Literature DB >> 24334688

A nonadjuvanted transcutaneous tetanus patch is effective in boosting anti-tetanus toxoid immune responses.

Robert C Seid1, Christoph Reinisch, Robert Schlegl, Michael Moehlen, Andreas Meinke, Urban Lundberg.   

Abstract

Dry tetanus toxoid (TTx) patches were formulated without any adjuvant, with excipients to impart antigen stabilization and to enhance skin delivery. The booster effects of the TTx patches were assessed using a guinea pig model. The study revealed significant rises in TTx IgG titers induced by the TTx patches after a low-dose subcutaneous (s.c.) prime with TTx adsorbed to aluminum hydroxide. The TTx patch can therefore be considered an effective alternative to a subcutaneous booster.

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Year:  2013        PMID： 24334688      PMCID： PMC3910942          DOI： 10.1128/CVI.00638-13

Source DB:  PubMed          Journal:  Clin Vaccine Immunol        ISSN： 1556-679X


  7 in total

1.  Public health. Grand Challenges in Global Health.

Authors:  H Varmus; R Klausner; E Zerhouni; T Acharya; A S Daar; P A Singer
Journal:  Science       Date:  2003-10-17       Impact factor: 47.728

Review 2.  Transcutaneous immunization with Intercell's vaccine delivery system.

Authors:  Robert C Seid; Jee Loon Look; Christian Ruiz; Vladimir Frolov; David Flyer; Jason Schafer; Larry Ellingsworth
Journal:  Vaccine       Date:  2012-06-19       Impact factor: 3.641

3.  Transcutaneous immunization with a Vibrio cholerae O1 Ogawa synthetic hexasaccharide conjugate following oral whole-cell cholera vaccination boosts vibriocidal responses and induces protective immunity in mice.

Authors:  A A Tarique; A Kalsy; M Arifuzzaman; S M Rollins; R C Charles; D T Leung; J B Harris; R C Larocque; A Sheikh; M S Bhuiyan; R Saksena; J D Clements; S B Calderwood; F Qadri; P Kovác; E T Ryan
Journal:  Clin Vaccine Immunol       Date:  2012-02-22

4.  Effect of homologous and heterologous prime-boost on the immune response to recombinant plague antigens.

Authors:  Audrey Glynn; Lucy C Freytag; John D Clements
Journal:  Vaccine       Date:  2005-03-14       Impact factor: 3.641

5.  Transcutaneous immunization: a human vaccine delivery strategy using a patch.

Authors:  G M Glenn; D N Taylor; X Li; S Frankel; A Montemarano; C R Alving
Journal:  Nat Med       Date:  2000-12       Impact factor: 53.440

6.  Transcutaneous immunization with bacterial ADP-ribosylating exotoxins, subunits, and unrelated adjuvants.

Authors:  T Scharton-Kersten; J m Yu; R Vassell; D O'Hagan; C R Alving; G M Glenn
Journal:  Infect Immun       Date:  2000-09       Impact factor: 3.441

7.  Transcutaneous delivery and thermostability of a dry trivalent inactivated influenza vaccine patch.

Authors:  Vladimir G Frolov; Robert C Seid; Olabisi Odutayo; Mohammad Al-Khalili; Jianmei Yu; Olga Y Frolova; Hong Vu; Barbara A Butler; Jee Loon Look; Larry R Ellingsworth; Gregory M Glenn
Journal:  Influenza Other Respir Viruses       Date:  2008-03       Impact factor: 4.380
  7 in total

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