Literature DB >> 24316532

FTIR spectroscopic comparison of serum from lung cancer patients and healthy persons.

Xin Wang1, Xiang Shen2, Daping Sheng3, Xianliang Chen1, Xingcun Liu4.   

Abstract

The incidence and mortality of lung cancer remains so high that it is very urgent to develop an effective method for early detection of lung cancer. Serum can reflect physiological and pathological changes of human body, so FTIR spectroscopy was used to compare lung cancer patients' and healthy persons' serum in this study. The A1080/A1170 ratio might be potentially useful for distinguishing lung cancer patients' serum from healthy persons' serum. Moreover, the result of curve fitting indicated that the ratios of α-helix/antiparallel β-sheet were lower for lung cancer patients' serum than those for healthy persons' serum. These results indicated that IR spectra of serum might be potentially useful for detecting lung cancer.
Copyright © 2013 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Curve fitting; FTIR spectroscopy; Healthy persons; Lung cancer; Serum

Mesh：

Year:  2013        PMID： 24316532     DOI： 10.1016/j.saa.2013.11.049

Source DB:  PubMed          Journal:  Spectrochim Acta A Mol Biomol Spectrosc        ISSN： 1386-1425            Impact factor:   4.098


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  9 in total

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