Literature DB >> 24298312

Therapeutic transdifferentiation: can we generate cardiac tissue rather than scar after myocardial injury?

Nazish Sayed1, Wing Tak Wong, John P Cooke.   

Abstract

After myocardial injury, the cardiac muscle does not regenerate and heals by forming a scar. This process results in loss of heart function and ultimately heart failure. Recent application of reprogramming technology, where forced expression of master regulators convert scar-forming cells to become cardiovascular cells in vivo, has fueled new hope for the development of therapies targeting heart disease.

Entities:  

Keywords:  cardiomyocytes; cardiovascular diseases; cardiovascular regeneration; transdifferentiation; transflammation

Mesh：

Year:  2013        PMID： 24298312      PMCID： PMC3846075          DOI： 10.14797/mdcj-9-4-210

Source DB:  PubMed          Journal:  Methodist Debakey Cardiovasc J        ISSN： 1947-6108


  27 in total

1.  Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors.

Authors:  Frank Soldner; Dirk Hockemeyer; Caroline Beard; Qing Gao; George W Bell; Elizabeth G Cook; Gunnar Hargus; Alexandra Blak; Oliver Cooper; Maisam Mitalipova; Ole Isacson; Rudolf Jaenisch
Journal:  Cell       Date:  2009-03-06       Impact factor: 41.582

2.  Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution.

Authors:  Nimet Maherali; Rupa Sridharan; Wei Xie; Jochen Utikal; Sarah Eminli; Katrin Arnold; Matthias Stadtfeld; Robin Yachechko; Jason Tchieu; Rudolf Jaenisch; Kathrin Plath; Konrad Hochedlinger
Journal:  Cell Stem Cell       Date:  2007-06-07       Impact factor: 24.633

3.  Cytoplasmic activation of human nuclear genes in stable heterocaryons.

Authors:  H M Blau; C P Chiu; C Webster
Journal:  Cell       Date:  1983-04       Impact factor: 41.582

4.  Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.

Authors:  Kazutoshi Takahashi; Shinya Yamanaka
Journal:  Cell       Date:  2006-08-10       Impact factor: 41.582

5.  Conversion of human fibroblasts to functional endothelial cells by defined factors.

Authors:  Jun Li; Ngan F Huang; Jun Zou; Timothy J Laurent; Jerry C Lee; Janet Okogbaa; John P Cooke; Sheng Ding
Journal:  Arterioscler Thromb Vasc Biol       Date:  2013-03-21       Impact factor: 8.311

6.  Transplantation of undifferentiated murine embryonic stem cells in the heart: teratoma formation and immune response.

Authors:  Jeannette Nussbaum; Elina Minami; Michael A Laflamme; Jitka A I Virag; Carol B Ware; Amanda Masino; Veronica Muskheli; Lil Pabon; Hans Reinecke; Charles E Murry
Journal:  FASEB J       Date:  2007-02-06       Impact factor: 5.191

7.  Induction of pluripotent stem cells from adult human fibroblasts by defined factors.

Authors:  Kazutoshi Takahashi; Koji Tanabe; Mari Ohnuki; Megumi Narita; Tomoko Ichisaka; Kiichiro Tomoda; Shinya Yamanaka
Journal:  Cell       Date:  2007-11-30       Impact factor: 41.582

8.  Generation of germline-competent induced pluripotent stem cells.

Authors:  Keisuke Okita; Tomoko Ichisaka; Shinya Yamanaka
Journal:  Nature       Date:  2007-06-06       Impact factor: 49.962

9.  In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state.

Authors:  Marius Wernig; Alexander Meissner; Ruth Foreman; Tobias Brambrink; Manching Ku; Konrad Hochedlinger; Bradley E Bernstein; Rudolf Jaenisch
Journal:  Nature       Date:  2007-06-06       Impact factor: 49.962

10.  Virus-free induction of pluripotency and subsequent excision of reprogramming factors.

Authors:  Keisuke Kaji; Katherine Norrby; Agnieszka Paca; Maria Mileikovsky; Paria Mohseni; Knut Woltjen
Journal:  Nature       Date:  2009-03-01       Impact factor: 49.962
View more
  4 in total

Review 1.  Translation of Human-Induced Pluripotent Stem Cells: From Clinical Trial in a Dish to Precision Medicine.

Authors:  Nazish Sayed; Chun Liu; Joseph C Wu
Journal:  J Am Coll Cardiol       Date:  2016-05-10       Impact factor: 24.094

2.  A protocol for transdifferentiation of human cardiac fibroblasts into endothelial cells via activation of innate immunity.

Authors:  Chun Liu; Pedro Medina; Dilip Thomas; Ian Y Chen; Karim Sallam; Danish Sayed; Nazish Sayed
Journal:  STAR Protoc       Date:  2021-06-05

Review 3.  Paying the Toll in Nuclear Reprogramming.

Authors:  Chun Liu; Farhan Himmati; Nazish Sayed
Journal:  Front Cell Dev Biol       Date:  2017-08-17

4.  HIF1α Regulates Early Metabolic Changes due to Activation of Innate Immunity in Nuclear Reprogramming.

Authors:  Chun Liu; Hongyue Ruan; Farhan Himmati; Ming-Tao Zhao; Christopher C Chen; Merna Makar; Ian Y Chen; Karim Sallam; Edward S Mocarski; Danish Sayed; Nazish Sayed
Journal:  Stem Cell Reports       Date:  2020-02-11       Impact factor: 7.765
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.