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Literature DB >> 2409597

Analysis of T-cell receptor gene rearrangement and expression in human natural killer clones.

J Ritz, T J Campen, R E Schmidt, H D Royer, T Hercend, R E Hussey, E L Reinherz.

Abstract

A series of clones of human natural killer (NK) cells was characterized with respect to expression of the Ti alpha and Ti beta genes of the T-cell receptor. T11+T3+ NK clones contained Ti alpha and Ti beta RNA transcripts and expressed disulfide-linked heterodimers, demonstrating the presence of a functional T-cell receptor. In contrast, T11+T3- NK clones expressed only 1.0-kilobase truncated Ti beta transcripts, without a Ti alpha transcript and no detectable surface Ti protein. Since previous studies demonstrated that Ti beta gene activation precedes Ti alpha gene activation in thymic ontogeny, the T11+T3- NK cells appear to be derived from T-lineage precursors.

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Year: 1985 PMID： 2409597 DOI： 10.1126/science.2409597

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

38 in total

1. Functional surface structures on human natural killer cells.

Authors: R E Schmidt; T Hercend; S F Schlossman; J Ritz
Journal: Klin Wochenschr Date: 1985-12-02

Review 2. Human thymic and peripheral blood non-MHC-restricted cytotoxic lymphocytes.

Authors: L L Lanier; J H Phillips
Journal: Med Oncol Tumor Pharmacother Date: 1986

3. The T11 glycoprotein is functionally linked to a calcium channel in precursor and mature T-lineage cells.

Authors: A Alcover; M J Weiss; J F Daley; E L Reinherz
Journal: Proc Natl Acad Sci U S A Date: 1986-04 Impact factor: 11.205

4. Fc gamma receptor type III (CD16) is included in the zeta NK receptor complex expressed by human natural killer cells.

Authors: P Anderson; M Caligiuri; C O'Brien; T Manley; J Ritz; S F Schlossman
Journal: Proc Natl Acad Sci U S A Date: 1990-03 Impact factor: 11.205

Review 5. T-cell clones and T-cell receptors.

Authors: F W Fitch
Journal: Microbiol Rev Date: 1986-03

6. In vitro induction of HBsAg-specific CD8 CD11 human suppressor T cells.

Authors: V Barnaba; G Ruberti; M Levrero; F Balsano
Journal: Immunology Date: 1987-11 Impact factor: 7.397

7. Generation of non-MHC restricted killing in cultures stimulated with B cells from chronic lymphocytic leukaemia patients: phenotypic characterization of the precursor and effector cells.

Authors: L Matera; R Foa; F Malavasi; G Bellone; A Funaro; F Veglia; D Santoli
Journal: Clin Exp Immunol Date: 1988-05 Impact factor: 4.330