Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 High yield and high specific activity synthesis of [18F]fallypride in a batch microfluidic reactor for micro-PET imaging.

Literature DB >> 24326303

High yield and high specific activity synthesis of [18F]fallypride in a batch microfluidic reactor for micro-PET imaging.

Muhammad Rashed Javed¹, Supin Chen, Jack Lei, Jeffrey Collins, Maxim Sergeev, Hee-Kwon Kim, Chang-Jin Kim, R Michael van Dam, Pei Yuin Keng.

Abstract

[(18)F]fallypride was synthesized in a batch microfluidic chip with a radiochemical yield of 65 ± 6% (n = 7) and an average specific activity of 730 GBq μmol(-1) (20 Ci μmol(-1)) (n = 4). Specific activity was ~2-fold higher than [(18)F]fallypride synthesized in a macroscale radiosynthesizer, despite starting with significantly less radioactivity, and thus safer conditions, in the microchip.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2014 PMID： 24326303 PMCID： PMC4479166 DOI： 10.1039/c3cc47616b

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

16 in total

1. Micro-chemical synthesis of molecular probes on an electronic microfluidic device.

Authors: Pei Yuin Keng; Supin Chen; Huijiang Ding; Saman Sadeghi; Gaurav J Shah; Alex Dooraghi; Michael E Phelps; Nagichettiar Satyamurthy; Arion F Chatziioannou; Chang-Jin Kim; R Michael van Dam
Journal: Proc Natl Acad Sci U S A Date: 2011-12-30 Impact factor: 11.205

2. Highly efficient production of [(18)F]fallypride using small amounts of base concentration.

Authors: Byung Seok Moon; Jun Hyung Park; Hong Jin Lee; Ji Sun Kim; Hee Sup Kil; Byoung Se Lee; Dae Yoon Chi; Byung Chul Lee; Yu Kyeong Kim; Sang Eun Kim
Journal: Appl Radiat Isot Date: 2010-06-22 Impact factor: 1.513

Review 3. Microreactors for radiopharmaceutical synthesis.

Authors: Arkadij M Elizarov
Journal: Lab Chip Date: 2009-03-26 Impact factor: 6.799

4. Stoichiometric leverage: rapid 18F-aryltrifluoroborate radiosynthesis at high specific activity for click conjugation.

Authors: Zhibo Liu; Ying Li; Jerome Lozada; Paul Schaffer; Michael J Adam; Thomas J Ruth; David M Perrin
Journal: Angew Chem Int Ed Engl Date: 2013-01-11 Impact factor: 15.336

Review 5. Microfluidics in radiopharmaceutical chemistry.

Authors: Giancarlo Pascali; Paul Watts; Piero A Salvadori
Journal: Nucl Med Biol Date: 2013-05-14 Impact factor: 2.408

6. On-demand droplet loading for automated organic chemistry on digital microfluidics.

Authors: Gaurav J Shah; Huijiang Ding; Saman Sadeghi; Supin Chen; Chang-Jin C J Kim; R Michael van Dam
Journal: Lab Chip Date: 2013-07-21 Impact factor: 6.799

7. Automated synthesis and purification of [18F]bromofluoromethane at high specific radioactivity.

Authors: J Bergman; O Eskola; P Lehikoinen; O Solin
Journal: Appl Radiat Isot Date: 2001-06 Impact factor: 1.513

8. A new class of SN2 reactions catalyzed by protic solvents: Facile fluorination for isotopic labeling of diagnostic molecules.

Authors: Dong Wook Kim; Doo-Sik Ahn; Young-Ho Oh; Sungyul Lee; Hee Seup Kil; Seung Jun Oh; Sang Ju Lee; Jae Seung Kim; Jin Sook Ryu; Dae Hyuk Moon; Dae Yoon Chi
Journal: J Am Chem Soc Date: 2006-12-20 Impact factor: 15.419

9. Batch-reactor microfluidic device: first human use of a microfluidically produced PET radiotracer.

Authors: Artem Lebedev; Reza Miraghaie; Kishore Kotta; Carroll E Ball; Jianzhong Zhang; Monte S Buchsbaum; Hartmuth C Kolb; Arkadij Elizarov
Journal: Lab Chip Date: 2012-11-07 Impact factor: 6.799

10. Fluorinated benzamide neuroleptics--III. Development of (S)-N-[(1-allyl-2-pyrrolidinyl)methyl]-5-(3-[18F]fluoropropyl)-2, 3-dimethoxybenzamide as an improved dopamine D-2 receptor tracer.

