Literature DB >> 24272353

Hypoxia and regulation of cancer cell stemness.

Zhong Yun1, Qun Lin.   

Abstract

Spontaneous tumors often contain heterogeneous populations of tumor cells with different tumor-initiating potentials or cancer cell "stemness." Clonal heterogeneity can be traced to specific locations inside a tumor where clones with different metastatic capabilities are identified, suggesting that the tumor microenvironment can exert a significant effect on the evolution of different clonal populations. Hypoxia is a common feature of tumor microenvironments and has the potential to facilitate malignant progression. This chapter provides a synopsis of hypoxia-regulated pathways implicated in the maintenance of cancer stem cells.

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Year:  2014        PMID： 24272353      PMCID： PMC4043215          DOI： 10.1007/978-1-4614-5915-6_2

Source DB:  PubMed          Journal:  Adv Exp Med Biol        ISSN： 0065-2598            Impact factor:   2.622


  105 in total

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Review 2.  Hypoxia--a key regulatory factor in tumour growth.

Authors:  Adrian L Harris
Journal:  Nat Rev Cancer       Date:  2002-01       Impact factor: 60.716

3.  Expression of hypoxia-inducible factor-1alpha: a novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer.

Authors:  D M Aebersold; P Burri; K T Beer; J Laissue; V Djonov; R H Greiner; G L Semenza
Journal:  Cancer Res       Date:  2001-04-01       Impact factor: 12.701

4.  Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein.

Authors:  M Ohh; C W Park; M Ivan; M A Hoffman; T Y Kim; L E Huang; N Pavletich; V Chau; W G Kaelin
Journal:  Nat Cell Biol       Date:  2000-07       Impact factor: 28.824

5.  Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation.

Authors:  P Jaakkola; D R Mole; Y M Tian; M I Wilson; J Gielbert; S J Gaskell; A von Kriegsheim; H F Hebestreit; M Mukherji; C J Schofield; P H Maxwell; C W Pugh; P J Ratcliffe
Journal:  Science       Date:  2001-04-05       Impact factor: 47.728

6.  HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing.

Authors:  M Ivan; K Kondo; H Yang; W Kim; J Valiando; M Ohh; A Salic; J M Asara; W S Lane; W G Kaelin
Journal:  Science       Date:  2001-04-05       Impact factor: 47.728

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Authors:  Zhong Yun; Heather L Maecker; Randall S Johnson; Amato J Giaccia
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Authors:  V Vukovic; H K Haugland; T Nicklee; A J Morrison; D W Hedley
Journal:  Cancer Res       Date:  2001-10-15       Impact factor: 12.701

10.  Hypoxia-inducible factor-1-dependent regulation of the multidrug resistance (MDR1) gene.

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  28 in total

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2.  A microfluidic device to study cancer metastasis under chronic and intermittent hypoxia.

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Journal:  Biomicrofluidics       Date:  2014-10-17       Impact factor: 2.800

Review 3.  Oxidative stress, redox regulation and diseases of cellular differentiation.

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Journal:  Biochim Biophys Acta       Date:  2014-11-15

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6.  Hypoxia Induces the Acquisition of Cancer Stem-like Phenotype Via Upregulation and Activation of Signal Transducer and Activator of Transcription-3 (STAT3) in MDA-MB-231, a Triple Negative Breast Cancer Cell Line.

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7.  Transcriptome analysis reveals high tumor heterogeneity with respect to re-activation of stemness and proliferation programs.

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8.  Peritoneal milky spots serve as a hypoxic niche and favor gastric cancer stem/progenitor cell peritoneal dissemination through hypoxia-inducible factor 1α.

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Journal:  Stem Cells       Date:  2014-12       Impact factor: 6.277

9.  Linearly Patterned Programmed Cell Necrosis Induced by Chronic Hypoxia Plays a Role in Melanoma Angiogenesis.

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10.  Sox9 confers stemness properties in hepatocellular carcinoma through Frizzled-7 mediated Wnt/β-catenin signaling.

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