SCOPE: Equol is produced by the intestinal bacteria from isoflavone daidzein. Studies have reported the health benefits of soy can only present or more pronounced in equol producers. This 6-month randomized controlled trial examined the effect of whole soy (soy flour) and purified daidzein on cardiovascular biomarkers and carotid intima-media thickness (CIMT) in prehypertensive postmenopausal women who were equol producers. METHODS AND RESULTS:Two hundred seventy eligible women were randomized to either one of the three treatments: 40 g soy flour (whole soy group), 40 g low-fat milk powder + 63 mg daidzein (daidzein group), or 40 g low-fat milk powder (placebo group) daily each for 6 months. Fasting venous samples were obtained at baseline and end of trial for testing glucose, lipids, high sensitivity C-reactive protein (hs-CRP), and free fatty acid. Changes in common CIMT were also assessed. Serum LDL-C decreased by 7.95% (95% CI: -15.09∼-0.81%) and 6.32% (95% CI: -13.45∼0.08%), and serum hs-CRP decreased by 0.164 (95% CI: -0.309∼-0.019) and 0.054 (95% CI: -0.199∼0.012) in the whole soy group compared with daidzein and milk placebo groups, respectively. No significant change in CIMT was found. CONCLUSION:Whole soy, but not purified daidzein, had a beneficial effect on reduction of LDL-C and hs-CRP among prehypertensive equol-producing postmenopausal women.
RCT Entities:
SCOPE: Equol is produced by the intestinal bacteria from isoflavone daidzein. Studies have reported the health benefits of soy can only present or more pronounced in equol producers. This 6-month randomized controlled trial examined the effect of whole soy (soy flour) and purified daidzein on cardiovascular biomarkers and carotid intima-media thickness (CIMT) in prehypertensive postmenopausal women who were equol producers. METHODS AND RESULTS: Two hundred seventy eligible women were randomized to either one of the three treatments: 40 g soy flour (whole soy group), 40 g low-fat milk powder + 63 mg daidzein (daidzein group), or 40 g low-fat milk powder (placebo group) daily each for 6 months. Fasting venous samples were obtained at baseline and end of trial for testing glucose, lipids, high sensitivity C-reactive protein (hs-CRP), and free fatty acid. Changes in common CIMT were also assessed. Serum LDL-C decreased by 7.95% (95% CI: -15.09∼-0.81%) and 6.32% (95% CI: -13.45∼0.08%), and serum hs-CRP decreased by 0.164 (95% CI: -0.309∼-0.019) and 0.054 (95% CI: -0.199∼0.012) in the whole soy group compared with daidzein and milk placebo groups, respectively. No significant change in CIMT was found. CONCLUSION: Whole soy, but not purified daidzein, had a beneficial effect on reduction of LDL-C and hs-CRP among prehypertensive equol-producing postmenopausal women.
Authors: Marija Glisic; Natyra Kastrati; Valentina Gonzalez-Jaramillo; Wichor M Bramer; Fariba Ahmadizar; Rajiv Chowdhury; Ah Jan Danser; Anton Jm Roks; Trudy Voortman; Oscar H Franco; Taulant Muka Journal: Adv Nutr Date: 2018-11-01 Impact factor: 8.701
Authors: Tzu-Wen L Cross; Terese M Zidon; Rebecca J Welly; Young-Min Park; Steven L Britton; Lauren G Koch; George E Rottinghaus; Maria R Cattai de Godoy; Jaume Padilla; Kelly S Swanson; Victoria J Vieira-Potter Journal: Sci Rep Date: 2017-08-23 Impact factor: 4.379
Authors: Emily Mt Padhi; Heather J Blewett; Alison M Duncan; Randolph P Guzman; Aileen Hawke; Koushik Seetharaman; Rong Tsao; Thomas Ms Wolever; D Dan Ramdath Journal: J Nutr Date: 2015-10-07 Impact factor: 4.798