Literature DB >> 24284626

Inconsistency in large pharmacogenomic studies.

Benjamin Haibe-Kains1, Nehme El-Hachem2, Nicolai Juul Birkbak3, Andrew C Jin4, Andrew H Beck5, Hugo J W L Aerts6, John Quackenbush7.   

Abstract

Two large-scale pharmacogenomic studies were published recently in this journal. Genomic data are well correlated between studies; however, the measured drug response data are highly discordant. Although the source of inconsistencies remains uncertain, it has potential implications for using these outcome measures to assess gene-drug associations or select potential anticancer drugs on the basis of their reported results.

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Year:  2013        PMID： 24284626      PMCID： PMC4237165          DOI： 10.1038/nature12831

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


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