Ana Maria Baptista Menezes1, Adriana Muiño2, Maria Victorina López-Varela3, Gonzalo Valdivia4, Carmen Lisboa4, José Roberto Jardim5, Maria Montes de Oca6, Carlos Tálamo6, Fernando César Wehrmeister7, Rogelio Perez-Padilla8. 1. Post-Graduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brasil. Electronic address: anamene@terra.com.br. 2. Departamento de Neumología, Centro Hospitalario Pereira Rossell, Montevideo, Uruguay. 3. Facultad de Medicina, Universidad de la República, Montevideo, Uruguay. 4. Escuela de Medicina, Universidad Católica de Santiago, Santiago, Chile. 5. Departamento de Neumología, Federal University of São Paulo, São Paulo, Brasil. 6. Facultad de Medicina, Universidad Central de Venezuela, Caracas, Venezuela. 7. Post-Graduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brasil. 8. Instituto Nacional de Enfermedades Respiratorias, Ciudad de México, México.
Abstract
BACKGROUND: The PLATINO baseline study, conducted from 2003-2005 in five Latin American cities (São Paulo, Mexico City, Montevideo, Santiago, Caracas), showed a high prevalence of chronic obstructive pulmonary disease (COPD). METHODS/ DESIGN: A follow-up study was conducted in three out of the five centers (Montevideo, Santiago, and São Paulo) after a period of 5, 6 and 9years, respectively, aimed at verifying the stability of the COPD diagnosis over time, the evolution of the disease in terms of survival, morbidity and respiratory function, and the analyses of inflammatory and genetic biomarkers in the blood. Some questions were added to the original questionnaire and death certificates were obtained from the national official registries. RESULTS: The fieldwork has been concluded in the three centers. From the original samples in the PLATINO study phasei, we were able to locate and interview 85.6% of patients in Montevideo, 84.7% in Santiago and 77.7% in São Paulo. Individuals who could not be located had higher education levels in Brazil, and were more likely to be current smokers in Santiago and São Paulo than in Montevideo. The overall quality of spirometries was ≥80% according to American Thoracic Society criteria. The number of deaths was 71 (Montevideo), 95 (Santiago) and 135 (São Paulo), with death certificates obtained from the national mortality registries for 76.1%, 88.3% and 91.8% of cases in Montevideo, Santiago and São Paulo, respectively. CONCLUSIONS: This study shows that is possible to perform population-based longitudinal studies in Latin American with high follow-up rates and high-quality spirometry data. The adequacy of national mortality registries varies among centers in Latin America.
BACKGROUND: The PLATINO baseline study, conducted from 2003-2005 in five Latin American cities (São Paulo, Mexico City, Montevideo, Santiago, Caracas), showed a high prevalence of chronic obstructive pulmonary disease (COPD). METHODS/ DESIGN: A follow-up study was conducted in three out of the five centers (Montevideo, Santiago, and São Paulo) after a period of 5, 6 and 9years, respectively, aimed at verifying the stability of the COPD diagnosis over time, the evolution of the disease in terms of survival, morbidity and respiratory function, and the analyses of inflammatory and genetic biomarkers in the blood. Some questions were added to the original questionnaire and death certificates were obtained from the national official registries. RESULTS: The fieldwork has been concluded in the three centers. From the original samples in the PLATINO study phasei, we were able to locate and interview 85.6% of patients in Montevideo, 84.7% in Santiago and 77.7% in São Paulo. Individuals who could not be located had higher education levels in Brazil, and were more likely to be current smokers in Santiago and São Paulo than in Montevideo. The overall quality of spirometries was ≥80% according to American Thoracic Society criteria. The number of deaths was 71 (Montevideo), 95 (Santiago) and 135 (São Paulo), with death certificates obtained from the national mortality registries for 76.1%, 88.3% and 91.8% of cases in Montevideo, Santiago and São Paulo, respectively. CONCLUSIONS: This study shows that is possible to perform population-based longitudinal studies in Latin American with high follow-up rates and high-quality spirometry data. The adequacy of national mortality registries varies among centers in Latin America.
Authors: Jose Luis Lopez-Campos; Luis Jara-Palomares; Xavier Muñoz; Víctor Bustamante; Esther Barreiro Journal: Ann Thorac Med Date: 2015 Apr-Jun Impact factor: 2.219
Authors: Rogelio Perez-Padilla; Fernando C Wehrmeister; Maria Montes de Oca; Maria Victorina Lopez; Jose R Jardim; Adriana Muino; Gonzalo Valdivia; Julio Pertuze; Ana Maria B Menezes Journal: PLoS One Date: 2015-03-26 Impact factor: 3.240
Authors: Rogelio Pérez-Padilla; Rosario Fernandez-Plata; Maria Montes de Oca; Maria Victorina Lopez-Varela; Jose R Jardim; Adriana Muiño; Gonzalo Valdivia; Ana Maria B Menezes Journal: PLoS One Date: 2017-05-04 Impact factor: 3.240
Authors: Ana M Menezes; Fernando C Wehrmeister; Rogelio Perez-Padilla; Karynna P Viana; Claudia Soares; Hana Müllerova; Gonzalo Valdivia; José R Jardim; Maria Montes de Oca Journal: Int J Chron Obstruct Pulmon Dis Date: 2017-05-18
Authors: Rogelio Perez-Padilla; Fernando C Wehrmeister; Maria Montes de Oca; Maria Victorina Lopez; Jose R Jardim; Adriana Muiño; Gonzalo Valdivia; Ana Maria B Menezes Journal: Int J Chron Obstruct Pulmon Dis Date: 2018-10-26
Authors: Ana Maria B Menezes; Rogelio Pérez-Padilla; Fernando César Wehrmeister; Maria Victorina Lopez-Varela; Adriana Muiño; Gonzalo Valdivia; Carmen Lisboa; José Roberto B Jardim; Maria Montes de Oca; Carlos Talamo; Renata Bielemann; Mariana Gazzotti; Ruy Laurenti; Bartolomé Celli; Cesar G Victora Journal: PLoS One Date: 2014-10-06 Impact factor: 3.240