Literature DB >> 24335302

Use of IRF-3 and/or IRF-7 knockout mice to study viral pathogenesis: lessons from a murine retrovirus-induced AIDS model.

Megan A O'Connor1, William R Green.   

Abstract

Interferon regulatory factor (IRF) regulation of the type I interferon response has not been extensively explored in murine retroviral infections. IRF-3(-/-) and select IRF-3/7(-/-) mice were resistant to LP-BM5-induced pathogenesis. However, further analyses strongly suggested that resistance could be attributed to strain 129-specific contamination of the known retrovirus resistance gene Fv1. Therefore, caution should be taken when interpreting phenotypes observed in these knockout mice, as strain 129-derived genetic polymorphisms may explain observed differences.

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Year:  2013        PMID： 24335302      PMCID： PMC3911529          DOI： 10.1128/JVI.02960-13

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  47 in total

1.  Cytolytic CD8+ T cells directed against a cryptic epitope derived from a retroviral alternative reading frame confer disease protection.

Authors:  On Ho; William R Green
Journal:  J Immunol       Date:  2006-02-15       Impact factor: 5.422

Review 2.  IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors.

Authors:  Kenya Honda; Tadatsugu Taniguchi
Journal:  Nat Rev Immunol       Date:  2006-09       Impact factor: 53.106

3.  An alternative translational reading frame encodes an immunodominant retroviral CTL determinant expressed by an immunodeficiency-causing retrovirus.

Authors:  S M Mayrand; D A Schwarz; W R Green
Journal:  J Immunol       Date:  1998-01-01       Impact factor: 5.422

4.  Virus-dependent phosphorylation of the IRF-3 transcription factor regulates nuclear translocation, transactivation potential, and proteasome-mediated degradation.

Authors:  R Lin; C Heylbroeck; P M Pitha; J Hiscott
Journal:  Mol Cell Biol       Date:  1998-05       Impact factor: 4.272

5.  IRF-7 is the master regulator of type-I interferon-dependent immune responses.

Authors:  Kenya Honda; Hideyuki Yanai; Hideo Negishi; Masataka Asagiri; Mitsuharu Sato; Tatsuaki Mizutani; Naoya Shimada; Yusuke Ohba; Akinori Takaoka; Nobuaki Yoshida; Tadatsugu Taniguchi
Journal:  Nature       Date:  2005-03-30       Impact factor: 49.962

6.  Endocytosis of HIV-1 activates plasmacytoid dendritic cells via Toll-like receptor-viral RNA interactions.

Authors:  Anne-Sophie Beignon; Kelli McKenna; Mojca Skoberne; Olivier Manches; Ida DaSilva; Daniel G Kavanagh; Marie Larsson; Robert J Gorelick; Jeffrey D Lifson; Nina Bhardwaj
Journal:  J Clin Invest       Date:  2005-10-13       Impact factor: 14.808

Review 7.  Triggering the interferon response: the role of IRF-3 transcription factor.

Authors:  J Hiscott; P Pitha; P Genin; H Nguyen; C Heylbroeck; Y Mamane; M Algarte; R Lin
Journal:  J Interferon Cytokine Res       Date:  1999-01       Impact factor: 2.607

8.  The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction.

Authors:  X Y Fu; C Schindler; T Improta; R Aebersold; J E Darnell
Journal:  Proc Natl Acad Sci U S A       Date:  1992-08-15       Impact factor: 11.205

Review 9.  Fv1, the mouse retrovirus resistance gene.

Authors:  J P Stoye
Journal:  Rev Sci Tech       Date:  1998-04       Impact factor: 1.181

10.  B cells are required for induction of T cell abnormalities in a murine retrovirus-induced immunodeficiency syndrome.

Authors:  A Cerny; A W Hügin; R R Hardy; K Hayakawa; R M Zinkernagel; M Makino; H C Morse
Journal:  J Exp Med       Date:  1990-01-01       Impact factor: 14.307
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  3 in total

1.  Reciprocal relationship of T regulatory cells and monocytic myeloid-derived suppressor cells in LP-BM5 murine retrovirus-induced immunodeficiency.

Authors:  Megan A O'Connor; Jennifer L Vella; William R Green
Journal:  J Gen Virol       Date:  2015-08-06       Impact factor: 3.891

2.  IRF3 Signaling within the Mouse Stroma Influences Sepsis Pathogenesis.

Authors:  Erica L Heipertz; Jourdan Harper; Dinesh G Goswami; Charlie A Lopez; Jose Nellikappallil; Ruben Zamora; Yoram Vodovotz; Wendy E Walker
Journal:  J Immunol       Date:  2020-11-25       Impact factor: 5.422

3.  Development of transgenic mouse model expressing porcine aminopeptidase N and its susceptibility to porcine epidemic diarrhea virus.

Authors:  Jung-Eun Park; Eui-Soon Park; Jung-Eun Yu; Jaerang Rho; Sarita Paudel; Bang-Hun Hyun; Dong-Kun Yang; Hyun-Jin Shin
Journal:  Virus Res       Date:  2014-12-27       Impact factor: 3.303
  3 in total

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