Feng-Fan Chiang1, Hwei-Ming Wang1, Yu-Chun Lan2, Min-Hsiu Yang2, Shih-Chien Huang3, Yi-Chia Huang4. 1. Division of Colorectal Surgery, Department of Surgery, Taichung Veterans General Hospital, Taichung, Taiwan. 2. School of Nutrition, Chung Shan Medical University, Taichung, Taiwan; Department of Nutrition, Chung Shan Medical University Hospital, Taichung, Taiwan. 3. Department of Health and Nutrition Biotechnology, Asia University, Taichung, Taiwan. 4. School of Nutrition, Chung Shan Medical University, Taichung, Taiwan; Department of Nutrition, Chung Shan Medical University Hospital, Taichung, Taiwan. Electronic address: ych@csmu.edu.tw.
Abstract
BACKGROUND & AIMS: Increased homocysteine concentration and oxidative stress and decreased antioxidant capacities are thought to affect carcinogenesis. However, the associations of homocysteine, cysteine, pyridoxal 5'-phosphate (PLP) and folate with oxidative stress and antioxidant capacities in patients with colorectal cancer are unclear. The purpose of this study was to determine the associations of homocysteine, cysteine, PLP and folate with oxidative stress indicators and antioxidant capacities, and to further analyze their relationships with respect to risk for colorectal cancer. METHODS: One hundred and sixty-eight subjects with colorectal cancer (cases) and 188 healthy subjects (controls) were recruited. RESULTS: There were no significant associations of homocysteine, cysteine and folate with oxidative stress indicators and antioxidant capacities in cases; however, PLP positively correlated with glutathione S-transferase activities after adjusting for potential confounders in cases. Subjects with higher plasma homocysteine concentration exhibited significantly increased risk of colorectal cancer with or without adjustment for potential confounders. The associations of cysteine, PLP and folate with the risk of colorectal cancer were not observed when potential confounders were adjusted. CONCLUSIONS: Increased homocysteine was strongly associated with the risk of colorectal cancer independently of oxidative stress indicators and antioxidant capacities. However, cysteine, PLP and folate were not found to be related to oxidative stress, antioxidant capacities and the risk of colorectal cancer.
BACKGROUND & AIMS: Increased homocysteine concentration and oxidative stress and decreased antioxidant capacities are thought to affect carcinogenesis. However, the associations of homocysteine, cysteine, pyridoxal 5'-phosphate (PLP) and folate with oxidative stress and antioxidant capacities in patients with colorectal cancer are unclear. The purpose of this study was to determine the associations of homocysteine, cysteine, PLP and folate with oxidative stress indicators and antioxidant capacities, and to further analyze their relationships with respect to risk for colorectal cancer. METHODS: One hundred and sixty-eight subjects with colorectal cancer (cases) and 188 healthy subjects (controls) were recruited. RESULTS: There were no significant associations of homocysteine, cysteine and folate with oxidative stress indicators and antioxidant capacities in cases; however, PLP positively correlated with glutathione S-transferase activities after adjusting for potential confounders in cases. Subjects with higher plasma homocysteine concentration exhibited significantly increased risk of colorectal cancer with or without adjustment for potential confounders. The associations of cysteine, PLP and folate with the risk of colorectal cancer were not observed when potential confounders were adjusted. CONCLUSIONS: Increased homocysteine was strongly associated with the risk of colorectal cancer independently of oxidative stress indicators and antioxidant capacities. However, cysteine, PLP and folate were not found to be related to oxidative stress, antioxidant capacities and the risk of colorectal cancer.
Authors: Eugenia H Miranti; Neal D Freedman; Stephanie J Weinstein; Christian C Abnet; Jacob Selhub; Gwen Murphy; Lena Diaw; Satu Männistö; Philip R Taylor; Demetrius Albanes; Rachael Z Stolzenberg-Solomon Journal: Am J Clin Nutr Date: 2016-08-17 Impact factor: 7.045
Authors: Hanna Karen M Antunes; Marco Túlio De Mello; Valdir de Aquino Lemos; Ruth Ferreira Santos-Galduróz; Luciano Camargo Galdieri; Orlando Francisco Amodeo Bueno; Sergio Tufik; Vânia D'Almeida Journal: Dement Geriatr Cogn Dis Extra Date: 2015-01-21
Authors: Sofia C Nunes; Cristiano Ramos; Filipa Lopes-Coelho; Catarina O Sequeira; Fernanda Silva; Sofia Gouveia-Fernandes; Armanda Rodrigues; António Guimarães; Margarida Silveira; Sofia Abreu; Vítor E Santo; Catarina Brito; Ana Félix; Sofia A Pereira; Jacinta Serpa Journal: Sci Rep Date: 2018-06-22 Impact factor: 4.379