| Literature DB >> 24286947 |
Helen Vlassara1, Gary E Striker.
Abstract
This review presents insights from studies of advanced glycation end products (AGEs) in humans and mice. Although the emphasis is on the effects of exogenous AGEs and the suppression of specific host defense mechanisms, AGEs are also formed intracellularly, where they may contribute to several normal intracellular functions. It is only when the overall levels of AGEs in the extracellular and the intracellular spaces exceeds the ability of the native antioxidant (and AGE) defenses that they pose a problem.Entities:
Keywords: Advanced glycation endproduct; Diabetes; Insulin resistance; Metabolism
Mesh:
Substances:
Year: 2013 PMID: 24286947 DOI: 10.1016/j.ecl.2013.07.005
Source DB: PubMed Journal: Endocrinol Metab Clin North Am ISSN: 0889-8529 Impact factor: 4.741