Literature DB >> 24292428

First- and second-sphere contributions to Fe(II) site activation by cosubstrate binding in non-heme Fe enzymes.

Kenneth M Light1, John A Hangasky, Michael J Knapp, Edward I Solomon.   

Abstract

Non-heme Fe(II) enzymes exhibit a general mechanistic strategy where binding all cosubstrates opens a coordination site on the Fe(II) for O2 activation. This study shows that strong-donor ligands, steric interactions with the substrate and second-sphere H-bonding to the facial triad carboxylate allow for five-coordinate site formation in this enzyme superfamily.

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Year:  2014        PMID： 24292428      PMCID： PMC3976902          DOI： 10.1039/c3dt53201a

Source DB:  PubMed          Journal:  Dalton Trans        ISSN： 1477-9226            Impact factor:   4.390


  21 in total

Review 1.  Finding intermediates in the O2 activation pathways of non-heme iron oxygenases.

Authors:  E G Kovaleva; M B Neibergall; S Chakrabarty; J D Lipscomb
Journal:  Acc Chem Res       Date:  2007-06-14       Impact factor: 22.384

2.  Role of the nonheme Fe(II) center in the biosynthesis of the plant hormone ethylene.

Authors:  A M Rocklin; D L Tierney; V Kofman; N M Brunhuber; B M Hoffman; R E Christoffersen; N O Reich; J D Lipscomb; L Que
Journal:  Proc Natl Acad Sci U S A       Date:  1999-07-06       Impact factor: 11.205

3.  Structural insight into antibiotic fosfomycin biosynthesis by a mononuclear iron enzyme.

Authors:  Luke J Higgins; Feng Yan; Pinghua Liu; Hung-wen Liu; Catherine L Drennan
Journal:  Nature       Date:  2005-07-13       Impact factor: 49.962

4.  The reaction cycle of isopenicillin N synthase observed by X-ray diffraction.

Authors:  N I Burzlaff; P J Rutledge; I J Clifton; C M Hensgens; M Pickford; R M Adlington; P L Roach; J E Baldwin
Journal:  Nature       Date:  1999-10-14       Impact factor: 49.962

5.  Single turnover chemistry and regulation of O2 activation by the oxygenase component of naphthalene 1,2-dioxygenase.

Authors:  M D Wolfe; J V Parales; D T Gibson; J D Lipscomb
Journal:  J Biol Chem       Date:  2000-10-30       Impact factor: 5.157

6.  Spectroscopic studies of the mononuclear non-heme Fe(II) enzyme FIH: second-sphere contributions to reactivity.

Authors:  Kenneth M Light; John A Hangasky; Michael J Knapp; Edward I Solomon
Journal:  J Am Chem Soc       Date:  2013-06-20       Impact factor: 15.419

7.  Spectroscopic and kinetic studies of PKU-inducing mutants of phenylalanine hydroxylase: Arg158Gln and Glu280Lys.

Authors:  Jyllian N Kemsley; Erik C Wasinger; Supratim Datta; Natasa Mitić; Tara Acharya; Britt Hedman; John P Caradonna; Keith O Hodgson; Edward I Solomon
Journal:  J Am Chem Soc       Date:  2003-05-14       Impact factor: 15.419

8.  2.0A resolution crystal structures of the ternary complexes of human phenylalanine hydroxylase catalytic domain with tetrahydrobiopterin and 3-(2-thienyl)-L-alanine or L-norleucine: substrate specificity and molecular motions related to substrate binding.

Authors:  Ole Andreas Andersen; Anne J Stokka; Torgeir Flatmark; Edward Hough
Journal:  J Mol Biol       Date:  2003-10-31       Impact factor: 5.469

9.  Spectroscopy and kinetics of wild-type and mutant tyrosine hydroxylase: mechanistic insight into O2 activation.

Authors:  Marina S Chow; Bekir E Eser; Samuel A Wilson; Keith O Hodgson; Britt Hedman; Paul F Fitzpatrick; Edward I Solomon
Journal:  J Am Chem Soc       Date:  2009-06-10       Impact factor: 15.419

10.  Substrate-triggered formation and remarkable stability of the C-H bond-cleaving chloroferryl intermediate in the aliphatic halogenase, SyrB2.

Authors:  Megan L Matthews; Courtney M Krest; Eric W Barr; Frédéric H Vaillancourt; Christopher T Walsh; Michael T Green; Carsten Krebs; J Martin Bollinger
Journal:  Biochemistry       Date:  2009-05-26       Impact factor: 3.162
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  4 in total

Review 1.  Mono- and binuclear non-heme iron chemistry from a theoretical perspective.

Authors:  Tibor András Rokob; Jakub Chalupský; Daniel Bím; Prokopis C Andrikopoulos; Martin Srnec; Lubomír Rulíšek
Journal:  J Biol Inorg Chem       Date:  2016-05-26       Impact factor: 3.358

2.  Global stability of an α-ketoglutarate-dependent dioxygenase (TauD) and its related complexes.

Authors:  Kate L Henderson; Mingjie Li; Salette Martinez; Edwin A Lewis; Robert P Hausinger; Joseph P Emerson
Journal:  Biochim Biophys Acta Gen Subj       Date:  2017-02-15       Impact factor: 3.770

3.  O2 Activation by Nonheme FeII α-Ketoglutarate-Dependent Enzyme Variants: Elucidating the Role of the Facial Triad Carboxylate in FIH.

Authors:  Shyam R Iyer; Vanessa D Chaplin; Michael J Knapp; Edward I Solomon
Journal:  J Am Chem Soc       Date:  2018-09-10       Impact factor: 15.419

4.  Protein Flexibility of the α-Ketoglutarate-Dependent Oxygenase Factor-Inhibiting HIF-1: Implications for Substrate Binding, Catalysis, and Regulation.

Authors:  Cristina B Martin; Vanessa D Chaplin; Stephen J Eyles; Michael J Knapp
Journal:  Biochemistry       Date:  2019-09-20       Impact factor: 3.162
  4 in total

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