Literature DB >> 24298141

Long-term depression: a cell biological view.

Morgan Sheng1, Ali Ertürk.   

Abstract

Recent studies of the molecular mechanisms of long-term depression (LTD) suggest a crucial role for the signalling pathways of apoptosis (programmed cell death) in the weakening and elimination of synapses and dendritic spines. With this backdrop, we suggest that LTD can be considered as the electrophysiological aspect of a larger cell biological programme of synapse involution, which uses localized apoptotic mechanisms to sculpt synapses and circuits without causing cell death.

Entities:  

Keywords:  caspase; dendritic spine; local apoptosis; long-term depression; long-term potentiation; spine elimination

Mesh:

Substances:

Year:  2013        PMID: 24298141      PMCID: PMC3843871          DOI: 10.1098/rstb.2013.0138

Source DB:  PubMed          Journal:  Philos Trans R Soc Lond B Biol Sci        ISSN: 0962-8436            Impact factor:   6.237


  103 in total

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Review 2.  MAPK cascade signalling and synaptic plasticity.

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Review 3.  LTP and LTD: an embarrassment of riches.

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6.  The role of excitatory amino acids and NMDA receptors in traumatic brain injury.

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7.  alpha-Amino-3-hydroxy-5-methylisoxazole-4-propionic acid subtype glutamate receptor (AMPAR) endocytosis is essential for N-methyl-D-aspartate-induced neuronal apoptosis.

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8.  Ca2+ release from Ca2+ stores, particularly from ryanodine-sensitive Ca2+ stores, is required for the induction of LTD in cultured cerebellar Purkinje cells.

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Journal:  J Neurophysiol       Date:  1995-11       Impact factor: 2.714

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Journal:  Brain Res       Date:  1990-05-07       Impact factor: 3.252

Review 10.  Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics.

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Journal:  Br J Cancer       Date:  1972-08       Impact factor: 7.640

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  16 in total

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Journal:  Alcohol       Date:  2017-09-21       Impact factor: 2.405

2.  δ-Catenin Regulates Spine Architecture via Cadherin and PDZ-dependent Interactions.

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3.  Long-term depression induced by endogenous cannabinoids produces neuroprotection via astroglial CB1R after stroke in rodents.

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Journal:  J Cereb Blood Flow Metab       Date:  2018-02-12       Impact factor: 6.200

4.  Caspase-3 is Involved in Aluminum-Induced Impairment of Long-Term Potentiation in Rats Through the Akt/GSK-3β Pathway.

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5.  Synaptic plasticity in health and disease: introduction and overview.

Authors:  T V P Bliss; G L Collingridge; R G M Morris
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2013-12-02       Impact factor: 6.237

6.  Adult-born neurons modify excitatory synaptic transmission to existing neurons.

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Journal:  Elife       Date:  2017-01-30       Impact factor: 8.713

Review 7.  More alive than dead: non-apoptotic roles for caspases in neuronal development, plasticity and disease.

Authors:  Amrita Mukherjee; Darren W Williams
Journal:  Cell Death Differ       Date:  2017-06-23       Impact factor: 15.828

8.  Local apoptotic-like mechanisms underlie complement-mediated synaptic pruning.

Authors:  Balázs A Györffy; Judit Kun; György Török; Éva Bulyáki; Zsolt Borhegyi; Péter Gulyássy; Viktor Kis; Péter Szocsics; András Micsonai; János Matkó; László Drahos; Gábor Juhász; Katalin A Kékesi; József Kardos
Journal:  Proc Natl Acad Sci U S A       Date:  2018-05-29       Impact factor: 11.205

Review 9.  Linking Mitochondria to Synapses: New Insights for Stress-Related Neuropsychiatric Disorders.

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10.  PTEN activation contributes to neuronal and synaptic engulfment by microglia in tauopathy.

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