroke       Date:  2010-04-15       Impact factor: 7.914

5.  Fibrin-targeted PET probes for the detection of thrombi.

Authors:  Katie L Ciesienski; Yan Yang; Ilknur Ay; Daniel B Chonde; Galen S Loving; Tyson A Rietz; Ciprian Catana; Peter Caravan
Journal:  Mol Pharm       Date:  2013-01-30       Impact factor: 4.939

Review 6.  The role of thiols and disulfides in platelet function.

Authors:  David W Essex
Journal:  Antioxid Redox Signal       Date:  2004-08       Impact factor: 8.401

Review 7.  Protein disulfide isomerase.

Authors:  Bonney Wilkinson; Hiram F Gilbert
Journal:  Biochim Biophys Acta       Date:  2004-06-01

8.  Localization of protein disulfide isomerase to the external surface of the platelet plasma membrane.

Authors:  D W Essex; K Chen; M Swiatkowska
Journal:  Blood       Date:  1995-09-15       Impact factor: 22.113

9.  EP-2104R: a fibrin-specific gadolinium-Based MRI contrast agent for detection of thrombus.

Authors:  Kirsten Overoye-Chan; Steffi Koerner; Richard J Looby; Andrew F Kolodziej; Stephan G Zech; Qing Deng; Jaclyn M Chasse; Thomas J McMurry; Peter Caravan
Journal:  J Am Chem Soc       Date:  2008-04-08       Impact factor: 15.419

10.  Thrombus imaging with fibrin-specific gadolinium-based MR contrast agent EP-2104R: results of a phase II clinical study of feasibility.

Authors:  Josef Vymazal; Elmar Spuentrup; Gerardo Cardenas-Molina; Andrea J Wiethoff; Michael G Hartmann; Peter Caravan; Edward C Parsons
Journal:  Invest Radiol       Date:  2009-11       Impact factor: 6.016
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  8 in total

Review 1.  MR imaging probes: design and applications.

Authors:  Eszter Boros; Eric M Gale; Peter Caravan
Journal:  Dalton Trans       Date:  2015-03-21       Impact factor: 4.390

Review 2.  Chemistry of MRI Contrast Agents: Current Challenges and New Frontiers.

Authors:  Jessica Wahsner; Eric M Gale; Aurora Rodríguez-Rodríguez; Peter Caravan
Journal:  Chem Rev       Date:  2018-10-16       Impact factor: 60.622

3.  Multimodal Molecular Imaging Reveals High Target Uptake and Specificity of 111In- and 68Ga-Labeled Fibrin-Binding Probes for Thrombus Detection in Rats.

Authors:  Bruno L Oliveira; Francesco Blasi; Tyson A Rietz; Nicholas J Rotile; Helen Day; Peter Caravan
Journal:  J Nucl Med       Date:  2015-08-06       Impact factor: 10.057

Review 4.  Peptide-based fibrin-targeting probes for thrombus imaging.

Authors:  Bruno L Oliveira; Peter Caravan
Journal:  Dalton Trans       Date:  2017-10-31       Impact factor: 4.390

5.  Novel anti-thrombotic agent for modulation of protein disulfide isomerase family member ERp57 for prophylactic therapy.

Authors:  Guozhen Cui; Luchen Shan; Lin Guo; Ivan Keung Chu; Guohui Li; Quan Quan; Yun Zhao; Cheong Meng Chong; Zaijun Zhang; Pei Yu; Maggie Pui Man Hoi; Yewei Sun; Yuqiang Wang; Simon MingYuen Lee
Journal:  Sci Rep       Date:  2015-06-03       Impact factor: 4.379

6.  An Activatable T1-Weighted MR Contrast Agent: A Noninvasive Tool for Tracking the Vicinal Thiol Motif of Thioredoxin in Live Cells.

Authors:  Jongeun Kang; Eunha Hwang; Hyunseung Lee; Mi Young Cho; Sanu Karan; Hak Nam Kim; Jong Seung Kim; Jonathan L Sessler; Sankarprasad Bhuniya; Kwan Soo Hong
Journal:  Molecules       Date:  2021-04-01       Impact factor: 4.411

7.  Fibrin-targeting molecular MRI in inflammatory CNS disorders.

Authors:  Johannes Lohmeier; Rafaela V Silva; Anna Tietze; Matthias Taupitz; Takaaki Kaneko; Harald Prüss; Friedemann Paul; Carmen Infante-Duarte; Bernd Hamm; Peter Caravan; Marcus R Makowski
Journal:  Eur J Nucl Med Mol Imaging       Date:  2022-05-04       Impact factor: 10.057

Review 8.  The Design of Abnormal Microenvironment Responsive MRI Nanoprobe and Its Application.

Authors:  Ancong Wang; Xiao Han; Wenliu Qi; Sihui Du; Zhenqi Jiang; Xiaoying Tang
Journal:  Int J Mol Sci       Date:  2021-05-13       Impact factor: 5.923
  8 in total

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