Literature DB >> 25632180

Hyperhomocysteinemia as a potential contributor of colorectal cancer development in inflammatory bowel diseases: a review.

Ammar Hassanzadeh Keshteli1, Vickie E Baracos1, Karen L Madsen1.   

Abstract

Homocysteine is an amino acid generated metabolically by the S-adenosylmethionine-dependent transmethylation pathway. In addition to being a well-known independent risk factor for coronary heart disease, is also a risk factor for cancer. Patients suffering from inflammatory bowel diseases (IBD) including ulcerative colitis and Crohn's disease are at increased risk of developing colorectal cancer in comparison to healthy individuals. Furthermore, the risk of hyperhomocysteinaemia is significantly higher in IBD patients when compared with controls. In the present article, we review the mechanisms in which hyperhomocysteinemia may contribute to increased risk of colorectal cancer in IBD patients.

Entities:  

Keywords:  Colorectal cancer; Hyperhomocysteinemia; Inflammatory bowel disease

Mesh：

Substances：

Year:  2015        PMID： 25632180      PMCID： PMC4306151          DOI： 10.3748/wjg.v21.i4.1081

Source DB:  PubMed          Journal:  World J Gastroenterol        ISSN： 1007-9327            Impact factor:   5.742


  70 in total

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7.  Low vitamin B(6) plasma levels, a risk factor for thrombosis, in inflammatory bowel disease: role of inflammation and correlation with acute phase reactants.

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Journal:  Radiol Oncol       Date:  2010-05-24       Impact factor: 2.991
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  13 in total

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Journal:  Immunogenetics       Date:  2017-05-19       Impact factor: 2.846

2.  The sulfite molecule enhances homocysteine toxicity in SH-SY5Y cells.

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Journal:  Mol Biol Rep       Date:  2019-05-11       Impact factor: 2.316

3.  Effect of Homocysteine on the Differentiation of CD4+ T Cells into Th17 Cells.

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Journal:  Dig Dis Sci       Date:  2018-07-04       Impact factor: 3.199

4.  Associations between Genetic Variants and Blood Biomarkers of One-Carbon Metabolism in Postmenopausal Women from the Women's Health Initiative Observational Study.

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Journal:  J Nutr       Date:  2022-04-01       Impact factor: 4.798

Review 5.  Breast cancer epidemic in the early twenty-first century: evaluation of risk factors, cumulative questionnaires and recommendations for preventive measures.

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Journal:  Tumour Biol       Date:  2016-07-22

Review 6.  Endothelial dysfunction in inflammatory bowel diseases: Pathogenesis, assessment and implications.

Authors:  Dorota Cibor; Renata Domagala-Rodacka; Tomasz Rodacki; Artur Jurczyszyn; Tomasz Mach; Danuta Owczarek
Journal:  World J Gastroenterol       Date:  2016-01-21       Impact factor: 5.742

7.  Nuclear factor erythroid 2-related factor 2 activation mediates hyperhomocysteinemia-associated lipolysis suppression in adipocytes.

Authors:  Xin Li; Yuhong Cheng; Xiuli Zhong; Bing Zhang; Zhiwei Bao; Yi Zhang; Zhigang Wang
Journal:  Exp Biol Med (Maywood)       Date:  2018-07

8.  Type 2 diabetes and the risk of colorectal polyps: A retrospective nationwide population-based study.

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Journal:  Medicine (Baltimore)       Date:  2021-05-14       Impact factor: 1.889

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Authors:  Michał Grabowski; Bogdan Banecki; Leszek Kadziński; Joanna Jakóbkiewicz-Banecka; Magdalena Gabig-Cimińska; Alicja Węgrzyn; Grzegorz Węgrzyn; Zyta Banecka-Majkutewicz
Journal:  Metab Brain Dis       Date:  2016-05-28       Impact factor: 3.584

Review 10.  Colorectal polyp risk is linked to an elevated level of homocysteine.

Authors:  Manchun Sun; Manyi Sun; Li Zhang; Songli Shi
Journal:  Biosci Rep       Date:  2018-04-20       Impact factor: 3.840
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