Literature DB >> 2433552

Human thymic and peripheral blood non-MHC-restricted cytotoxic lymphocytes.

L L Lanier, J H Phillips.   

Abstract

We propose that non-MHC-restricted cytotoxicity is mediated by two distinct types of lymphocyte: NK cells and a unique subset of cytotoxic T-lymphocytes (CTLs). Herein, we review experimental data to support the hypothesis that NK cells and non-MHC-restricted CTLs use different recognition structures and arise from distinct lineages. Furthermore, we demonstrate that non-MHC-restricted CTLs can be generated in vitro by culturing thymocytes in recombinant interleukin-2 (rIL-2).

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Year:  1986        PMID： 2433552     DOI： 10.1007/bf02935001

Source DB:  PubMed          Journal:  Med Oncol Tumor Pharmacother        ISSN： 0736-0118


  37 in total

1.  Analysis of T-cell receptor gene rearrangement and expression in human natural killer clones.

Authors:  J Ritz; T J Campen; R E Schmidt; H D Royer; T Hercend; R E Hussey; E L Reinherz
Journal:  Science       Date:  1985-06-28       Impact factor: 47.728

2.  Cross-linking of human T cell receptor proteins: association between the T cell idiotype beta subunit and the T3 glycoprotein heavy subunit.

Authors:  M B Brenner; I S Trowbridge; J L Strominger
Journal:  Cell       Date:  1985-01       Impact factor: 41.582

3.  Requirement for the coexpression of T3 and the T cell antigen receptor on a malignant human T cell line.

Authors:  A Weiss; J D Stobo
Journal:  J Exp Med       Date:  1984-11-01       Impact factor: 14.307

4.  Three-color immunofluorescence analysis of Leu antigens on human peripheral blood using two lasers on a fluorescence-activated cell sorter.

Authors:  M R Loken; L L Lanier
Journal:  Cytometry       Date:  1984-03

5.  The role of interleukin 2 and T11 E rosette antigen in activation and proliferation of human NK clones.

Authors:  R E Schmidt; T Hercend; D A Fox; A Bensussan; G Bartley; J F Daley; S F Schlossman; E L Reinherz; J Ritz
Journal:  J Immunol       Date:  1985-07       Impact factor: 5.422

6.  Human natural killer cells analyzed by B73.1, a monoclonal antibody blocking Fc receptor functions. I. Characterization of the lymphocyte subset reactive with B73.1.

Authors:  B Perussia; S Starr; S Abraham; V Fanning; G Trinchieri
Journal:  J Immunol       Date:  1983-05       Impact factor: 5.422

7.  Identification of a clonally restricted 90 kD heterodimer on two human cloned natural killer cell lines. Its role in cytotoxic effector function.

Authors:  T Hercend; S Meuer; A Brennan; M A Edson; O Acuto; E L Reinherz; S F Schlossman; J Ritz
Journal:  J Exp Med       Date:  1983-11-01       Impact factor: 14.307

8.  A model for the differentiation of human natural killer cells. Studies on the in vitro activation of Leu-11+ granular lymphocytes with a natural killer-sensitive tumor cell, K562.

Authors:  J H Phillips; L L Lanier
Journal:  J Exp Med       Date:  1985-06-01       Impact factor: 14.307

9.  Clonotypic structures involved in antigen-specific human T cell function. Relationship to the T3 molecular complex.

Authors:  S C Meuer; K A Fitzgerald; R E Hussey; J C Hodgdon; S F Schlossman; E L Reinherz
Journal:  J Exp Med       Date:  1983-02-01       Impact factor: 14.307

10.  Interleukin 2 and stimulator lymphoblastoid cells will induce human thymocytes to bind and kill K562 targets.

Authors:  M Torten; N Sidell; S H Golub
Journal:  J Exp Med       Date:  1982-11-01       Impact factor: 14.307
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