Literature DB >> 24298330

Tgf-Beta family signaling in embryonic stem cells.

Kyung-Soon Park1.   

Abstract

Ligands of transforming growth factor beta (TGF-β) family members have been implicated in the development and patho-physiological process of various organs. Embryonic stem cells (ESCs) are characterized by their ability to proliferate indefinitely and differentiated into all three germ layer cells, which are termed as pluripotency and self-renewal,respectively. For successful therapeutic application of ESCs, it is essential to understand the mechanisms underlying self-renewal and pluripotency, which involve complex networks among key factors including transcription factors, epigenetic control, microRNAs and signaling pathways. In this review, we discuss recent progress on the function of TGF beta family ligands and their canonical SMAD signaling in the maintenance of ESC' s identity.

Entities:  

Keywords:  Activin; Embryonic stem cell; Lefty; Nodal; Pluripotency; Reprogramming; TGF-beta

Year:  2011        PMID： 24298330      PMCID： PMC3840975          DOI： 10.15283/ijsc.2011.4.1.18

Source DB:  PubMed          Journal:  Int J Stem Cells        ISSN： 2005-3606            Impact factor:   2.500


  41 in total

Review 1.  Mechanisms of TGF-beta signaling from cell membrane to the nucleus.

Authors:  Yigong Shi; Joan Massagué
Journal:  Cell       Date:  2003-06-13       Impact factor: 41.582

2.  Differentiation plasticity regulated by TGF-beta family proteins in development and disease.

Authors:  Rik Derynck; Rosemary J Akhurst
Journal:  Nat Cell Biol       Date:  2007-09       Impact factor: 28.824

3.  Distinct transcriptional regulatory mechanisms underlie left-right asymmetric expression of lefty-1 and lefty-2.

Authors:  Y Saijoh; H Adachi; K Mochida; S Ohishi; A Hirao; H Hamada
Journal:  Genes Dev       Date:  1999-02-01       Impact factor: 11.361

Review 4.  Embryo-derived stem cells: of mice and men.

Authors:  A G Smith
Journal:  Annu Rev Cell Dev Biol       Date:  2001       Impact factor: 13.827

5.  Left-right asymmetric expression of lefty2 and nodal is induced by a signaling pathway that includes the transcription factor FAST2.

Authors:  Y Saijoh; H Adachi; R Sakuma; C Y Yeo; K Yashiro; M Watanabe; H Hashiguchi; K Mochida; S Ohishi; M Kawabata; K Miyazono; M Whitman; H Hamada
Journal:  Mol Cell       Date:  2000-01       Impact factor: 17.970

6.  Activin A maintains self-renewal and regulates fibroblast growth factor, Wnt, and bone morphogenic protein pathways in human embryonic stem cells.

Authors:  Lei Xiao; Xuan Yuan; Saul J Sharkis
Journal:  Stem Cells       Date:  2006-02-02       Impact factor: 6.277

7.  Distinct transcriptional regulation and phylogenetic divergence of human LEFTY genes.

Authors:  K Yashiro; Y Saijoh; R Sakuma; M Tada; N Tomita; K Amano; Y Matsuda; M Monden; S Okada; H Hamada
Journal:  Genes Cells       Date:  2000-05       Impact factor: 1.891

8.  Tgfbeta signal inhibition cooperates in the induction of iPSCs and replaces Sox2 and cMyc.

Authors:  Nimet Maherali; Konrad Hochedlinger
Journal:  Curr Biol       Date:  2009-09-17       Impact factor: 10.834

9.  Induction of epidermis and inhibition of neural fate by Bmp-4.

Authors:  P A Wilson; A Hemmati-Brivanlou
Journal:  Nature       Date:  1995-07-27       Impact factor: 49.962

10.  A primary requirement for nodal in the formation and maintenance of the primitive streak in the mouse.

Authors:  F L Conlon; K M Lyons; N Takaesu; K S Barth; A Kispert; B Herrmann; E J Robertson
Journal:  Development       Date:  1994-07       Impact factor: 6.868
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  13 in total

