Literature DB >> 24281312

Can we shorten the lactose tolerance test?

J L Domínguez Jiménez1, A Fernández Suárez2.   

Abstract

BACKGROUND: Lactose malabsorption (LM) is a very common problem with high prevalence in Southern Europe. The lactose tolerance test (LTT) is a basic probe, which is widespread in local hospitals, because it requires non-complex and inexpensive infrastructure. The aims of our study are to determine that a reduction in the duration of LTT does not affect its diagnostic accuracy to detect LM and to calculate the savings that this reduction may represent.
METHODS: A prospective study of consecutive patients who underwent LTT for suspected LM was conducted. We analyzed and compared the clinical results and costs (extraction, analytical measurement, time spent by nursing staff, technicians and patients) of suppressing LTT points at 30 and 120 min.
RESULTS: The study included 201 patients. Pathological LTT was found in 119 cases. Eliminating the measurement of glucose at 120 min did not alter the LTT interpretation in any patient; however, up to 18.4% of patients had a LTT misinterpretation when the 30 min point was suppressed. If the LTT 120 min measurement would have been suppressed, 41,334 euros could have been saved.
CONCLUSIONS: Suppressing the 120 min LTT point does not imply any changes in clinical results and reduces patient's waiting time; it also benefits the health system by saving time, manpower and materials.

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Year:  2013        PMID: 24281312     DOI: 10.1038/ejcn.2013.240

Source DB:  PubMed          Journal:  Eur J Clin Nutr        ISSN: 0954-3007            Impact factor:   4.016


  16 in total

1.  Meta-analysis: the diagnostic accuracy of lactose breath hydrogen or lactose tolerance tests for predicting the North European lactase polymorphism C/T-13910.

Authors:  A Marton; X Xue; A Szilagyi
Journal:  Aliment Pharmacol Ther       Date:  2011-12-28       Impact factor: 8.171

2.  Correlation of intestinal disaccharidase activities with the C/T-13910 variant and age.

Authors:  Nabil-Sabri Enattah; Mikko Kuokkanen; Carol Forsblom; Sirajedin Natah; Aino Oksanen; Irma Jarvela; Leena Peltonen; Erkki Savilahti
Journal:  World J Gastroenterol       Date:  2007-07-07       Impact factor: 5.742

3.  [Pharmacoeconomics: the calculation of efficiency].

Authors:  J A Sacristán; J Soto; J Reviriego; I Galende
Journal:  Med Clin (Barc)       Date:  1994-06-25       Impact factor: 1.725

4.  Prevalence of lactose maldigestion. Influence and interaction of age, race, and sex.

Authors:  D R Rao; H Bello; A P Warren; G E Brown
Journal:  Dig Dis Sci       Date:  1994-07       Impact factor: 3.199

Review 5.  Lactose intolerance: problems in diagnosis and treatment.

Authors:  A D Shaw; G J Davies
Journal:  J Clin Gastroenterol       Date:  1999-04       Impact factor: 3.062

6.  Genetic testing improves the diagnosis of adult type hypolactasia in the Mediterranean population of Sardinia.

Authors:  E Schirru; V Corona; P Usai-Satta; M Scarpa; F Oppia; F Loriga; F Cucca; S De Virgiliis; R Rossino; M Doloretta Macis; R-D Jores; M Congia
Journal:  Eur J Clin Nutr       Date:  2007-02-21       Impact factor: 4.016

7.  Phase I and phase IB clinical trials for the noninvasive evaluation of intestinal lactase with 4-galactosylxylose (gaxilose).

Authors:  Carmen Hermida; Pedro Guerra; Oscar H Martínez-Costa; Valentina Sánchez; José J Sánchez; Jesús Solera; Alfonso Fernández-Mayoralas; Rosa Codoceo; Jesús Frías; Juan J Aragón
Journal:  J Clin Gastroenterol       Date:  2013-07       Impact factor: 3.062

8.  Lactose malabsorption and intolerance: What should be the best clinical management?

Authors:  Paolo Usai-Satta; Mariella Scarpa; Francesco Oppia; Francesco Cabras
Journal:  World J Gastrointest Pharmacol Ther       Date:  2012-06-06

Review 9.  Lactose malabsorption. Optimalization of investigational methods.

Authors:  R J Brummer; M Karibe; R W Stockbrügger
Journal:  Scand J Gastroenterol Suppl       Date:  1993

10.  A comparison of symptoms after the consumption of milk or lactose-hydrolyzed milk by people with self-reported severe lactose intolerance.

Authors:  F L Suarez; D A Savaiano; M D Levitt
Journal:  N Engl J Med       Date:  1995-07-06       Impact factor: 91.245

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  1 in total

1.  Correlation Between Capillary and Venous Blood Glucose in the Lactose Tolerance Test.

Authors:  José Luis Domínguez Jiménez; Antonio Fernández Suárez
Journal:  Dig Dis Sci       Date:  2015-08-30       Impact factor: 3.199

  1 in total

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