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Literature DB >> 24332482

Contributions of B cells to lupus pathogenesis.

Allison Sang¹, Ying-Yi Zheng¹, Laurence Morel².

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the production of autoantibodies. This review summarizes first the results obtained in the mouse that have revealed how B cell tolerance is breached in SLE. We then review the B cell subsets, in addition to the autoAb producing cells, which contribute to SLE pathogenesis, focusing on marginal zone B cells, B-1 cells and regulatory B cells. Finally, we review the interactions between B cells and other immune cells that have been implicated in SLE, such as dendritic cells, macrophages, neutrophils and T cells.

Entities: CellLine Chemical Disease Gene Mutation Species

Keywords: Autoimmunity; B cells; Lupus

Mesh：

Substances：
Autoantibodies

Year: 2013 PMID： 24332482 PMCID： PMC4053496 DOI： 10.1016/j.molimm.2013.11.013

Source DB: PubMed Journal: Mol Immunol ISSN： 0161-5890 Impact factor: 4.407

177 in total

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Journal: J Exp Med Date: 2000-12-04 Impact factor: 14.307

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Journal: J Exp Med Date: 2000-12-04 Impact factor: 14.307

30 in total

1. Autoreactive helper T cells alleviate the need for intrinsic TLR signaling in autoreactive B cell activation.

Authors: Josephine R Giles; Adriana Turqueti Neves; Ann Marshak-Rothstein; Mark J Shlomchik
Journal: JCI Insight Date: 2017-02-23

Review 2. The long and the short of it: insights into the cellular source of autoantibodies as revealed by B cell depletion therapy.

Authors: Malika Hale; David J Rawlings; Shaun W Jackson
Journal: Curr Opin Immunol Date: 2018-11-01 Impact factor: 7.486

Review 3. Genetics and pathogenesis of systemic lupus erythematosus and lupus nephritis.

Authors: Chandra Mohan; Chaim Putterman
Journal: Nat Rev Nephrol Date: 2015-03-31 Impact factor: 28.314

Review 4. What rheumatologists need to know about innate lymphocytes.

Authors: Mark A Exley; George C Tsokos; Kingston H G Mills; Dirk Elewaut; Ben Mulhearn
Journal: Nat Rev Rheumatol Date: 2016-09-02 Impact factor: 20.543

Review 5. Metabolic Factors that Contribute to Lupus Pathogenesis.

Authors: Wei Li; Ramya Sivakumar; Anton A Titov; Seung-Chul Choi; Laurence Morel
Journal: Crit Rev Immunol Date: 2016 Impact factor: 2.214

6. Sustained B cell depletion by CD19-targeted CAR T cells is a highly effective treatment for murine lupus.

Authors: Rita Kansal; Noah Richardson; Indira Neeli; Saleem Khawaja; Damian Chamberlain; Marium Ghani; Qurat-Ul-Ain Ghani; Louisa Balazs; Sarka Beranova-Giorgianni; Francesco Giorgianni; James N Kochenderfer; Tony Marion; Lorraine M Albritton; Marko Radic
Journal: Sci Transl Med Date: 2019-03-06 Impact factor: 17.956