Literature DB >> 24332629

Verrulactone C with an unprecedented dispiro skeleton, a new inhibitor of Staphylococcus aureus enoyl-ACP reductase, from Penicillium verruculosum F375.

Nyung Kim1, Mi-Jin Sohn1, Hiroyuki Koshino2, Eun-Hee Kim3, Won-Gon Kim4.   

Abstract

An highly quaternary and unprecedented dispiro compound, verrulactone C, with the known compound, altenuisol, were isolated from a culture broth of the fungal strain Penicillium verruculosum F375 and their structures were established by various spectral analysis. Verrulactone C and altenuisol showed FabI-selective inhibition. Especially altenuisol had the high correlation between FabI-inhibition and whole cell antibacterial activity against Staphylococcus aureus and MRSA with MICs of 8-32μg/mL.
Copyright © 2013 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Antibacterial; Dispiro; FabI; S. aureus

Mesh：

Substances：

Year:  2013        PMID： 24332629     DOI： 10.1016/j.bmcl.2013.11.071

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  5 in total

1.  Verrulactones D and E with unprecedented skeletons, new inhibitors of Staphylococcus aureus enoyl-ACP reductase, from Penicillium verruculosum F375.

Authors:  Nyung Kim; Mi-Jin Sohn; Hiroyuki Koshino; Won-Gon Kim
Journal:  J Antibiot (Tokyo)       Date:  2015-08-26       Impact factor: 2.649

Review 2.  Mining Fatty Acid Biosynthesis for New Antimicrobials.

Authors:  Christopher D Radka; Charles O Rock
Journal:  Annu Rev Microbiol       Date:  2022-06-01       Impact factor: 16.232

3.  Two New Sulfate-Modified Dibenzopyrones With Anti-foodborne Bacteria Activity From Sponge-Derived Fungus Alternaria sp. SCSIOS02F49.

Authors:  Yaping Chen; Chuanna Liu; Kaliaperumal Kumaravel; Lihong Nan; Yongqi Tian
Journal:  Front Microbiol       Date:  2022-05-04       Impact factor: 6.064

4.  Perylenequione Derivatives with Anticancer Activities Isolated from the Marine Sponge-Derived Fungus, Alternaria sp. SCSIO41014.

Authors:  Xiaoyan Pang; Xiuping Lin; Pei Wang; Xuefeng Zhou; Bin Yang; Junfeng Wang; Yonghong Liu
Journal:  Mar Drugs       Date:  2018-08-14       Impact factor: 5.118

5.  Phytotoxicity and anti-phytopathogenic activities of marine-derived fungi and their secondary metabolites.

Authors:  Rui-Huan Huang; Jian-Yu Gou; Dong-Lin Zhao; Dan Wang; Jing Liu; Guo-Yong Ma; Yi-Qiang Li; Cheng-Sheng Zhang
Journal:  RSC Adv       Date:  2018-11-08       Impact factor: 4.036
  5 in total

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