Literature DB >> 24311868

Study on optimisation of extraction process of tanshinone IIA and its mechanism of induction of gastric cancer SGC7901 cell apoptosis.

Jianhong Hou1, Jiantai He, Xin Jin, Tian Hu, Yangde Zhang.   

Abstract

The objective of this paper was to investigate the extraction process of tanshinone IIA and its mechanism of induction of gastric cancer SGC7901 cell apoptosis. Extraction process of tanshinone IIA was optimised by orthogonal experimental method, and its effect on gastric cancer SGC7901 cell apoptosis was observed using MTT assay and electron microscopy. The optimum extraction process of tanshinone IIA was as follows: addition of a 10-fold amount of 80% ethanol, one-time extraction, and extraction time of 45 minutes. The study concluded that tanshinone IIA can induce apoptosis of gastric cancer SGC7901 cells.

Entities:  

Keywords:  MTT assay; Tanshinone IIA; gastric cancer SGC7901 cells

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Year:  2013        PMID： 24311868      PMCID： PMC3847383          DOI： 10.4314/ajtcam.v10i6.10

Source DB:  PubMed          Journal:  Afr J Tradit Complement Altern Med        ISSN： 2505-0044


  6 in total

1.  Synthesis of novel chemical probes for the study of tanshinone binding proteins.

Authors:  Jin-Soo Lee; Sun-Young Han; Myong Sang Kim; Chan-Mo Yu; Myung Hee Kim; Seong Hwan Kim; Yong Ki Min; Bum Tae Kim
Journal:  Bioorg Med Chem Lett       Date:  2006-07-25       Impact factor: 2.823

2.  Peg3/Pw1 promotes p53-mediated apoptosis by inducing Bax translocation from cytosol to mitochondria.

Authors:  Y Deng; X Wu
Journal:  Proc Natl Acad Sci U S A       Date:  2000-10-24       Impact factor: 11.205

3.  Induction of apoptosis and inhibition of cell adhesive and invasive effects by tanshinone IIA in acute promyelocytic leukemia cells in vitro.

Authors:  Jia-Jun Liu; Dong-Jun Lin; Pei-Qing Liu; Min Huang; Xu-Dong Li; Ren-Wei Huang
Journal:  J Biomed Sci       Date:  2006-09-06       Impact factor: 8.410

4.  [The growth-inhibiting effect and its molecular mechanism of Tanshinone on human lung cancer cell line in vitro].

Authors:  Jintao He; Qinghua Zhou; Shulan Yuan; Yanping Wang; Xiaohe Chen; Jianjun Qin
Journal:  Zhongguo Fei Ai Za Zhi       Date:  2002-04-20

5.  [Complete remission of acute promyelocytic leukemia resisting all-trans retinoic acid of one case treated by tanshinone II A].

Authors:  Yi-Ming Yang; Ting Liu
Journal:  Sichuan Da Xue Xue Bao Yi Xue Ban       Date:  2006-11

6.  Inhibition of Mitochondrial Permeability Transition Pore: A Possible Mechanism for Cardioprotection Conferred by Pretreatment with Tanshinone IIA.

Authors:  Shi-Zhong Zhang; Zhi-Guo Ye; Qiang Xia; Wei Zhang; Iain Bruce
Journal:  Conf Proc IEEE Eng Med Biol Soc       Date:  2005
  6 in total
  1 in total

1.  Influence of Tanshinone IIA on apoptosis of human esophageal carcinoma Eca-109 cells and its molecular mechanism.

Authors:  Yan Zhang; Shan Li; Hang He; Qianqian Han; Baiyan Wang; Yanqin Zhu
Journal:  Thorac Cancer       Date:  2017-04-13       Impact factor: 3.500
  1 in total

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