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Literature DB >> 24285326

PET radioligands targeting the brain GABAA /benzodiazepine receptor complex.

Abstract

The development of positron emission tomography radioligands for the GABAA /benzodiazepine receptor complex (GABAA receptor) labeled with (11) C and (18) F is examined. The review covers labeling strategies as well as brief biological evaluations of radioligands. In addition, we assess the special considerations that must be taken during a development program for radioligands targeting the GABAA receptor and explore some of the challenges that lie ahead.

Keywords: F-18; GABA; benzodiazepine; radiochemistry; radioligand

Mesh：

Substances：

Year: 2013 PMID： 24285326 DOI： 10.1002/jlcr.3008

Source DB: PubMed Journal: J Labelled Comp Radiopharm ISSN： 0362-4803 Impact factor: 1.921

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Cited

11 in total

Review 1. Fluorine-18 patents (2009-2015). Part 1: novel radiotracers.

Authors: Allen F Brooks; Lindsey R Drake; Megan N Stewart; Brian P Cary; Isaac M Jackson; Dale Mallette; Andrew V Mossine; Peter J H Scott
Journal: Pharm Pat Anal Date: 2015-12-16

2. GABA_A Receptors in the Mongolian Gerbil: a PET Study Using [¹⁸F]Flumazenil to Determine Receptor Binding in Young and Old Animals.

Authors: M Kessler; M Mamach; R Beutelmann; M Lukacevic; S Eilert; P Bascuñana; A Fasel; F M Bengel; J P Bankstahl; T L Ross; G M Klump; G Berding
Journal: Mol Imaging Biol Date: 2020-04 Impact factor: 3.488

Review 3. Classics in Neuroimaging: Development of Positron Emission Tomography Tracers for Imaging the GABAergic Pathway.

Authors: Emily Murrell; Jonathan M Pham; Alexandra R Sowa; Allen F Brooks; Michael R Kilbourn; Peter J H Scott; Neil Vasdev
Journal: ACS Chem Neurosci Date: 2020-06-24 Impact factor: 4.418

Review 4. Selected PET Radioligands for Ion Channel Linked Neuroreceptor Imaging: Focus on GABA, NMDA and nACh Receptors.

Authors: Alina Kassenbrock; Neil Vasdev; Steven H Liang
Journal: Curr Top Med Chem Date: 2016 Impact factor: 3.295

5. Development of Positron Emission Tomography Radiotracers for the GABA Transporter 1.

Authors: Alexandra R Sowa; Allen F Brooks; Xia Shao; Bradford D Henderson; Philip Sherman; Janna Arteaga; Jenelle Stauff; Adam C Lee; Robert A Koeppe; Peter J H Scott; Michael R Kilbourn
Journal: ACS Chem Neurosci Date: 2018-05-24 Impact factor: 4.418

6. Practical Radiosynthesis and Preclinical Neuroimaging of [11C]isradipine, a Calcium Channel Antagonist.

Authors: Benjamin H Rotstein; Steven H Liang; Vasily V Belov; Eli Livni; Dylan B Levine; Ali A Bonab; Mikhail I Papisov; Roy H Perlis; Neil Vasdev
Journal: Molecules Date: 2015-05-26 Impact factor: 4.411

7. Effects of common anesthetic agents on [¹⁸F]flumazenil binding to the GABA_A receptor.

Authors: Mikael Palner; Corinne Beinat; Sam Banister; Francesca Zanderigo; Jun Hyung Park; Bin Shen; Trine Hjoernevik; Jae Ho Jung; Byung Chul Lee; Sang Eun Kim; Lawrence Fung; Frederick T Chin
Journal: EJNMMI Res Date: 2016-11-08 Impact factor: 3.138

Review 8. Drug Development in Alzheimer's Disease: The Contribution of PET and SPECT.

Authors: Lieven D Declercq; Rik Vandenberghe; Koen Van Laere; Alfons Verbruggen; Guy Bormans
Journal: Front Pharmacol Date: 2016-03-31 Impact factor: 5.810

9. Molecular tools for GABA_A receptors: High affinity ligands for β1-containing subtypes.

Authors: Xenia Simeone; David C B Siebert; Konstantina Bampali; Zdravko Varagic; Marco Treven; Sabah Rehman; Jakob Pyszkowski; Raphael Holzinger; Friederike Steudle; Petra Scholze; Marko D Mihovilovic; Michael Schnürch; Margot Ernst
Journal: Sci Rep Date: 2017-07-18 Impact factor: 4.379

Review 10. Emerging PET Radiotracers and Targets for Imaging of Neuroinflammation in Neurodegenerative Diseases: Outlook Beyond TSPO.

Authors: Vidya Narayanaswami; Kenneth Dahl; Vadim Bernard-Gauthier; Lee Josephson; Paul Cumming; Neil Vasdev
Journal: Mol Imaging Date: 2018 Jan-Dec Impact factor: 4.488