| Literature DB >> 11100128 |
G M Glenn1, D N Taylor, X Li, S Frankel, A Montemarano, C R Alving.
Abstract
Transcutaneous immunization, a topical vaccine application, combines the advantages of needle-free delivery while targeting the immunologically rich milieu of the skin. In animal studies, this simple technique induces robust systemic and mucosal antibodies against vaccine antigens. Here, we demonstrate safe application of a patch containing heat-labile enterotoxin (LT, derived from Escherichia coli) to humans, resulting in robust LT-antibody responses. These findings indicate that TCI is feasible for human immunization, and suggest that TCI may enhance efficacy as well as improve vaccine delivery.Entities:
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Year: 2000 PMID： 11100128 DOI： 10.1038/82225
Source DB: PubMed Journal: Nat Med ISSN： 1078-8956 Impact factor: 53.440