OBJECTIVE: The objective was to compare dual-energy x-ray absorptiometry-measured body composition between large (LGA) and appropriate (AGA) birth weight for gestational age neonates. STUDY DESIGN: LGA term infants (n = 47) with birth weights > or =4000 g were compared with 47 gestational age-matched AGA infants; 11 LGA infants were born to mothers with gestational (9) or pregestational diabetes (2). Dual-energy x-ray absorptiometry scans were performed at 1.8 +/- 1.0 days after birth. RESULTS: Body weight and length were the dominant predictors of body composition in LGA and AGA neonates. However, LGA neonates had significantly (P <.001, all comparisons) higher absolute amounts of total body fat, lean body mass, and bone mineral content and had significantly (P <.001, all comparisons) higher proportions of total body fat and bone mineral content but lower lean body mass as a percent of body weight. The changes for total body fat and lean body mass as a percent of body weight were greatest (P <.001) in LGA infants whose mothers had impaired glucose tolerance. CONCLUSION: LGA neonates have higher body fat and lower lean body mass than AGA infants. Impaired maternal glucose tolerance exaggerated these body composition changes.
OBJECTIVE: The objective was to compare dual-energy x-ray absorptiometry-measured body composition between large (LGA) and appropriate (AGA) birth weight for gestational age neonates. STUDY DESIGN:LGA term infants (n = 47) with birth weights > or =4000 g were compared with 47 gestational age-matched AGA infants; 11 LGAinfants were born to mothers with gestational (9) or pregestational diabetes (2). Dual-energy x-ray absorptiometry scans were performed at 1.8 +/- 1.0 days after birth. RESULTS: Body weight and length were the dominant predictors of body composition in LGA and AGA neonates. However, LGA neonates had significantly (P <.001, all comparisons) higher absolute amounts of total body fat, lean body mass, and bone mineral content and had significantly (P <.001, all comparisons) higher proportions of total body fat and bone mineral content but lower lean body mass as a percent of body weight. The changes for total body fat and lean body mass as a percent of body weight were greatest (P <.001) in LGAinfants whose mothers had impaired glucose tolerance. CONCLUSION:LGA neonates have higher body fat and lower lean body mass than AGA infants. Impaired maternal glucose tolerance exaggerated these body composition changes.
Authors: Reeti Chawla; Sylvia E Badon; Janani Rangarajan; Anna C Reisetter; Loren L Armstrong; Lynn P Lowe; Margrit Urbanek; Boyd E Metzger; M Geoffrey Hayes; Denise M Scholtens; William L Lowe Journal: J Clin Endocrinol Metab Date: 2014-08-19 Impact factor: 5.958
Authors: Nuermaimaiti Tuersunjiang; John F Odhiambo; Nathan M Long; Desiree R Shasa; Peter W Nathanielsz; Stephen P Ford Journal: Am J Physiol Endocrinol Metab Date: 2013-08-06 Impact factor: 4.310
Authors: P A Bommarito; B M Welch; A P Keil; G P Baker; D E Cantonwine; T F McElrath; K K Ferguson Journal: Environ Health Date: 2021-06-10 Impact factor: 5.984