Literature DB >> 23684752

The histone LSD1 demethylase in stemness and cancer transcription programs.

Stefano Amente1, Luigi Lania, Barbara Majello.   

Abstract

DNA and histone chromatin modifying enzymes play a crucial role in chromatin remodeling in several biological processes. Lysine-specific demethylase 1 (LSD1), the first identified histone demethylase, is a relevant player in the regulation of a broad spectrum of biological processes including development, cellular differentiation, embryonic pluripotency and cancer. Here, we review recent insights on the role of LSD1 activity in chromatin regulatory complexes, its functional role in the epigenetic changes during embryonic development, in the establishment and maintenance of stemness and during cancer progression.
Copyright © 2013 The Authors. Published by Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Cancer; Chromatin; Histone modification; LSD1; Stem cell

Mesh：

Substances：

Year:  2013        PMID： 23684752     DOI： 10.1016/j.bbagrm.2013.05.002

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  82 in total

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2.  CBB1003, a lysine-specific demethylase 1 inhibitor, suppresses colorectal cancer cells growth through down-regulation of leucine-rich repeat-containing G-protein-coupled receptor 5 expression.

Authors:  Hung-Chih Hsu; Yi-Shiuan Liu; Kai-Chi Tseng; Tsai-Sheng Yang; Chien-Yuh Yeh; Jeng-Fu You; Hsin-Yuan Hung; Shu-Jen Chen; Hua-Chien Chen
Journal:  J Cancer Res Clin Oncol       Date:  2014-07-25       Impact factor: 4.553

Review 3.  KDM1 class flavin-dependent protein lysine demethylases.

Authors:  Jonathan M Burg; Jennifer E Link; Brittany S Morgan; Frederick J Heller; Amanda E Hargrove; Dewey G McCafferty
Journal:  Biopolymers       Date:  2015-07       Impact factor: 2.505

4.  Androgen and AR contribute to breast cancer development and metastasis: an insight of mechanisms.

Authors:  J Feng; L Li; N Zhang; J Liu; L Zhang; H Gao; G Wang; Y Li; Y Zhang; X Li; D Liu; J Lu; B Huang
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5.  Novel KDM1A inhibitors induce differentiation and apoptosis of glioma stem cells via unfolded protein response pathway.

Authors:  G R Sareddy; S Viswanadhapalli; P Surapaneni; T Suzuki; A Brenner; R K Vadlamudi
Journal:  Oncogene       Date:  2016-11-28       Impact factor: 9.867

6.  Orthotopic non-metastatic and metastatic oral cancer mouse models.

Authors:  Manish V Bais; Maria Kukuruzinska; Philip C Trackman
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7.  The LSD1 Family of Histone Demethylases and the Pumilio Posttranscriptional Repressor Function in a Complex Regulatory Feedback Loop.

Authors:  Wayne O Miles; Julie M J Lepesant; Jessie Bourdeaux; Manuela Texier; Marc A Kerenyi; Makoto Nakakido; Ryuji Hamamoto; Stuart H Orkin; Nicholas J Dyson; Luisa Di Stefano
Journal:  Mol Cell Biol       Date:  2015-10-05       Impact factor: 4.272

8.  Regulation of hypoxia responses by flavin adenine dinucleotide-dependent modulation of HIF-1α protein stability.

Authors:  Suk-Jin Yang; Young Soo Park; Jung Hee Cho; Byul Moon; Hyun-Jung An; Ju Yeon Lee; Zhi Xie; Yuli Wang; David Pocalyko; Dong Chul Lee; Hyun Ahm Sohn; Minho Kang; Jin Young Kim; Eunhee Kim; Kyung Chan Park; Jung-Ae Kim; Young Il Yeom
Journal:  EMBO J       Date:  2017-03-09       Impact factor: 11.598

Review 9.  Metastasis suppressors in breast cancers: mechanistic insights and clinical potential.

Authors:  Christopher R Bohl; Sitaram Harihar; Warren L Denning; Rahul Sharma; Danny R Welch
Journal:  J Mol Med (Berl)       Date:  2013-12-06       Impact factor: 4.599

10.  GATA2 regulates GATA1 expression through LSD1-mediated histone modification.

Authors:  Yidi Guo; Xueqi Fu; Bo Huo; Yongsen Wang; Jing Sun; Lingyuan Meng; Tian Hao; Zhizhuang Joe Zhao; Xin Hu
Journal:  Am J Transl Res       Date:  2016-05-15       Impact factor: 4.060
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