Literature DB >> 27151349

Translation of Human-Induced Pluripotent Stem Cells: From Clinical Trial in a Dish to Precision Medicine.

Nazish Sayed1, Chun Liu2, Joseph C Wu3.   

Abstract

The prospect of changing the plasticity of terminally differentiated cells toward pluripotency has completely altered the outlook for biomedical research. Human-induced pluripotent stem cells (iPSCs) provide a new source of therapeutic cells free from the ethical issues or immune barriers of human embryonic stem cells. iPSCs also confer considerable advantages over conventional methods of studying human diseases. Since its advent, iPSC technology has expanded with 3 major applications: disease modeling, regenerative therapy, and drug discovery. Here we discuss, in a comprehensive manner, the recent advances in iPSC technology in relation to basic, clinical, and population health.
Copyright © 2016 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

Entities:  

Keywords:  drug discovery; human-induced pluripotent stem cells; macromedicine; micromedicine; personalized medicine

Mesh：

Year:  2016        PMID： 27151349      PMCID： PMC5086255          DOI： 10.1016/j.jacc.2016.01.083

Source DB:  PubMed          Journal:  J Am Coll Cardiol        ISSN： 0735-1097            Impact factor:   24.094


  172 in total

1.  Grafted human-induced pluripotent stem-cell-derived neurospheres promote motor functional recovery after spinal cord injury in mice.

Authors:  Satoshi Nori; Yohei Okada; Akimasa Yasuda; Osahiko Tsuji; Yuichiro Takahashi; Yoshiomi Kobayashi; Kanehiro Fujiyoshi; Masato Koike; Yasuo Uchiyama; Eiji Ikeda; Yoshiaki Toyama; Shinya Yamanaka; Masaya Nakamura; Hideyuki Okano
Journal:  Proc Natl Acad Sci U S A       Date:  2011-09-26       Impact factor: 11.205

2.  Identification of a new modulator of the intercalated disc in a zebrafish model of arrhythmogenic cardiomyopathy.

Authors:  Angeliki Asimaki; Sudhir Kapoor; Eva Plovie; Anne Karin Arndt; Edward Adams; ZhenZhen Liu; Cynthia A James; Daniel P Judge; Hugh Calkins; Jared Churko; Joseph C Wu; Calum A MacRae; André G Kléber; Jeffrey E Saffitz
Journal:  Sci Transl Med       Date:  2014-06-11       Impact factor: 17.956

3.  Long-term safety and efficacy of human-induced pluripotent stem cell (iPS) grafts in a preclinical model of retinitis pigmentosa.

Authors:  Yao Li; Yi-Ting Tsai; Chun-Wei Hsu; Deniz Erol; Jin Yang; Wen-Hsuan Wu; Richard J Davis; Dieter Egli; Stephen H Tsang
Journal:  Mol Med       Date:  2012-12-06       Impact factor: 6.354

4.  Human embryonic stem cell-derived cardiomyocytes engraft but do not alter cardiac remodeling after chronic infarction in rats.

Authors:  S Fernandes; A V Naumova; W Z Zhu; M A Laflamme; J Gold; C E Murry
Journal:  J Mol Cell Cardiol       Date:  2010-09-18       Impact factor: 5.000

5.  Production of de novo cardiomyocytes: human pluripotent stem cell differentiation and direct reprogramming.

Authors:  Paul W Burridge; Gordon Keller; Joseph D Gold; Joseph C Wu
Journal:  Cell Stem Cell       Date:  2012-01-06       Impact factor: 24.633

6.  Modeling of Friedreich ataxia-related iron overloading cardiomyopathy using patient-specific-induced pluripotent stem cells.

Authors:  Yee-Ki Lee; Philip Wing-Lok Ho; Revital Schick; Yee-Man Lau; Wing-Hon Lai; Ting Zhou; Yanhua Li; Kwong-Man Ng; Shu-Leung Ho; Miguel Angel Esteban; Ofer Binah; Hung-Fat Tse; Chung-Wah Siu
Journal:  Pflugers Arch       Date:  2013-12-11       Impact factor: 3.657

7.  Genome editing of isogenic human induced pluripotent stem cells recapitulates long QT phenotype for drug testing.

Authors:  Yongming Wang; Ping Liang; Feng Lan; Haodi Wu; Leszek Lisowski; Mingxia Gu; Shijun Hu; Mark A Kay; Fyodor D Urnov; Rami Shinnawi; Joseph D Gold; Lior Gepstein; Joseph C Wu
Journal:  J Am Coll Cardiol       Date:  2014-08-05       Impact factor: 24.094

8.  Human induced pluripotent stem cell-derived cardiomyocytes as an in vitro model for coxsackievirus B3-induced myocarditis and antiviral drug screening platform.

