BACKGROUND: Increased adiposity at birth may identify infants at high risk of developing obesity. Maternal obesity and hyperglycemia in pregnancy are associated with increased neonatal adiposity; however, features of maternal obesity that contribute to increased neonatal adiposity need further study. AIMS: To measure adiposity in neonates of obese and normal-weight women without gestational diabetes to test the hypothesis that obese women have neonates with increased adiposity compared to neonates of normal-weight women. METHODS: Sixty-one pregnant women, with a normal or obese BMI, and their neonates participated in this cross-sectional study at an academic medical center. Neonatal adiposity, expressed as percent body fat (fat mass/body mass), was measured by air displacement plethysmography and cord blood was assayed for biomarkers. RESULTS: Adiposity in neonates of obese and normal-weight mothers did not differ. Stratifying mothers by leptin level showed that neonates born to mothers with higher leptin had significantly higher adiposity (13.2 vs. 11.1%, p = 0.035). In the entire cohort, adiposity positively correlated with cord blood leptin (r = 0.48, p < 0.001) and adiponectin (r = 0.27, p = 0.04) levels. CONCLUSION: Obesity in normoglycemic pregnant women was not associated with increased neonatal adiposity. High maternal leptin levels identified neonates with increased adiposity.
BACKGROUND: Increased adiposity at birth may identify infants at high risk of developing obesity. Maternal obesity and hyperglycemia in pregnancy are associated with increased neonatal adiposity; however, features of maternal obesity that contribute to increased neonatal adiposity need further study. AIMS: To measure adiposity in neonates of obese and normal-weight women without gestational diabetes to test the hypothesis that obesewomen have neonates with increased adiposity compared to neonates of normal-weight women. METHODS: Sixty-one pregnant women, with a normal or obese BMI, and their neonates participated in this cross-sectional study at an academic medical center. Neonatal adiposity, expressed as percent body fat (fat mass/body mass), was measured by air displacement plethysmography and cord blood was assayed for biomarkers. RESULTS: Adiposity in neonates of obese and normal-weight mothers did not differ. Stratifying mothers by leptin level showed that neonates born to mothers with higher leptin had significantly higher adiposity (13.2 vs. 11.1%, p = 0.035). In the entire cohort, adiposity positively correlated with cord blood leptin (r = 0.48, p < 0.001) and adiponectin (r = 0.27, p = 0.04) levels. CONCLUSION:Obesity in normoglycemic pregnant women was not associated with increased neonatal adiposity. High maternal leptin levels identified neonates with increased adiposity.
Authors: L Pereira-da-Silva; C Cabo; A C Moreira; A L Papoila; D Virella; R Neves; K M Bridges; G Cordeiro-Ferreira Journal: J Perinatol Date: 2014-10-16 Impact factor: 2.521
Authors: Brianna F Moore; Kylie K Harrall; Katherine A Sauder; Deborah H Glueck; Dana Dabelea Journal: Pediatrics Date: 2020-08-13 Impact factor: 7.124
Authors: Jasper Most; Abby D Altazan; Daniel S Hsia; Robbie A Beyl; Leanne M Redman Journal: Obesity (Silver Spring) Date: 2019-12-31 Impact factor: 5.002
Authors: Dawn X P Koh; Mya Thway Tint; Peter D Gluckman; Yap Seng Chong; Fabian K P Yap; Anqi Qiu; Johan G Eriksson; Marielle V Fortier; Patricia P Silveira; Michael J Meaney; Ai Peng Tan Journal: Int J Obes (Lond) Date: 2021-07-19 Impact factor: 5.095