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Literature DB >> 24311119

Metastasis suppressors in breast cancers: mechanistic insights and clinical potential.

Christopher R Bohl¹, Sitaram Harihar¹, Warren L Denning¹, Rahul Sharma¹, Danny R Welch¹.

Abstract

For the most part, normal epithelial cells do not disseminate to other parts of the body and proliferate, as do metastatic cells. Presumably, a class of molecules-termed metastasis suppressors-are involved in this homeostatic control. Metastasis suppressors are, by definition, cellular factors that, when re-expressed in metastatic cells, functionally inhibit metastasis without significantly inhibiting tumor growth. In this brief review, we catalog known metastasis suppressors, what is known about their mechanism(s) of action, and experimental and clinical associations to date.

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Year: 2013 PMID： 24311119 PMCID： PMC3923422 DOI： 10.1007/s00109-013-1109-y

Source DB: PubMed Journal: J Mol Med (Berl) ISSN： 0946-2716 Impact factor: 4.599

122 in total

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Authors: Jeanne M V Louderbough; Joyce A Schroeder
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2. Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role.

Authors: K Vleminckx; L Vakaet; M Mareel; W Fiers; F van Roy
Journal: Cell Date: 1991-07-12 Impact factor: 41.582

3. Suppression of metastatic colonization by the context-dependent activation of the c-Jun NH2-terminal kinase kinases JNKK1/MKK4 and MKK7.

Authors: Donald J Vander Griend; Masha Kocherginsky; Jonathan A Hickson; Walter M Stadler; Anning Lin; Carrie W Rinker-Schaeffer
Journal: Cancer Res Date: 2005-12-01 Impact factor: 12.701

4. Altered expression of NM23, a gene associated with low tumor metastatic potential, during adenovirus 2 Ela inhibition of experimental metastasis.

Authors: P S Steeg; G Bevilacqua; R Pozzatti; L A Liotta; M E Sobel
Journal: Cancer Res Date: 1988-11-15 Impact factor: 12.701

5. Prognostic significance of NDRG1 expression in oral and oropharyngeal squamous cell carcinoma.

Authors: Marcelo Dos Santos; Ana Maria da Cunha Mercante; Fábio Daumas Nunes; Andréia Machado Leopoldino; Marcos Brasilino de Carvalho; Diana Gazito; Rossana Verónica Mendoza López; Paula Blandina Olga Chiappini; Paulo Bentes de Carvalho Neto; Erica Erina Fukuyama; Eloiza Helena Tajara; Iúri Drumond Louro; Adriana Madeira Álvares da Silva
Journal: Mol Biol Rep Date: 2012-09-13 Impact factor: 2.316

6. SSeCKS metastasis-suppressing activity in MatLyLu prostate cancer cells correlates with vascular endothelial growth factor inhibition.

Authors: Bing Su; Qiao Zheng; Mary M Vaughan; Yahao Bu; Irwin H Gelman
Journal: Cancer Res Date: 2006-06-01 Impact factor: 12.701

7. Delineation of the centromeric and telomeric chromosome segment 11p15.5 lung cancer suppressor regions LOH11A and LOH11B.

Authors: K C O'Briant; G Bepler
Journal: Genes Chromosomes Cancer Date: 1997-02 Impact factor: 5.006

8. A shift from nuclear to cytoplasmic breast cancer metastasis suppressor 1 expression is associated with highly proliferative estrogen receptor-negative breast cancers.

Authors: Natalya Frolova; Mick D Edmonds; Thomas M Bodenstine; Robert Seitz; Martin R Johnson; Rui Feng; Danny R Welch; Andra R Frost
Journal: Tumour Biol Date: 2009-07-16

Review 9. The histone LSD1 demethylase in stemness and cancer transcription programs.

Authors: Stefano Amente; Luigi Lania; Barbara Majello
Journal: Biochim Biophys Acta Date: 2013-05-16

10. Low RKIP expression associates with poor prognosis in bladder cancer patients.

Authors: Julieta Afonso; Adhemar Longatto-Filho; Olga Martinho; Francisco Lobo; Teresina Amaro; Rui M Reis; Lúcio L Santos
Journal: Virchows Arch Date: 2013-03-06 Impact factor: 4.064

22 in total

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Authors: Carolyn M Klinge
Journal: J Bioenerg Biomembr Date: 2017-08 Impact factor: 2.945

Review 2. Regulation of breast cancer metastasis signaling by miRNAs.

Authors: Belinda J Petri; Carolyn M Klinge
Journal: Cancer Metastasis Rev Date: 2020-09 Impact factor: 9.264

3. Expression of LC3B and FIP200/Atg17 in brain metastases of breast cancer.

Authors: Nooshin Hashemi-Sadraei; Gaëlle M Müller-Greven; Fadi W Abdul-Karim; Ilya Ulasov; Erinn Downs-Kelly; Monica E Burgett; Adam Lauko; Maha A Qadan; Robert J Weil; Manmeet S Ahluwalia; Lingling Du; Richard A Prayson; Samuel T Chao; Thomas G Budd; Jill Barnholtz-Sloan; Amy S Nowacki; Ruth A Keri; Candece L Gladson
Journal: J Neurooncol Date: 2018-08-09 Impact factor: 4.130

4. MiR-148a inhibits the proliferation and migration of glioblastoma by targeting ITGA9.

Authors: Tong-Jiang Xu; Peng Qiu; Yu-Bao Zhang; Sheng-Yuan Yu; Guang-Ming Xu; Wei Yang
Journal: Hum Cell Date: 2019-09-05 Impact factor: 4.174

5. Race Disparities in the Contribution of miRNA Isoforms and tRNA-Derived Fragments to Triple-Negative Breast Cancer.

Authors: Aristeidis G Telonis; Isidore Rigoutsos
Journal: Cancer Res Date: 2017-12-11 Impact factor: 12.701

6. Genome-wide in vivo RNAi screen identifies ITIH5 as a metastasis suppressor in pancreatic cancer.

Authors: Ken Sasaki; Hiroshi Kurahara; Eric D Young; Shoji Natsugoe; Asami Ijichi; Tomoo Iwakuma; Danny R Welch
Journal: Clin Exp Metastasis Date: 2017-03-13 Impact factor: 5.150

7. Hypoxia-inducible factor-dependent signaling between triple-negative breast cancer cells and mesenchymal stem cells promotes macrophage recruitment.

Authors: Pallavi Chaturvedi; Daniele M Gilkes; Naoharu Takano; Gregg L Semenza
Journal: Proc Natl Acad Sci U S A Date: 2014-05-05 Impact factor: 11.205