| Literature DB >> 16872829 |
Jin-Soo Lee1, Sun-Young Han, Myong Sang Kim, Chan-Mo Yu, Myung Hee Kim, Seong Hwan Kim, Yong Ki Min, Bum Tae Kim.
Abstract
Novel diazirine or biotin-labeled tanshinone probes were synthesized and evaluated for TRAP inhibitory activity against RANKL-induced osteoclastogenesis in RAW264.7 cells. We found that diazirine-labeled derivatives (18 and 20) are potent inhibitors of RANKL-induced osteoclastogenesis. IC50 values were 18.02 and 15.00 microM, respectively. These probes will be useful reagents for investigating tanshinone-proteins interactions.Entities:
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Year: 2006 PMID： 16872829 DOI： 10.1016/j.bmcl.2006.07.019
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823