R Mehta1, A Petrova1. 1. Department of Pediatrics, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USA.
Abstract
OBJECTIVE: As the antioxidant properties of human milk may be beneficial for very preterm-born infants, it is important to identify the association between total antioxidant capacity (TAC) and bio-active proteins. STUDY DESIGN: Breast milk was prospectively collected (four times) on postpartum days 6 to 8, 13 to 15, 20 to 22 and 27 to 29 from 15 mothers who had delivered between 24 and 31 weeks of gestation. Skimmed milk was assayed to measure TAC and bio-active proteins (lysozyme, lactoferrin, leptin and adiponectin). The association between TAC and levels of bio-active proteins during the first month of lactation was analyzed in a regression model. RESULT: Coefficient of determinations (R(2)) revealed an overall effect of bio-active proteins on breast milk TAC (R(2)=0.635+/-0.102, P<0.0001). Breast milk leptin, lysozyme and lactoferrin levels were identified as independent factors that significantly predict the concentration of TAC. CONCLUSION: The identified enhancement of the antioxidant capacity of human milk by bio-active proteins that are lacking in commercial formula supports consideration of breast milk as ideal nutrition for preterm-born neonates.
OBJECTIVE: As the antioxidant properties of human milk may be beneficial for very preterm-born infants, it is important to identify the association between total antioxidant capacity (TAC) and bio-active proteins. STUDY DESIGN: Breast milk was prospectively collected (four times) on postpartum days 6 to 8, 13 to 15, 20 to 22 and 27 to 29 from 15 mothers who had delivered between 24 and 31 weeks of gestation. Skimmed milk was assayed to measure TAC and bio-active proteins (lysozyme, lactoferrin, leptin and adiponectin). The association between TAC and levels of bio-active proteins during the first month of lactation was analyzed in a regression model. RESULT: Coefficient of determinations (R(2)) revealed an overall effect of bio-active proteins on breast milk TAC (R(2)=0.635+/-0.102, P<0.0001). Breast milk leptin, lysozyme and lactoferrin levels were identified as independent factors that significantly predict the concentration of TAC. CONCLUSION: The identified enhancement of the antioxidant capacity of human milk by bio-active proteins that are lacking in commercial formula supports consideration of breast milk as ideal nutrition for preterm-born neonates.
Authors: Dominick J Lemas; Bridget E Young; Peter R Baker; Angela C Tomczik; Taylor K Soderborg; Teri L Hernandez; Becky A de la Houssaye; Charles E Robertson; Michael C Rudolph; Diana Ir; Zachary W Patinkin; Nancy F Krebs; Stephanie A Santorico; Tiffany Weir; Linda A Barbour; Daniel N Frank; Jacob E Friedman Journal: Am J Clin Nutr Date: 2016-05 Impact factor: 7.045
Authors: Andrea Gila-Diaz; Silvia M Arribas; Alba Algara; María A Martín-Cabrejas; Ángel Luis López de Pablo; Miguel Sáenz de Pipaón; David Ramiro-Cortijo Journal: Nutrients Date: 2019-06-10 Impact factor: 5.717