Literature DB >> 24272814

Structure of a Neurotoxin that Induces Parkinsonism Symptoms; l-Methyl-4-phenyl-l,2,3,6-tetra-hydropyridine Hydrochloride.

C L Klein1, R F Borne, E D Stevens.   

Abstract

The X-ray crystal structure of the neurotoxin MPTP (l-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) has been elucidated. A comparison of the structural relationship of his agent, which induces Parkinsonism by the selective destruction of nigrostriatal dopamine neurons, to the crystal structure of dopamine is presented.

Entities:  

Year:  1985        PMID： 24272814     DOI： 10.1023/A:1016348308116

Source DB:  PubMed          Journal:  Pharm Res        ISSN： 0724-8741            Impact factor:   4.200


  6 in total

1.  The structure of the catecholamines. II. The crystal structure of dopamine hydrochloride.

Authors:  R Bergin; D Carlström
Journal:  Acta Crystallogr B       Date:  1968-11-15       Impact factor: 2.266

2.  Uptake of MPP(+) by dopamine neurons explains selectivity of parkinsonism-inducing neurotoxin, MPTP.

Authors:  J A Javitch; S H Snyder
Journal:  Eur J Pharmacol       Date:  1984-11-13       Impact factor: 4.432

3.  Studies directed toward testing the "channeling" hypothesis--ribonucleotides----DNA in leukemia L1210 cells.

Authors:  P Chiba; P E Bacon; J G Cory
Journal:  Biochem Biophys Res Commun       Date:  1984-09-17       Impact factor: 3.575

4.  Chronic Parkinsonism secondary to intravenous injection of meperidine analogues.

Authors:  G C Davis; A C Williams; S P Markey; M H Ebert; E D Caine; C M Reichert; I J Kopin
Journal:  Psychiatry Res       Date:  1979-12       Impact factor: 3.222

5.  Pargyline prevents MPTP-induced parkinsonism in primates.

Authors:  J W Langston; I Irwin; E B Langston; L S Forno
Journal:  Science       Date:  1984-09-28       Impact factor: 47.728

6.  Protection against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine by monoamine oxidase inhibitors.

Authors:  R E Heikkila; L Manzino; F S Cabbat; R C Duvoisin
Journal:  Nature       Date:  1984 Oct 4-10       Impact factor: 49.962
  6 in total
  1 in total

1.  Molecular determinants in the bioactivation of the dopaminergic neurotoxin N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

Authors:  S M Efange; R J Boudreau
Journal:  J Comput Aided Mol Des       Date:  1991-10       Impact factor: 3.686
  1 in total

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