Literature DB >> 24947843

Combined magnetic nanoparticle-based microRNA and hyperthermia therapy to enhance apoptosis in brain cancer cells.

Perry T Yin1, Birju P Shah, Ki-Bum Lee.   

Abstract

A novel therapy is demonstrated utilizing magnetic nanoparticles for the dual purpose of delivering microRNA and inducing magnetic hyperthermia. In particular, the combination of lethal-7a microRNA (let-7a), which targets a number of the survival pathways that typically limit the effectiveness of hyperthermia, with magnetic hyperthermia greatly enhances apoptosis in brain cancer cells.
© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  drug delivery; hyperthermia; magnetic nanoparticles; microRNA; nanotechnology

Mesh:

Substances:

Year:  2014        PMID: 24947843      PMCID: PMC4206574          DOI: 10.1002/smll.201400963

Source DB:  PubMed          Journal:  Small        ISSN: 1613-6810            Impact factor:   13.281


  30 in total

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Journal:  Cell Stress Chaperones       Date:  2005       Impact factor: 3.667

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10.  PI3K/Akt is required for heat shock proteins to protect hypoxia-inducible factor 1alpha from pVHL-independent degradation.

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  37 in total

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Review 5.  Functional and Biomimetic Materials for Engineering of the Three-Dimensional Cell Microenvironment.

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6.  Thermal Therapy Approaches for Treatment of Brain Tumors in Animals and Humans.

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Review 7.  Magnetic nanoparticles and nanocomposites for remote controlled therapies.

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8.  Z-scan method to measure the nonlinear optical behavior of cells for evaluating the cytotoxic effects of chemotherapy and hyperthermia treatments.

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9.  Self-assembled RNA-triple-helix hydrogel scaffold for microRNA modulation in the tumour microenvironment.

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10.  Magnetic nanoparticles in cancer diagnosis, drug delivery and treatment.

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