Authors: J Mukherjee; Z Y Yang; M K Das; T Brown
Journal: Nucl Med Biol Date: 1995-04 Impact factor: 2.408

14 in total

1. Performing radiosynthesis in microvolumes to maximize molar activity of tracers for positron emission tomography.

Authors: Maxim E Sergeev; Mark Lazari; Federica Morgia; Jeffrey Collins; Muhammad Rashed Javed; Olga Sergeeva; Jason Jones; Michael E Phelps; Jason T Lee; Pei Yuin Keng; R Michael van Dam
Journal: Commun Chem Date: 2018-03-22

2. Ultra-compact, automated microdroplet radiosynthesizer.

Authors: Jia Wang; Philip H Chao; R Michael van Dam
Journal: Lab Chip Date: 2019-06-12 Impact factor: 6.799

3. Titania-catalyzed radiofluorination of tosylated precursors in highly aqueous medium.

Authors: Maxim E Sergeev; Federica Morgia; Mark Lazari; Christopher Wang; R Michael van Dam
Journal: J Am Chem Soc Date: 2015-04-22 Impact factor: 15.419

4. Cerenkov Luminescence Imaging in the Development and Production of Radiopharmaceuticals.

Authors: R Michael van Dam; Arion F Chatziioannou
Journal: Front Phys Date: 2021-03-03

5. On-demand radiosynthesis of N-succinimidyl-4-[¹⁸F]fluorobenzoate ([¹⁸F]SFB) on an electrowetting-on-dielectric microfluidic chip for ¹⁸F-labeling of protein.

Authors: Hee-Kwon Kim; Muhammad Rashed Javed; Supin Chen; Kirstin A Zettlitz; Jeffrey Collins; Anna M Wu; Chang-Jin C J Kim; R Michael van Dam; Pei Yuin Keng
Journal: RSC Adv Date: 2019-10-09 Impact factor: 4.036

6. Digital Microfluidics: A New Paradigm for Radiochemistry.

Authors: Pei Yuin Keng; R Michael van Dam
Journal: Mol Imaging Date: 2015-12-05 Impact factor: 4.488

7. New Dioxaborolane Chemistry Enables [(18)F]-Positron-Emitting, Fluorescent [(18)F]-Multimodality Biomolecule Generation from the Solid Phase.

Authors: Erik A Rodriguez; Ye Wang; Jessica L Crisp; David R Vera; Roger Y Tsien; Richard Ting
Journal: Bioconjug Chem Date: 2016-04-27 Impact factor: 4.774

8. Microscale radiosynthesis, preclinical imaging and dosimetry study of [¹⁸F]AMBF₃-TATE: A potential PET tracer for clinical imaging of somatostatin receptors.

Authors: Ksenia Lisova; Maxim Sergeev; Susan Evans-Axelsson; Andreea D Stuparu; Seval Beykan; Jeffrey Collins; Jason Jones; Michael Lassmann; Ken Herrmann; David Perrin; Jason T Lee; Roger Slavik; R Michael van Dam
Journal: Nucl Med Biol Date: 2018-04-20 Impact factor: 2.408

9. Multi-GBq production of the radiotracer [¹⁸F]fallypride in a droplet microreactor.

Authors: Jia Wang; Philip H Chao; Roger Slavik; R Michael van Dam
Journal: RSC Adv Date: 2020-02-24 Impact factor: 4.036

10. Improved synthesis of [¹⁸F] fallypride and characterization of a Huntington's disease mouse model, zQ175DN KI, using longitudinal PET imaging of D2/D3 receptors.

Authors: Tuulia Huhtala; Pekka Poutiainen; Jussi Rytkönen; Kimmo Lehtimäki; Teija Parkkari; Iiris Kasanen; Anu J Airaksinen; Teija Koivula; Patrick Sweeney; Outi Kontkanen; John Wityak; Celia Dominiquez; Larry C Park
Journal: EJNMMI Radiopharm Chem Date: 2019-08-05