| Literature DB >> 16338135 |
Yusheng Xiong1, Judyann Wiltsie, Andrea Woods, Jian Guo, James V Pivnichny, Wei Tang, Alka Bansal, Richard T Cummings, Barry R Cunningham, Arthur M Friedlander, Cameron M Douglas, Scott P Salowe, Dennis M Zaller, Edward M Scolnick, Dennis M Schmatz, Kenneth Bartizal, Jeffrey D Hermes, Malcolm MacCoss, Kevin T Chapman.
Abstract
A potent and selective anthrax LF inhibitor 40, (2R)-2-[(4-fluoro-3-methylphenyl)sulfonylamino]-N-hydroxy-2-(tetrahydro-2H-pyran-4-yl)acetamide, was identified through SAR study of a high throughput screen lead. It has an IC50 of 54 nM in the enzyme assay and an IC50 of 210 nM in the macrophage cytotoxicity assay. Compound 40 is also effective in vivo in several animal model studies.Entities:
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Year: 2005 PMID： 16338135 DOI： 10.1016/j.bmcl.2005.10.088
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823