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Literature DB >> 2429192

The hepatitis delta (delta) virus possesses a circular RNA.

A Kos, R Dijkema, A C Arnberg, P H van der Meide, H Schellekens.

Abstract

Hepatitis delta (delta) virus (HDV), a satellite virus of the hepatitis B virus (HBV), causes a severe form of viral hepatitis in humans. Here we present evidence based on electron microscopy and electrophoretic behaviour that HDV contains a single stranded circular RNA molecule. This is the first animal virus identified with a circular RNA genome. Circular RNAs have only been found in plant viruses. We have obtained a partial complementary DNA clone representing approximately 25% of the total genome of HDV. Analysis of this cDNA revealed similarity to two plant viruses that may explain the origin of the virus.

Entities: Disease Species

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Year: 1986 PMID： 2429192 DOI： 10.1038/323558a0

Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962

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Cited

242 in total

Review 1. RNA editing by adenosine deaminases that act on RNA.

Authors: Brenda L Bass
Journal: Annu Rev Biochem Date: 2001-11-09 Impact factor: 23.643

2. Nucleic acid binding properties of the nucleic acid chaperone domain of hepatitis delta antigen.

Authors: Chun-Chung Wang; Tsung-Cheng Chang; Ching-Wen Lin; Hsiu-Ling Tsui; Page B C Chu; Bo-Shun Chen; Zhi-Shun Huang; Huey-Nan Wu
Journal: Nucleic Acids Res Date: 2003-11-15 Impact factor: 16.971

3. Oligomerization of hepatitis delta antigen is required for both the trans-activating and trans-dominant inhibitory activities of the delta antigen.

Authors: Y P Xia; M M Lai
Journal: J Virol Date: 1992-11 Impact factor: 5.103

4. Mutagenesis analysis of the self-cleavage domain of hepatitis delta virus antigenomic RNA.

Authors: H N Wu; Z S Huang
Journal: Nucleic Acids Res Date: 1992-11-25 Impact factor: 16.971

5. Stable and noncompetitive RNA internal control for routine clinical diagnostic reverse transcription-PCR.

Authors: Kate E Dingle; Derrick Crook; Katie Jeffery
Journal: J Clin Microbiol Date: 2004-03 Impact factor: 5.948

6. The self-cleaving domain from the genomic RNA of hepatitis delta virus: sequence requirements and the effects of denaturant.

Authors: A T Perrotta; M D Been
Journal: Nucleic Acids Res Date: 1990-12-11 Impact factor: 16.971

The hepatitis delta (delta) virus possesses a circular RNA.

Review 1. RNA editing by adenosine deaminases that act on RNA.

2. Nucleic acid binding properties of the nucleic acid chaperone domain of hepatitis delta antigen.

3. Oligomerization of hepatitis delta antigen is required for both the trans-activating and trans-dominant inhibitory activities of the delta antigen.

4. Mutagenesis analysis of the self-cleavage domain of hepatitis delta virus antigenomic RNA.

5. Stable and noncompetitive RNA internal control for routine clinical diagnostic reverse transcription-PCR.

6. The self-cleaving domain from the genomic RNA of hepatitis delta virus: sequence requirements and the effects of denaturant.

7. Determination of the multimerization state of the hepatitis delta virus antigens in vivo.

Review 8. Circular RNAs and hereditary bone diseases.

9. Detecting and characterizing circular RNAs.

10. Local helix content and RNA-binding activity of the N-terminal leucine-repeat region of hepatitis delta antigen.