Literature DB >> 24297212

Bromo- and thiomaleimides as a new class of thiol-mediated fluorescence 'turn-on' reagents.

Judith Youziel1, Ahmed R Akhbar, Qadeer Aziz, Mark E B Smith, Stephen Caddick, Andrew Tinker, James R Baker.   

Abstract

Bromo- and thiomaleimides are shown to serve as highly effective quenchers of a covalently attached fluorophore. Reactions with thiols that lead to removal of the maleimide conjugation, or detachment of the fluorophore from the maleimide, result in 'turn-on' of the fluorescence. These reagents thus offer opportunities in thiol sensing and intracellular reporting.

Entities:  

Mesh：

Substances：

Year:  2014        PMID： 24297212     DOI： 10.1039/c3ob42141d

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  8 in total

1.  Highly selective fluorescence off-on probes for biothiols and imaging in live cells.

Authors:  Di Zhang; Wei Chen; Jianming Kang; Yong Ye; Yufen Zhao; Ming Xian
Journal:  Org Biomol Chem       Date:  2014-09-21       Impact factor: 3.876

2.  Developing Cyclic Opioid Analogues: Fluorescently Labeled Bioconjugates of Biphalin.

Authors:  Azzurra Stefanucci; Marilisa Pia Dimmito; Gabriela Molnar; John M Streicher; Ettore Novellino; Gokhan Zengin; Adriano Mollica
Journal:  ACS Med Chem Lett       Date:  2020-01-08       Impact factor: 4.345

3.  Aminomaleimide fluorophores: a simple functional group with bright, solvent dependent emission.

Authors:  Anne B Mabire; Mathew P Robin; Wen-Dong Quan; Helen Willcock; Vasilios G Stavros; Rachel K O'Reilly
Journal:  Chem Commun (Camb)       Date:  2015-06-14       Impact factor: 6.222

4.  Exploring the Orthogonal Chemoselectivity of 2,4,6-Trichloro-1,3,5-Triazine (TCT) as a Trifunctional Linker With Different Nucleophiles: Rules of the Game.

Authors:  Anamika Sharma; Ayman El-Faham; Beatriz G de la Torre; Fernando Albericio
Journal:  Front Chem       Date:  2018-11-01       Impact factor: 5.221

5.  Clusteroluminescence from Cluster Excitons in Small Heterocyclics Free of Aromatic Rings.

Authors:  Benzhao He; Jing Zhang; Jianyu Zhang; Haoke Zhang; Xiuying Wu; Xu Chen; Konnie H S Kei; Anjun Qin; Herman H Y Sung; Jacky W Y Lam; Ben Zhong Tang
Journal:  Adv Sci (Weinh)       Date:  2021-02-11       Impact factor: 16.806

6.  Structural optimization of reversible dibromomaleimide peptide stapling.

Authors:  Ayanna Lindsey-Crosthwait; Diana Rodriguez-Lema; Martin Walko; Christopher M Pask; Andrew J Wilson
Journal:  Pept Sci (Hoboken)       Date:  2020-03-20

7.  Intramolecular thiomaleimide [2 + 2] photocycloadditions: stereoselective control for disulfide stapling and observation of excited state intermediates by transient absorption spectroscopy.

Authors:  Roshni Malde; Michael A Parkes; Michael Staniforth; Jack M Woolley; Vasilios G Stavros; Vijay Chudasama; Helen H Fielding; James R Baker
Journal:  Chem Sci       Date:  2022-01-28       Impact factor: 9.825

8.  Double quick, double click reversible peptide "stapling".

Authors:  Claire M Grison; George M Burslem; Jennifer A Miles; Ludwig K A Pilsl; David J Yeo; Zeynab Imani; Stuart L Warriner; Michael E Webb; Andrew J Wilson
Journal:  Chem Sci       Date:  2017-05-31       Impact factor: 9.825
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.