| Literature DB >> 24947843 |
Perry T Yin1, Birju P Shah, Ki-Bum Lee.
Abstract
A novel therapy is demonstrated utilizing magnetic nanoparticles for the dual purpose of delivering microRNA and inducing magnetic hyperthermia. In particular, the combination of lethal-7a microRNA (let-7a), which targets a number of the survival pathways that typically limit the effectiveness of hyperthermia, with magnetic hyperthermia greatly enhances apoptosis in brain cancer cells.Entities:
Keywords: drug delivery; hyperthermia; magnetic nanoparticles; microRNA; nanotechnology
Mesh:
Substances:
Year: 2014 PMID: 24947843 PMCID: PMC4206574 DOI: 10.1002/smll.201400963
Source DB: PubMed Journal: Small ISSN: 1613-6810 Impact factor: 13.281