BACKGROUND: Near-infrared spectroscopy (NIRS) is a non-invasive technique designed to study regional oxygenation (rSO(2)) by measuring the absorption of chromophores. This study investigated the role of NIRS in the real-time monitoring of kidney graft perfusion for 72 h post-transplantation. METHODS: Consecutive children undergoing living related donor (LRD) or deceased donor (DD) kidney transplantation (KTP) were prospectively enrolled between April 2010 and August 2011. Renal rSO(2) values were registered continuously for 3 days and correlated with hourly urine output, serum creatinine, and urinary neutrophil gelatinase-associated lipocalin (u-NGAL). RESULTS: Twenty-four children were included, 6 underwent LRD and 18 DD KTP. Median age was 12.5 years (interquartile range [IQR] 3.5-16.6) and median body weight was 37 kg (IQR 13-49.7). Four patients experienced delayed graft function (DGF). Renal Doppler ultrasound showed normal vascularization patterns in all children. Median basal renal rSO(2) value was 68.8 % (IQR 59.3-76.2), significantly lower than the end-of-period result (83.6 %; IQR 79.2-90.4; p < 0.0001). Renal rSO(2) values showed significant correlation with serum creatinine (rs = -0.62; p < 0.05) and estimated glomerular filtration rate (eGFR) (rs = 0.64; p < 0.05). No correlation was shown between rSO(2) and diuresis. Increased rSO(2) was also found in patients who experienced DGF. u-NGAL exhibited a trend toward a decrease from baseline in both DD and LRD KTPs, with a strong negative correlation with rSO(2). CONCLUSIONS: rSO(2) assessed by NIRS strongly correlates with common markers of kidney graft function and perfusion, allowing continuous real-time monitoring of blood flow in renal grafts.
BACKGROUND: Near-infrared spectroscopy (NIRS) is a non-invasive technique designed to study regional oxygenation (rSO(2)) by measuring the absorption of chromophores. This study investigated the role of NIRS in the real-time monitoring of kidney graft perfusion for 72 h post-transplantation. METHODS: Consecutive children undergoing living related donor (LRD) or deceased donor (DD) kidney transplantation (KTP) were prospectively enrolled between April 2010 and August 2011. Renal rSO(2) values were registered continuously for 3 days and correlated with hourly urine output, serum creatinine, and urinary neutrophil gelatinase-associated lipocalin (u-NGAL). RESULTS: Twenty-four children were included, 6 underwent LRD and 18 DD KTP. Median age was 12.5 years (interquartile range [IQR] 3.5-16.6) and median body weight was 37 kg (IQR 13-49.7). Four patients experienced delayed graft function (DGF). Renal Doppler ultrasound showed normal vascularization patterns in all children. Median basal renal rSO(2) value was 68.8 % (IQR 59.3-76.2), significantly lower than the end-of-period result (83.6 %; IQR 79.2-90.4; p < 0.0001). Renal rSO(2) values showed significant correlation with serum creatinine (rs = -0.62; p < 0.05) and estimated glomerular filtration rate (eGFR) (rs = 0.64; p < 0.05). No correlation was shown between rSO(2) and diuresis. Increased rSO(2) was also found in patients who experienced DGF. u-NGAL exhibited a trend toward a decrease from baseline in both DD and LRD KTPs, with a strong negative correlation with rSO(2). CONCLUSIONS:rSO(2) assessed by NIRS strongly correlates with common markers of kidney graft function and perfusion, allowing continuous real-time monitoring of blood flow in renal grafts.
Authors: Thomas Bessede; Stephane Droupy; Yacine Hammoudi; Dina Bedretdinova; Antoine Durrbach; Bernard Charpentier; Gerard Benoit Journal: Transpl Int Date: 2012-07-21 Impact factor: 3.782
Authors: C R Parikh; A Jani; J Mishra; Q Ma; C Kelly; J Barasch; C L Edelstein; P Devarajan Journal: Am J Transplant Date: 2006-07 Impact factor: 8.086
Authors: George M Hoffman; Eckehard A Stuth; Robert D Jaquiss; Patrick L Vanderwal; Susan R Staudt; Todd J Troshynski; Nancy S Ghanayem; James S Tweddell Journal: J Thorac Cardiovasc Surg Date: 2004-01 Impact factor: 5.209
Authors: M Sabbatini; G Sansone; F Uccello; L De Nicola; A Giliberti; V Sepe; P Margri; G Conte; V E Andreucci Journal: Kidney Int Date: 1994-05 Impact factor: 10.612
Authors: Barbara Sinner; Miriam Banas; Clara Brunete-Lorenzo; Robert Zant; Birgit Knoppke; Marcus N Scherer; Bernhard M Graf; Dirk Lunz Journal: Ann Transplant Date: 2020-01-28 Impact factor: 1.530