Literature DB >> 24320053

Role of 53BP1 in the regulation of DNA double-strand break repair pathway choice.

Arun Gupta1, Clayton R Hunt, Sharmistha Chakraborty, Raj K Pandita, John Yordy, Deepti B Ramnarain, Nobuo Horikoshi, Tej K Pandita.   

Abstract

The p53-binding protein 1 (53BP1) is a well-known DNA damage response (DDR) factor, which is recruited to nuclear structures at the site of DNA damage and forms readily visualized ionizing radiation (IR) induced foci. Depletion of 53BP1 results in cell cycle arrest in G2/M phase as well as genomic instability in human as well as mouse cells. Within the DNA damage response mechanism, 53BP1 is classified as an adaptor/mediator, required for processing of the DNA damage response signal and as a platform for recruitment of other repair factors. More recently, specific 53BP1 contributions to DSB repair pathway choice have been recognized and are being characterized. In this review, we have summarized recent advances in understanding the role of 53BP1 in regulating DNA DSBs repair pathway choice, variable diversity joining [V(D)J] recombination and class-switch recombination (CSR).

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Year:  2013        PMID： 24320053      PMCID： PMC4133096          DOI： 10.1667/RR13572.1

Source DB:  PubMed          Journal:  Radiat Res        ISSN： 0033-7587            Impact factor:   2.841


  98 in total

1.  Functional redundancy between repair factor XLF and damage response mediator 53BP1 in V(D)J recombination and DNA repair.

Authors:  Valentyn Oksenych; Frederick W Alt; Vipul Kumar; Bjoern Schwer; Duane R Wesemann; Erica Hansen; Harin Patel; Arthur Su; Chunguang Guo
Journal:  Proc Natl Acad Sci U S A       Date:  2012-01-30       Impact factor: 11.205

2.  BRCA1 deficient embryonic stem cells display a decreased homologous recombination frequency and an increased frequency of non-homologous recombination that is corrected by expression of a brca1 transgene.

Authors:  J N Snouwaert; L C Gowen; A M Latour; A R Mohn; A Xiao; L DiBiase; B H Koller
Journal:  Oncogene       Date:  1999-12-20       Impact factor: 9.867

3.  MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks.

Authors:  Manuel Stucki; Julie A Clapperton; Duaa Mohammad; Michael B Yaffe; Stephen J Smerdon; Stephen P Jackson
Journal:  Cell       Date:  2005-12-29       Impact factor: 41.582

Review 4.  Homologous repair of DNA damage and tumorigenesis: the BRCA connection.

Authors:  Maria Jasin
Journal:  Oncogene       Date:  2002-12-16       Impact factor: 9.867

5.  Nonhomologous end joining and V(D)J recombination require an additional factor.

Authors:  Y Dai; B Kysela; L A Hanakahi; K Manolis; E Riballo; M Stumm; T O Harville; S C West; M A Oettinger; P A Jeggo
Journal:  Proc Natl Acad Sci U S A       Date:  2003-02-25       Impact factor: 11.205

Review 6.  Histone modifications and DNA double-strand break repair after exposure to ionizing radiations.

Authors:  Clayton R Hunt; Deepti Ramnarain; Nobuo Horikoshi; Puneeth Iyengar; Raj K Pandita; Jerry W Shay; Tej K Pandita
Journal:  Radiat Res       Date:  2013-02-01       Impact factor: 2.841

7.  Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint.

Authors:  Joshua Silverman; Hiroyuki Takai; Sara B C Buonomo; Frank Eisenhaber; Titia de Lange
Journal:  Genes Dev       Date:  2004-09-01       Impact factor: 11.361

8.  Two cellular proteins that bind to wild-type but not mutant p53.

Authors:  K Iwabuchi; P L Bartel; B Li; R Marraccino; S Fields
Journal:  Proc Natl Acad Sci U S A       Date:  1994-06-21       Impact factor: 11.205

9.  53BP1 is required for class switch recombination.

Authors:  Irene M Ward; Bernardo Reina-San-Martin; Alexandru Olaru; Kay Minn; Koji Tamada; Julie S Lau; Marilia Cascalho; Lieping Chen; Andre Nussenzweig; Ferenc Livak; Michel C Nussenzweig; Junjie Chen
Journal:  J Cell Biol       Date:  2004-05-24       Impact factor: 10.539

10.  53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark.

Authors:  Amélie Fradet-Turcotte; Marella D Canny; Cristina Escribano-Díaz; Alexandre Orthwein; Charles C Y Leung; Hao Huang; Marie-Claude Landry; Julianne Kitevski-LeBlanc; Sylvie M Noordermeer; Frank Sicheri; Daniel Durocher
Journal:  Nature       Date:  2013-06-12       Impact factor: 49.962
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  42 in total

1.  Femtosecond near-infrared laser microirradiation reveals a crucial role for PARP signaling on factor assemblies at DNA damage sites.