1.  Fam60a defines a variant Sin3a-Hdac complex in embryonic stem cells required for self-renewal.

Authors:  Gundula Streubel; Darren J Fitzpatrick; Giorgio Oliviero; Andrea Scelfo; Bruce Moran; Sudipto Das; Nayla Munawar; Ariane Watson; Kieran Wynne; Gian Luca Negri; Eugene T Dillon; SriGanesh Jammula; Karsten Hokamp; Darran P O'Connor; Diego Pasini; Gerard Cagney; Adrian P Bracken
Journal:  EMBO J       Date:  2017-05-29       Impact factor: 11.598

2.  RE1-silencing Transcription Factor (REST) Is Required for Nuclear Reprogramming by Inhibiting Transforming Growth Factor β Signaling Pathway.

Authors:  Qing-Ran Kong; Bing-Teng Xie; Heng Zhang; Jing-Yu Li; Tian-Qing Huang; Ren-Yue Wei; Zhong-Hua Liu
Journal:  J Biol Chem       Date:  2016-11-07       Impact factor: 5.157

Review 3.  Protein kinases and associated pathways in pluripotent state and lineage differentiation.

Authors:  Melina Shoni; Kathy O Lui; Demetrios G Vavvas; Michael G Muto; Ross S Berkowitz; Nikolaos Vlahos; Shu-Wing Ng
Journal:  Curr Stem Cell Res Ther       Date:  2014       Impact factor: 3.828

4.  Derivation of stable embryonic stem cell-like, but transcriptionally heterogenous, induced pluripotent stem cells from non-permissive mouse strains.

Authors:  Tiffany A Garbutt; Kranti Konganti; Thomas Konneker; Andrew Hillhouse; Drake Phelps; Alexis Jones; David Aylor; David W Threadgill
Journal:  Mamm Genome       Date:  2020-10-04       Impact factor: 3.224

Review 5.  Extracellular Matrix and Integrins in Embryonic Stem Cell Differentiation.

Authors:  Han Wang; Xie Luo; Jake Leighton
Journal:  Biochem Insights       Date:  2015-09-28

6.  Pluripotency gene expression and growth control in cultures of peripheral blood monocytes during their conversion into programmable cells of monocytic origin (PCMO): evidence for a regulatory role of autocrine activin and TGF-β.

Authors:  Hendrik Ungefroren; Ayman Hyder; Hebke Hinz; Stephanie Groth; Hans Lange; Karim M Fawzy El-Sayed; Sabrina Ehnert; Andreas K Nüssler; Fred Fändrich; Frank Gieseler
Journal:  PLoS One       Date:  2015-02-23       Impact factor: 3.240

7.  Genome-wide microarray expression and genomic alterations by array-CGH analysis in neuroblastoma stem-like cells.

Authors:  Raquel Ordóñez; Gabriel Gallo-Oller; Soledad Martínez-Soto; Sheila Legarra; Noémie Pata-Merci; Justine Guegan; Giselle Danglot; Alain Bernheim; Bárbara Meléndez; Juan A Rey; Javier S Castresana
Journal:  PLoS One       Date:  2014-11-13       Impact factor: 3.240

8.  miR‑146b‑5p promotes the neural conversion of pluripotent stem cells by targeting Smad4.

Authors:  Nianping Zhang; Ying Lyu; Xuebing Pan; Liping Xu; Aiguo Xuan; Xiaosong He; Wandan Huang; Dahong Long
Journal:  Int J Mol Med       Date:  2017-07-11       Impact factor: 4.101

Review 9.  Peripheral Blood Monocytes as Adult Stem Cells: Molecular Characterization and Improvements in Culture Conditions to Enhance Stem Cell Features and Proliferative Potential.

Authors:  Hendrik Ungefroren; Ayman Hyder; Maren Schulze; Karim M Fawzy El-Sayed; Evelin Grage-Griebenow; Andreas K Nussler; Fred Fändrich
Journal:  Stem Cells Int       Date:  2015-12-20       Impact factor: 5.443

10.  Induction of primitive streak and mesendoderm formation in monolayer hESC culture by activation of TGF-β signaling pathway by Activin B.

Authors:  Amer Mahmood; Abdullah Aldahmash
Journal:  Saudi J Biol Sci       Date:  2015-03-10       Impact factor: 4.219
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