| Literature DB >> 24298141 |
Abstract
Recent studies of the molecular mechanisms of long-term depression (LTD) suggest a crucial role for the signalling pathways of apoptosis (programmed cell death) in the weakening and elimination of synapses and dendritic spines. With this backdrop, we suggest that LTD can be considered as the electrophysiological aspect of a larger cell biological programme of synapse involution, which uses localized apoptotic mechanisms to sculpt synapses and circuits without causing cell death.Entities:
Keywords: caspase; dendritic spine; local apoptosis; long-term depression; long-term potentiation; spine elimination
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Year: 2013 PMID: 24298141 PMCID: PMC3843871 DOI: 10.1098/rstb.2013.0138
Source DB: PubMed Journal: Philos Trans R Soc Lond B Biol Sci ISSN: 0962-8436 Impact factor: 6.237