Authors:  Gladys Mae Saquilabon Cruz; Xiangduo Kong; Bárbara Alcaraz Silva; Nima Khatibzadeh; Ryan Thai; Michael W Berns; Kyoko Yokomori
Journal:  Nucleic Acids Res       Date:  2015-09-30       Impact factor: 16.971

2.  Role of the Exocyst Complex Component Sec6/8 in Genomic Stability.

Authors:  Michael J Torres; Raj K Pandita; Ozlem Kulak; Rakesh Kumar; Etienne Formstecher; Nobuo Horikoshi; Kalpana Mujoo; Clayton R Hunt; Yingming Zhao; Lawrence Lum; Aubhishek Zaman; Charles Yeaman; Michael A White; Tej K Pandita
Journal:  Mol Cell Biol       Date:  2015-08-17       Impact factor: 4.272

3.  MOF phosphorylation by ATM regulates 53BP1-mediated double-strand break repair pathway choice.

Authors:  Arun Gupta; Clayton R Hunt; Muralidhar L Hegde; Sharmistha Chakraborty; Sharmistha Chakraborty; Durga Udayakumar; Nobuo Horikoshi; Mayank Singh; Deepti B Ramnarain; Walter N Hittelman; Sarita Namjoshi; Aroumougame Asaithamby; Tapas K Hazra; Thomas Ludwig; Raj K Pandita; Jessica K Tyler; Tej K Pandita
Journal:  Cell Rep       Date:  2014-06-19       Impact factor: 9.423

4.  Detecting ATM-dependent chromatin modification in DNA damage response.

Authors:  Durga Udayakumar; Nobuo Horikoshi; Lopa Mishra; Clayton Hunt; Tej K Pandita
Journal:  Methods Mol Biol       Date:  2015

5.  β1-Integrin Impacts Rad51 Stability and DNA Double-Strand Break Repair by Homologous Recombination.

Authors:  Kazi Mokim Ahmed; Raj K Pandita; Dharmendra Kumar Singh; Clayton R Hunt; Tej K Pandita
Journal:  Mol Cell Biol       Date:  2018-04-16       Impact factor: 4.272

6.  A Perspective on Chromosomal Double Strand Break Markers in Mammalian Cells.

Authors:  Haibo Wang; Sanjay Adhikari; Brian E Butler; Tej K Pandita; Sankar Mitra; Muralidhar L Hegde
Journal:  Jacobs J Radiat Oncol       Date:  2014

7.  Microtubule-targeting agents augment the toxicity of DNA-damaging agents by disrupting intracellular trafficking of DNA repair proteins.

Authors:  Marianne S Poruchynsky; Edina Komlodi-Pasztor; Shana Trostel; Julia Wilkerson; Marie Regairaz; Yves Pommier; Xu Zhang; Tapan Kumar Maity; Robert Robey; Mauricio Burotto; Dan Sackett; Udayan Guha; Antonio Tito Fojo
Journal:  Proc Natl Acad Sci U S A       Date:  2015-01-20       Impact factor: 11.205

8.  Modulation of BRCA1 mediated DNA damage repair by deregulated ER-α signaling in breast cancers.

Authors:  Arathi Rajan; Geetu R Varghese; Induprabha Yadev; Jaimie Anandan; Neetha R Latha; Dipyaman Patra; Neethu Krishnan; Krithiga Kuppusamy; Arathy V Warrier; Satej Bhushan; Revathy Nadhan; Ram Mohan Ram Kumar; Priya Srinivas
Journal:  Am J Cancer Res       Date:  2022-01-15       Impact factor: 6.166

Review 9.  A multifaceted role for MOF histone modifying factor in genome maintenance.

Authors:  Kalpana Mujoo; Clayton R Hunt; Nobuo Horikoshi; Tej K Pandita
Journal:  Mech Ageing Dev       Date:  2016-03-30       Impact factor: 5.432

10.  The Ubiquitin E3/E4 Ligase UBE4A Adjusts Protein Ubiquitylation and Accumulation at Sites of DNA Damage, Facilitating Double-Strand Break Repair.

Authors:  Keren Baranes-Bachar; Adva Levy-Barda; Judith Oehler; Dylan A Reid; Isabel Soria-Bretones; Ty C Voss; Dudley Chung; Yoon Park; Chao Liu; Jong-Bok Yoon; Wei Li; Graham Dellaire; Tom Misteli; Pablo Huertas; Eli Rothenberg; Kristijan Ramadan; Yael Ziv; Yosef Shiloh
Journal:  Mol Cell       Date:  2018-03-01       Impact factor: 17.970
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