| Literature DB >> 24281889 |
Dongwon Yoo1, Heeyeong Jeong, Seung-Hyun Noh, Jae-Hyun Lee, Jinwoo Cheon.
Abstract
Overcoming resistance: Heat-treated cancer cells possess a protective mechanism for resistance and survival. Resistance-free apoptosis-inducing magnetic nanoparticles (RAINs) successfully promote hyperthermic apoptosis, obstructing cell survival by triggering two functional units of heat generation and the release of geldanamycin (GM) for heat shock protein (Hsp) inhibition under an alternating magnetic field (AMF).Entities:
Keywords: apoptotic hyperthermia; cancer; heat shock proteins; magnetic nanoparticles; thermoresistance
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Year: 2013 PMID: 24281889 DOI: 10.1002/anie.201306557
Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN: 1433-7851 Impact factor: 15.336