Literature DB >> 25584114

A microfluidic device to study cancer metastasis under chronic and intermittent hypoxia.

Miguel A Acosta1, Xiao Jiang1, Pin-Kang Huang2, Kyle B Cutler3, Christine S Grant1, Glenn M Walker1, Michael P Gamcsik2.   

Abstract

Metastatic cancer cells must traverse a microenvironment ranging from extremely hypoxic, within the tumor, to highly oxygenated, within the host's vasculature. Tumor hypoxia can be further characterized by regions of both chronic and intermittent hypoxia. We present the design and characterization of a microfluidic device that can simultaneously mimic the oxygenation conditions observed within the tumor and model the cell migration and intravasation processes. This device can generate spatial oxygen gradients of chronic hypoxia and produce dynamically changing hypoxic microenvironments in long-term culture of cancer cells.

Entities:  

Year:  2014        PMID： 25584114      PMCID： PMC4290574          DOI： 10.1063/1.4898788

Source DB:  PubMed          Journal:  Biomicrofluidics        ISSN： 1932-1058            Impact factor:   2.800


  56 in total

1.  Design and development of microbioreactors for long-term cell culture in controlled oxygen microenvironments.

Authors:  Hasan E Abaci; Raghavendra Devendra; Quinton Smith; Sharon Gerecht; German Drazer
Journal:  Biomed Microdevices       Date:  2012-02       Impact factor: 2.838

2.  Microfluidic device for studying cell migration in single or co-existing chemical gradients and electric fields.

Authors:  Jing Li; Ling Zhu; Michael Zhang; Francis Lin
Journal:  Biomicrofluidics       Date:  2012-05-16       Impact factor: 2.800

3.  Matrigel coated polydimethylsiloxane based microfluidic devices for studying metastatic and non-metastatic cancer cell invasion and migration.

Authors:  K C Chaw; M Manimaran; F E H Tay; S Swaminathan
Journal:  Biomed Microdevices       Date:  2007-08       Impact factor: 2.838

4.  Modeling of cancer metastasis and drug resistance via biomimetic nano-cilia and microfluidics.

Authors:  Ching-Te Kuo; Chi-Ling Chiang; Chi-Hao Chang; Hao-Kai Liu; Guan-Syuan Huang; Ruby Yun-Ju Huang; Hsinyu Lee; Chiun-Sheng Huang; Andrew M Wo
Journal:  Biomaterials       Date:  2013-11-22       Impact factor: 12.479

5.  A microsystem for sensing and patterning oxidative microgradients during cell culture.

Authors:  Jaehyun Park; Tushar Bansal; Mikhail Pinelis; Michel M Maharbiz
Journal:  Lab Chip       Date:  2006-03-16       Impact factor: 6.799

6.  Three-dimensional paper-based model for cardiac ischemia.

Authors:  Bobak Mosadegh; Borna E Dabiri; Matthew R Lockett; Ratmir Derda; Patrick Campbell; Kevin Kit Parker; George M Whitesides
Journal:  Adv Healthc Mater       Date:  2014-02-12       Impact factor: 9.933

Review 7.  Relationships between cycling hypoxia, HIF-1, angiogenesis and oxidative stress.

Authors:  Mark W Dewhirst
Journal:  Radiat Res       Date:  2009-12       Impact factor: 2.841

8.  Acute hypoxia enhances spontaneous lymph node metastasis in an orthotopic murine model of human cervical carcinoma.

Authors:  Rob A Cairns; Richard P Hill
Journal:  Cancer Res       Date:  2004-03-15       Impact factor: 12.701

9.  Identification of a stem-like cell population by exposing metastatic breast cancer cell lines to repetitive cycles of hypoxia and reoxygenation.

Authors:  Elizabeth Louie; Sara Nik; Juei-Suei Chen; Marlies Schmidt; Bo Song; Christine Pacson; Xiu Fang Chen; Seonhye Park; Jingfang Ju; Emily I Chen
Journal:  Breast Cancer Res       Date:  2010-11-10       Impact factor: 6.466

10.  Microfluidic endothelium for studying the intravascular adhesion of metastatic breast cancer cells.

Authors:  Jonathan W Song; Stephen P Cavnar; Ann C Walker; Kathryn E Luker; Mudit Gupta; Yi-Chung Tung; Gary D Luker; Shuichi Takayama
Journal:  PLoS One       Date:  2009-06-01       Impact factor: 3.240
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  16 in total

Review 1.  Tumour-on-a-chip: microfluidic models of tumour morphology, growth and microenvironment.

Authors:  Hsieh-Fu Tsai; Alen Trubelja; Amy Q Shen; Gang Bao
Journal:  J R Soc Interface       Date:  2017-06       Impact factor: 4.118

Review 2.  Tumor-on-a-chip for integrating a 3D tumor microenvironment: chemical and mechanical factors.

Authors:  L Wan; C A Neumann; P R LeDuc
Journal:  Lab Chip       Date:  2020-03-03       Impact factor: 6.799

Review 3.  Applications of tumor chip technology.

Authors:  Stephanie J Hachey; Christopher C W Hughes
Journal:  Lab Chip       Date:  2018-09-26       Impact factor: 6.799

4.  Microfluidics: A new tool for modeling cancer-immune interactions.

Authors:  Alexandra Boussommier-Calleja; Ran Li; Michelle B Chen; Siew Cheng Wong; Roger D Kamm
Journal:  Trends Cancer       Date:  2016-01-01

Review 5.  Monitoring and modulation of the tumor microenvironment for enhanced cancer modeling.

Authors:  Tristen Head; Nathaniel C Cady
Journal:  Exp Biol Med (Maywood)       Date:  2022-01-28

6.  Generating linear oxygen gradients across 3D cell cultures with block-layered oxygen controlled chips (BLOCCs).

Authors:  Matthew W Boyce; William C Simke; Rachael M Kenney; Matthew R Lockett
Journal:  Anal Methods       Date:  2019-11-26       Impact factor: 2.896

Review 7.  Obstructive sleep apnea and cancer: Epidemiologic links and theoretical biological constructs.

Authors:  David Gozal; Ramon Farré; F Javier Nieto
Journal:  Sleep Med Rev       Date:  2015-06-03       Impact factor: 11.609

8.  Mixing and delivery of multiple controlled oxygen environments to a single multiwell culture plate.

Authors:  Ming Yao; Tyler Sattler; Zahid N Rabbani; Thomas Pulliam; Glenn Walker; Michael P Gamcsik
Journal:  Am J Physiol Cell Physiol       Date:  2018-09-05       Impact factor: 4.249

9.  Microfluidic Platform for the Long-Term On-Chip Cultivation of Mammalian Cells for Lab-On-A-Chip Applications.

Authors:  Frank Bunge; Sander van den Driesche; Michael J Vellekoop
Journal:  Sensors (Basel)       Date:  2017-07-10       Impact factor: 3.576

10.  A Novel Chip for Cyclic Stretch and Intermittent Hypoxia Cell Exposures Mimicking Obstructive Sleep Apnea.

Authors:  Noelia Campillo; Ignasi Jorba; Laura Schaedel; Blai Casals; David Gozal; Ramon Farré; Isaac Almendros; Daniel Navajas
Journal:  Front Physiol       Date:  2016-07-29       Impact factor: 4.566
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