Authors:  Arun Sharma; Caleb Marceau; Ryoko Hamaguchi; Paul W Burridge; Kuppusamy Rajarajan; Jared M Churko; Haodi Wu; Karim I Sallam; Elena Matsa; Anthony C Sturzu; Yonglu Che; Antje Ebert; Sebastian Diecke; Ping Liang; Kristy Red-Horse; Jan E Carette; Sean M Wu; Joseph C Wu
Journal:  Circ Res       Date:  2014-07-11       Impact factor: 17.367

9.  Cardiomyocyte proliferation contributes to heart growth in young humans.

Authors:  Mariya Mollova; Kevin Bersell; Stuart Walsh; Jainy Savla; Lala Tanmoy Das; Shin-Young Park; Leslie E Silberstein; Cristobal G Dos Remedios; Dionne Graham; Steven Colan; Bernhard Kühn
Journal:  Proc Natl Acad Sci U S A       Date:  2013-01-09       Impact factor: 11.205

10.  Cardiomyocytes generated from CPVTD307H patients are arrhythmogenic in response to β-adrenergic stimulation.

Authors:  Atara Novak; Lili Barad; Naama Zeevi-Levin; Revital Shick; Ronit Shtrichman; Avraham Lorber; Joseph Itskovitz-Eldor; Ofer Binah
Journal:  J Cell Mol Med       Date:  2012-03       Impact factor: 5.310
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  92 in total

1.  Patient-Specific Induced Pluripotent Stem Cell-Based Disease Model for Pathogenesis Studies and Clinical Pharmacotherapy.

Authors:  Yingxin Li; Karim Sallam; Peter J Schwartz; Joseph C Wu
Journal:  Circ Arrhythm Electrophysiol       Date:  2017-06

2.  3-Dimensionally Printed, Native-Like Scaffolds for Myocardial Tissue Engineering.

Authors:  Alexa Wnorowski; Joseph C Wu
Journal:  Circ Res       Date:  2017-04-14       Impact factor: 17.367

Review 3.  Progress, obstacles, and limitations in the use of stem cells in organ-on-a-chip models.

Authors:  Alexa Wnorowski; Huaxiao Yang; Joseph C Wu
Journal:  Adv Drug Deliv Rev       Date:  2018-06-06       Impact factor: 15.470

4.  Population-based toxicity screening in human induced pluripotent stem cell-derived cardiomyocytes.

Authors:  Sarah D Burnett; Alexander D Blanchette; Fabian A Grimm; John S House; David M Reif; Fred A Wright; Weihsueh A Chiu; Ivan Rusyn
Journal:  Toxicol Appl Pharmacol       Date:  2019-08-16       Impact factor: 4.219

5.  Relationship Between the Efficacy of Cardiac Cell Therapy and the Inhibition of Differentiation of Human iPSC-Derived Nonmyocyte Cardiac Cells Into Myofibroblast-Like Cells.

Authors:  Ling Gao; Libang Yang; Lu Wang; Zhaohui Geng; Yuhua Wei; Glenn Gourley; Jianyi Zhang
Journal:  Circ Res       Date:  2018-12-07       Impact factor: 17.367

6.  [Leukocyte count of puerperal sows].

Authors:  D Mäde; G Wujanz
Journal:  Berl Munch Tierarztl Wochenschr       Date:  1996-09       Impact factor: 0.328

7.  Contribution of potassium channels to action potential repolarization of human embryonic stem cell-derived cardiomyocytes.

Authors:  Yin Wang; Renjun Zhu; Leslie Tung
Journal:  Br J Pharmacol       Date:  2019-06-26       Impact factor: 8.739

Review 8.  Untangling the Biology of Genetic Cardiomyopathies with Pluripotent Stem Cell Disease Models.

Authors:  Jan W Buikema; Sean M Wu
Journal:  Curr Cardiol Rep       Date:  2017-04       Impact factor: 2.931

9.  The ribosomal prolyl-hydroxylase OGFOD1 decreases during cardiac differentiation and modulates translation and splicing.

Authors:  Andrea Stoehr; Leslie Kennedy; Yanqin Yang; Sajni Patel; Yongshun Lin; Kaari L Linask; Maria Fergusson; Jun Zhu; Marjan Gucek; Jizhong Zou; Elizabeth Murphy
Journal:  JCI Insight       Date:  2019-05-21

Review 10.  Induced pluripotent stem cell technology: a decade of progress.

Authors:  Yanhong Shi; Haruhisa Inoue; Joseph C Wu; Shinya Yamanaka
Journal:  Nat Rev Drug Discov       Date:  2016-12-16       Impact factor: 84.694
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