Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Stem cells: Dual response to Ras mutation.

Literature DB >> 24284623

Stem cells: Dual response to Ras mutation.

S Haihua Chu¹, Scott A Armstrong.

Abstract

Mesh：

Year: 2013 PMID： 24284623 DOI： 10.1038/nature12840

Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962

Keyword Cloud
References

× No keyword cloud information.

11 in total

1. Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair.

Authors: Anne Wilson; Elisa Laurenti; Gabriela Oser; Richard C van der Wath; William Blanco-Bose; Maike Jaworski; Sandra Offner; Cyrille F Dunant; Leonid Eshkind; Ernesto Bockamp; Pietro Lió; H Robson Macdonald; Andreas Trumpp
Journal: Cell Date: 2008-12-12 Impact factor: 41.582

2. Clonal analysis unveils self-renewing lineage-restricted progenitors generated directly from hematopoietic stem cells.

Authors: Ryo Yamamoto; Yohei Morita; Jun Ooehara; Sanae Hamanaka; Masafumi Onodera; Karl Lenhard Rudolph; Hideo Ema; Hiromitsu Nakauchi
Journal: Cell Date: 2013-08-29 Impact factor: 41.582

3. The Wnt/beta-catenin pathway is required for the development of leukemia stem cells in AML.

Authors: Yingzi Wang; Andrei V Krivtsov; Amit U Sinha; Trista E North; Wolfram Goessling; Zhaohui Feng; Leonard I Zon; Scott A Armstrong
Journal: Science Date: 2010-03-26 Impact factor: 47.728

4. Sustained MEK inhibition abrogates myeloproliferative disease in Nf1 mutant mice.

Authors: Tiffany Chang; Kimberly Krisman; Emily Harding Theobald; Jin Xu; Jon Akutagawa; Jennifer O Lauchle; Scott Kogan; Benjamin S Braun; Kevin Shannon
Journal: J Clin Invest Date: 2012-12-10 Impact factor: 14.808

5. Nras(G12D/+) promotes leukemogenesis by aberrantly regulating hematopoietic stem cell functions.

Authors: Jinyong Wang; Guangyao Kong; Yangang Liu; Juan Du; Yuan-I Chang; Sin Ruow Tey; Xinmin Zhang; Erik A Ranheim; Marc K Saba-El-Leil; Sylvain Meloche; Alisa Damnernsawad; Jingfang Zhang; Jing Zhang
Journal: Blood Date: 2013-05-17 Impact factor: 22.113

6. Single-cell profiling identifies aberrant STAT5 activation in myeloid malignancies with specific clinical and biologic correlates.

Authors: Nikesh Kotecha; Nikki J Flores; Jonathan M Irish; Erin F Simonds; Debbie S Sakai; Sophie Archambeault; Ernesto Diaz-Flores; Marc Coram; Kevin M Shannon; Garry P Nolan; Mignon L Loh
Journal: Cancer Cell Date: 2008-10-07 Impact factor: 31.743

Stem cells: Dual response to Ras mutation.

1. Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair.

2. Clonal analysis unveils self-renewing lineage-restricted progenitors generated directly from hematopoietic stem cells.

3. The Wnt/beta-catenin pathway is required for the development of leukemia stem cells in AML.

4. Sustained MEK inhibition abrogates myeloproliferative disease in Nf1 mutant mice.

5. Nras(G12D/+) promotes leukemogenesis by aberrantly regulating hematopoietic stem cell functions.

6. Single-cell profiling identifies aberrant STAT5 activation in myeloid malignancies with specific clinical and biologic correlates.

7. Long-term propagation of distinct hematopoietic differentiation programs in vivo.

8. Dedifferentiation of neurons and astrocytes by oncogenes can induce gliomas in mice.

9. Oncogenic Kras initiates leukemia in hematopoietic stem cells.

10. Oncogenic Nras has bimodal effects on stem cells that sustainably increase competitiveness.