OBJECTIVE: The purpose of this study was to compare secondary intention healing of oral soft tissues after laser surgery with and without the use of a compound containing amino acids and sodium hyaluronate. BACKGROUND DATA: Sodium hyaluronate has been successfully used in medicine to promote healing. It has not been studied in the healing of laser-produced wounds. MATERIALS AND METHODS:Excisional biopsy was performed in oral soft tissues with a potassium-titanyl-phosphate (KTP) laser (532 nm, SmartLite, DEKA, Florence, Italy) in 49 patients divided into two groups. In the study group (SG), 31 patients received a compound gel containing four amino acids and sodium hyaluronate (Aminogam(®), Errekappa, Italy) after laser surgery; in the control group (CG), 18 subjects receivedno treatment involving a drug or gel. Numeric rating scale (NRS) was used to evaluate pain experienced after surgery [pain index (PI)]. Using a grid as a benchmark and computer software, the lesion area was measured after surgery (T0) and after 7 days (T1). A percentage healing index (PHI) was calculated indicating healing extension in 7 days. RESULTS: SG cases showed an average PHI of 64.38±26.50, whereas the average PHI in the CG was 47.88%±27.84. Mean PI was 2.67±0.96 for SG and 2.75±0.86 for CG. A statistically significant difference was detected between the groups for PHI (p=0.0447), whereas no difference was detectable for PI (p=0.77). CONCLUSIONS: The use of a gel containing amino acids and sodium hyaluronate can promote faster healing via secondary intention in laser-induced wounds, although it does not seem to affect pain perception.
RCT Entities:
OBJECTIVE: The purpose of this study was to compare secondary intention healing of oral soft tissues after laser surgery with and without the use of a compound containing amino acids and sodium hyaluronate. BACKGROUND DATA: Sodium hyaluronate has been successfully used in medicine to promote healing. It has not been studied in the healing of laser-produced wounds. MATERIALS AND METHODS: Excisional biopsy was performed in oral soft tissues with a potassium-titanyl-phosphate (KTP) laser (532 nm, SmartLite, DEKA, Florence, Italy) in 49 patients divided into two groups. In the study group (SG), 31 patients received a compound gel containing four amino acids and sodium hyaluronate (Aminogam(®), Errekappa, Italy) after laser surgery; in the control group (CG), 18 subjects received no treatment involving a drug or gel. Numeric rating scale (NRS) was used to evaluate pain experienced after surgery [pain index (PI)]. Using a grid as a benchmark and computer software, the lesion area was measured after surgery (T0) and after 7 days (T1). A percentage healing index (PHI) was calculated indicating healing extension in 7 days. RESULTS: SG cases showed an average PHI of 64.38±26.50, whereas the average PHI in the CG was 47.88%±27.84. Mean PI was 2.67±0.96 for SG and 2.75±0.86 for CG. A statistically significant difference was detected between the groups for PHI (p=0.0447), whereas no difference was detectable for PI (p=0.77). CONCLUSIONS: The use of a gel containing amino acids and sodium hyaluronate can promote faster healing via secondary intention in laser-induced wounds, although it does not seem to affect pain perception.
Authors: Manuele Casale; Antonio Moffa; Paola Vella; Lorenzo Sabatino; Francesco Capuano; Beatrice Salvinelli; Michele Antonio Lopez; Francesco Carinci; Fabrizio Salvinelli Journal: Int J Immunopathol Pharmacol Date: 2016-06-08 Impact factor: 3.219
Authors: P Bargiela-Pérez; J González-Merchan; R Díaz-Sanchez; M-A Serrera-Figallo; G Volland; M Joergens; J-L Gutiérrez-Perez; D Torres-Lagares Journal: Med Oral Patol Oral Cir Bucal Date: 2018-01-01
Authors: Karol P Steckiewicz; Piotr Cieciórski; Ewelina Barcińska; Maciej Jaśkiewicz; Magdalena Narajczyk; Marta Bauer; Wojciech Kamysz; Elżbieta Megiel; Iwona Inkielewicz-Stepniak Journal: Int J Nanomedicine Date: 2022-02-02