Literature DB >> 24290062

Small molecule inhibitors of anthrax lethal factor toxin.

John D Williams1, Atiyya R Khan1, Steven C Cardinale1, Michelle M Butler1, Terry L Bowlin1, Norton P Peet2.   

Abstract

This manuscript describes the preparation of new small molecule inhibitors of Bacillus anthracis lethal factor. Our starting point was the symmetrical, bis-quinolinyl compound 1 (NSC 12155). Optimization of one half of this molecule led to new LF inhibitors that were desymmetrized to afford more drug-like compounds.
Copyright © 2013 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Anthrax; Bacillus anthracis; Botulinum neurotoxin A; Desymmetrized; Hybrid compound; Lethal factor; Light chain; Matrix metalloprotease; Quinoline; Zinc metalloprotease

Mesh：

Substances：

Year:  2013        PMID： 24290062      PMCID： PMC3925373          DOI： 10.1016/j.bmc.2013.11.009

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  44 in total

1.  Dominant-negative mutants of a toxin subunit: an approach to therapy of anthrax.

Authors:  B R Sellman; M Mourez; R J Collier
Journal:  Science       Date:  2001-04-27       Impact factor: 47.728

2.  In vitro development of resistance to ofloxacin and doxycycline in Bacillus anthracis Sterne.

Authors:  C H Choe; S S Bouhaouala; I Brook; T B Elliot; G B Knudson
Journal:  Antimicrob Agents Chemother       Date:  2000-06       Impact factor: 5.191

3.  Crystal structure of the anthrax lethal factor.

Authors:  A D Pannifer; T Y Wong; R Schwarzenbacher; M Renatus; C Petosa; J Bienkowska; D B Lacy; R J Collier; S Park; S H Leppla; P Hanna; R C Liddington
Journal:  Nature       Date:  2001-11-08       Impact factor: 49.962

4.  Designing a polyvalent inhibitor of anthrax toxin.

Authors:  M Mourez; R S Kane; J Mogridge; S Metallo; P Deschatelets; B R Sellman; G M Whitesides; R J Collier
Journal:  Nat Biotechnol       Date:  2001-10       Impact factor: 54.908

5.  The discovery of a potent and selective lethal factor inhibitor for adjunct therapy of anthrax infection.

Authors:  Yusheng Xiong; Judyann Wiltsie; Andrea Woods; Jian Guo; James V Pivnichny; Wei Tang; Alka Bansal; Richard T Cummings; Barry R Cunningham; Arthur M Friedlander; Cameron M Douglas; Scott P Salowe; Dennis M Zaller; Edward M Scolnick; Dennis M Schmatz; Kenneth Bartizal; Jeffrey D Hermes; Malcolm MacCoss; Kevin T Chapman
Journal:  Bioorg Med Chem Lett       Date:  2005-12-09       Impact factor: 2.823

6.  Evaluation and binding-mode prediction of thiopyrone-based inhibitors of anthrax lethal factor.

Authors:  Jana A Lewis; John Mongan; J Andrew McCammon; Seth M Cohen
Journal:  ChemMedChem       Date:  2006-07       Impact factor: 3.466

7.  A high-throughput screening approach to anthrax lethal factor inhibition.

Authors:  Sherida L Johnson; Li-Hsing Chen; Maurizio Pellecchia
Journal:  Bioorg Chem       Date:  2007-02-22       Impact factor: 5.275

8.  Anthrax lethal factor inhibition.

Authors:  W L Shoop; Y Xiong; J Wiltsie; A Woods; J Guo; J V Pivnichny; T Felcetto; B F Michael; A Bansal; R T Cummings; B R Cunningham; A M Friedlander; C M Douglas; S B Patel; D Wisniewski; G Scapin; S P Salowe; D M Zaller; K T Chapman; E M Scolnick; D M Schmatz; K Bartizal; M MacCoss; J D Hermes
Journal:  Proc Natl Acad Sci U S A       Date:  2005-05-23       Impact factor: 11.205

9.  Susceptibility to anthrax lethal toxin-induced rat death is controlled by a single chromosome 10 locus that includes rNlrp1.

Authors:  Zachary L Newman; Morton P Printz; Shihui Liu; Devorah Crown; Laura Breen; Sharmina Miller-Randolph; Pamela Flodman; Stephen H Leppla; Mahtab Moayeri
Journal:  PLoS Pathog       Date:  2010-05-20       Impact factor: 6.823

10.  Human anti-anthrax protective antigen neutralizing monoclonal antibodies derived from donors vaccinated with anthrax vaccine adsorbed.

Authors:  Ritsuko Sawada-Hirai; Ivy Jiang; Fei Wang; Shu Man Sun; Rebecca Nedellec; Paul Ruther; Alejandro Alvarez; Diane Millis; Phillip R Morrow; Angray S Kang
Journal:  J Immune Based Ther Vaccines       Date:  2004-05-12
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  1 in total

Review 1.  Inhibitors of the Metalloproteinase Anthrax Lethal Factor.

Authors:  Allison B Goldberg; Benjamin E Turk
Journal:  Curr Top Med Chem       Date:  2016       Impact factor: 3.295
  1 in total

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