Linda G Park1, Jill Howie-Esquivel2, Misook L Chung3, Kathleen Dracup2. 1. San Francisco VA Medical Center, Division of Geriatrics, Palliative and Extended Care, USA. Electronic address: linda.park@ucsf.edu. 2. Department of Physiological Nursing, University of California, San Francisco, USA. 3. College of Nursing, University of Kentucky, USA.
Abstract
OBJECTIVE:Pharmacologic treatment for secondary prevention of coronary heart disease (CHD) is critical to prevent adverse clinical outcomes. In a randomized controlled trial, we compared antiplatelet and statin adherence among patients with CHD who received: (1) text messages (TM) for medication reminders and education, (2) educational TM only, or (3) No TM. METHODS: A mobile health intervention delivered customized TM for 30 days. We assessed and analyzed medication adherence with electronic monitoring devices [Medication Event Monitoring System (MEMS)] by one-way ANOVA and Welch tests, two-way TM response rates by t-tests, and self-reported adherence (Morisky Medication Adherence Scale) by Repeated Measures ANOVA. RESULTS: Among 90 patients (76% male, mean age 59.2 years), MEMS revealed patients who received TM for antiplatelets had a higher percentage of correct doses taken (p=0.02), percentage number of doses taken (p=0.01), and percentage of prescribed doses taken on schedule (p=0.01). TM response rates were higher for antiplatelets than statins (p=0.005). Self-reported adherence revealed no significant differences among groups. CONCLUSION: TM increased adherence to antiplatelet therapy demonstrated by MEMS and TM responses. PRACTICE IMPLICATIONS: Feasibility and high satisfaction were established. Mobile health interventions show promise in promoting medication adherence. Published by Elsevier Ireland Ltd.
RCT Entities:
OBJECTIVE: Pharmacologic treatment for secondary prevention of coronary heart disease (CHD) is critical to prevent adverse clinical outcomes. In a randomized controlled trial, we compared antiplatelet and statin adherence among patients with CHD who received: (1) text messages (TM) for medication reminders and education, (2) educational TM only, or (3) No TM. METHODS: A mobile health intervention delivered customized TM for 30 days. We assessed and analyzed medication adherence with electronic monitoring devices [Medication Event Monitoring System (MEMS)] by one-way ANOVA and Welch tests, two-way TM response rates by t-tests, and self-reported adherence (Morisky Medication Adherence Scale) by Repeated Measures ANOVA. RESULTS: Among 90 patients (76% male, mean age 59.2 years), MEMS revealed patients who received TM for antiplatelets had a higher percentage of correct doses taken (p=0.02), percentage number of doses taken (p=0.01), and percentage of prescribed doses taken on schedule (p=0.01). TM response rates were higher for antiplatelets than statins (p=0.005). Self-reported adherence revealed no significant differences among groups. CONCLUSION: TM increased adherence to antiplatelet therapy demonstrated by MEMS and TM responses. PRACTICE IMPLICATIONS: Feasibility and high satisfaction were established. Mobile health interventions show promise in promoting medication adherence. Published by Elsevier Ireland Ltd.
Entities:
Keywords:
Antiplatelets; Coronary heart disease; Medication adherence; Mobile phone; Statins; Text messaging
Authors: Alan Sosa; Nathan Heineman; Kimberly Thomas; Kai Tang; Marie Feinstein; Michelle Y Martin; Baran Sumer; David L Schwartz Journal: Head Neck Date: 2017-03-06 Impact factor: 3.147
Authors: G R Kruse; E Park; J E Haberer; L Abroms; N N Shahid; S E Howard; Y Chang; J S Haas; N A Rigotti Journal: Contemp Clin Trials Date: 2019-03-25 Impact factor: 2.226